PMID- 35879737
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220729
IS  - 2055-0928 (Electronic)
IS  - 2055-0928 (Linking)
VI  - 8
IP  - 1
DP  - 2022 Jul 25
TI  - Association between serum 25-hydroxyvitamin-D and Triglycerides-Glucose index 
      among Indian adolescents.
PG  - 69
LID - 10.1186/s40795-022-00568-x [doi]
LID - 69
AB  - BACKGROUND: Vitamin D deficiency has been found to associated with numerous 
      skeletal and non-skeletal diseases including Diabetes Mellitus. Insulin 
      Resistance (IR) is considered as one of the primary reasons of Type-2 Diabetes 
      Mellitus (T2DM). The association between vitamin D deficiency and IR has been 
      extensively explore in previous studies, but none of them focused on Indian 
      adolescents, and none of them used the TyG index as IR marker. Hence, this 
      population-based cross-sectional study investigates the relationship between 
      insulin resistance (IR) assessed using the Triglycerides Glucose Index (TyG 
      index) and vitamin D measured by serum 25-hydroxyvitamin-D (25(OH)D). METHODS: 
      For this study, we utilized data from the Comprehensive National Nutrition Survey 
      (CNNS, 2016-18). The study is based on a sample size of 10,167 adolescents aged 
      10-19 years. The TyG index cut-off value of 4.65 was used to classify IR. We 
      examined associations between the TyG index and serum 25(OH)D using multiple 
      linear regression models adjusted for potential confounders. Odds of Insulin 
      Resistance among vitamin D deficient/insufficient adolescents were assessed using 
      multivariable logistic regression. RESULTS: A significant negative association 
      was found between serum 25(OH)D and the TyG index, where a 10% increase in serum 
      25(OH)D was associated with 0.56 (95% CI = -0.67, -0.45) unit decrement in the 
      TyG index. The odds of having IR were 90% higher among vitamin D deficient 
      adolescents (OR: 1.90; 95% CI = 1.62-2.23) compared to adolescents with adequate 
      levels of vitamin D. The association between vitamin D deficiency and IR was 
      independent of sex; in other words, the association between vitamin D and IR was 
      significant in both the sexes. CONCLUSION: Independent of sex, this study found a 
      significant inverse association between vitamin D and insulin resistance in 
      Indian adolescents. The findings of this study highlight the utility of TyG index 
      and the importance of vitamin D in lowering the risk of T2DM in future 
      generations of the country.
CI  - (c) 2022. The Author(s).
FAU - Mustafa, Akif
AU  - Mustafa A
AUID- ORCID: 0000-0002-7917-8922
AD  - International Institute for Population Sciences (IIPS), Mumbai, 400088, India. 
      akifmustafa13@gmail.com.
FAU - Shekhar, Chander
AU  - Shekhar C
AD  - Department of Fertility Studies, International Institute for Population Sciences 
      (IIPS), Mumbai, India.
LA  - eng
PT  - Journal Article
DEP - 20220725
PL  - England
TA  - BMC Nutr
JT  - BMC nutrition
JID - 101672434
PMC - PMC9310494
OTO - NOTNLM
OT  - 25 hydroxyvitamin D
OT  - India
OT  - Insulin resistance
OT  - TyG Index
OT  - Vitamin D
COIS- None of the authors have any conflict of interest to declare.
EDAT- 2022/07/26 06:00
MHDA- 2022/07/26 06:01
PMCR- 2022/07/25
CRDT- 2022/07/25 23:47
PHST- 2022/03/02 00:00 [received]
PHST- 2022/07/19 00:00 [accepted]
PHST- 2022/07/25 23:47 [entrez]
PHST- 2022/07/26 06:00 [pubmed]
PHST- 2022/07/26 06:01 [medline]
PHST- 2022/07/25 00:00 [pmc-release]
AID - 10.1186/s40795-022-00568-x [pii]
AID - 568 [pii]
AID - 10.1186/s40795-022-00568-x [doi]
PST - epublish
SO  - BMC Nutr. 2022 Jul 25;8(1):69. doi: 10.1186/s40795-022-00568-x.