PMID- 35879706
OWN - NLM
STAT- MEDLINE
DCOM- 20220727
LR  - 20220801
IS  - 1472-6874 (Electronic)
IS  - 1472-6874 (Linking)
VI  - 22
IP  - 1
DP  - 2022 Jul 25
TI  - The relationship between dietary phytochemical index and resting metabolic rate 
      mediated by inflammatory factors in overweight and obese women: a cross-sectional 
      study.
PG  - 313
LID - 10.1186/s12905-022-01894-9 [doi]
LID - 313
AB  - BACKGROUND: Unhealthy dietary patterns are the most important modifiable risk 
      factors for obesity and overweight. This study aimed to examine the relationship 
      between Dietary Phytochemical Index (DPI) and resting metabolic rate (RMR), 
      mediated by inflammatory factors, in overweight and obese women. METHODS: A total 
      of 404 women, aged 18-48 years, were included in the cross-sectional study. DPI 
      was calculated using the 147-item food frequency questionnaire (FFQ). 
      Anthropometric measurements, RMR, and blood biomarkers were assessed using 
      standard protocols. RESULTS: There was marginally significant association between 
      adherence to DPI and RMR status in the crude model (OR = 1.41, 95% CI 0.94-2.11, 
      P = 0.09). After adjusting for potential confounders, a significant association 
      was seen between the DPI and increase RMR.per.kg (OR = 2.77, 95% CI 0.98-7.82, 
      P = 0.05). Our results indicated that plasminogen activator inhibitor-1 (PAI-1), 
      transforming growth factor (TGF-beta), and monocyte chemoattractant protein-1 
      (MCP-1) had a mediatory effect on the association between RMR and DPI (P > 0.05). 
      Indeed, it was shown that, PAI-1, TGF-beta, and MCP-1 destroyed the significance of 
      this association and could be considered as mediating markers. However, no 
      mediating effect was observed for high-sensitivity C reactive protein (hs-CRP). 
      CONCLUSIONS: Adherence to DPI can improve the RMR by reducing levels of 
      inflammatory markers, and may be considered as a treatment for obesity. However, 
      more long-term studies are recommended.
CI  - (c) 2022. The Author(s).
FAU - Mirzababaei, Atieh
AU  - Mirzababaei A
AD  - Department of Community Nutrition, School of Nutritional Sciences and Dietetics, 
      Tehran University of Medical Sciences (TUMS), Tehran, Iran.
FAU - Taheri, Akram
AU  - Taheri A
AD  - Department of Nutrition, Faculty of Medicine, Sciences and Research Branch, 
      Islamic Azad, University, Tehran, Iran.
FAU - Rasaei, Niloufar
AU  - Rasaei N
AD  - Department of Community Nutrition, School of Nutritional Sciences and Dietetics, 
      Tehran University of Medical Sciences (TUMS), Tehran, Iran.
FAU - Mehranfar, Sanaz
AU  - Mehranfar S
AD  - Department of Community Nutrition, School of Nutritional Sciences and Dietetics, 
      Tehran University of Medical Sciences (TUMS), Tehran, Iran.
FAU - Jamili, Shahin
AU  - Jamili S
AD  - Department of Surgery, Shahid Beheshti University of Medical Sciences, Tehran, 
      Iran.
FAU - Clark, Cain C T
AU  - Clark CCT
AD  - Centre for Intelligent Healthcare, Coventry University, Coventry, U.K.
FAU - Mirzaei, Khadijeh
AU  - Mirzaei K
AD  - Department of Community Nutrition, School of Nutritional Sciences and Dietetics, 
      Tehran University of Medical Sciences (TUMS), Tehran, Iran. 
      mirzaei_kh@tums.ac.ir.
AD  - Food Microbiology Research Center, Tehran University of Medical Sciences, Tehran, 
      Iran. mirzaei_kh@tums.ac.ir.
LA  - eng
PT  - Journal Article
DEP - 20220725
PL  - England
TA  - BMC Womens Health
JT  - BMC women's health
JID - 101088690
RN  - 0 (Biomarkers)
RN  - 0 (Phytochemicals)
RN  - 0 (Plasminogen Activator Inhibitor 1)
RN  - 0 (Transforming Growth Factor beta)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - *Basal Metabolism
MH  - Biomarkers
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - Obesity/complications
MH  - *Overweight/complications
MH  - Phytochemicals
MH  - Plasminogen Activator Inhibitor 1
MH  - Transforming Growth Factor beta
MH  - Young Adult
PMC - PMC9317090
OTO - NOTNLM
OT  - Dietary phytochemical index
OT  - Inflammatory marker
OT  - Obesity and overweight
OT  - Resting metabolic rate
COIS- The authors declare that they have no competing interests.
EDAT- 2022/07/26 06:00
MHDA- 2022/07/28 06:00
PMCR- 2022/07/25
CRDT- 2022/07/25 23:45
PHST- 2021/10/20 00:00 [received]
PHST- 2022/07/20 00:00 [accepted]
PHST- 2022/07/25 23:45 [entrez]
PHST- 2022/07/26 06:00 [pubmed]
PHST- 2022/07/28 06:00 [medline]
PHST- 2022/07/25 00:00 [pmc-release]
AID - 10.1186/s12905-022-01894-9 [pii]
AID - 1894 [pii]
AID - 10.1186/s12905-022-01894-9 [doi]
PST - epublish
SO  - BMC Womens Health. 2022 Jul 25;22(1):313. doi: 10.1186/s12905-022-01894-9.