PMID- 35879827
OWN - NLM
STAT- MEDLINE
DCOM- 20220727
LR  - 20220803
IS  - 1473-2300 (Electronic)
IS  - 0300-0605 (Print)
IS  - 0300-0605 (Linking)
VI  - 50
IP  - 7
DP  - 2022 Jul
TI  - Warthin-like mucoepidermoid carcinoma of the parotid gland: a clinicopathological 
      analysis of two cases.
PG  - 3000605221101329
LID - 10.1177/03000605221101329 [doi]
LID - 03000605221101329
AB  - Mucoepidermoid carcinoma (MEC) is the most common malignant tumour of the 
      salivary gland, primarily involving the parotid gland. Here, the cases of two 
      patients, aged 47 and 67 years, respectively, who underwent surgery for 
      pathologically confirmed Warthin-like MEC of the parotid gland between January 
      2019 and December 2019 in Anyang Tumour Hospital, are described. In each case, 
      the tumour consisted of epithelial and lymphoid cell components, covered with two 
      or more layers of epithelium, with visible scattered mucous cells, and lymphoid 
      stroma with a large number of lymphocytes and germinal centres formed. Most 
      importantly, the tumours lacked the well-organized, bilayered oncocytic 
      epithelial structure that is characteristic of Warthin's tumour. Mastermind like 
      transcriptional coactivator 2 (MAML2) gene rearrangements were identified in the 
      tumour cells using break-apart fluorescence in situ hybridization (FISH) probes, 
      confirming the diagnosis of Warthin-like MEC. Post-operatively, patients have 
      remained disease free for 31 and 27 months, respectively. Warthin-like MEC of the 
      parotid gland is rare and is often misdiagnosed as metaplastic Warthin's tumour. 
      Diagnosis depends mainly on the unique clinicopathologic features together with 
      FISH analyses.
FAU - Lei, Ruixue
AU  - Lei R
AUID- ORCID: 0000-0002-1802-6589
AD  - Department of Pathology, Anyang Tumour Hospital, The Affiliated Anyang Tumour 
      Hospital of Henan University of Science and Technology, Anyang, Henan, China.
FAU - Yang, Haijun
AU  - Yang H
AD  - Department of Pathology, Anyang Tumour Hospital, The Affiliated Anyang Tumour 
      Hospital of Henan University of Science and Technology, Anyang, Henan, China.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - J Int Med Res
JT  - The Journal of international medical research
JID - 0346411
RN  - 0 (Transcription Factors)
SB  - IM
MH  - *Adenolymphoma/diagnosis/genetics/surgery
MH  - *Carcinoma, Mucoepidermoid/diagnosis/genetics/surgery
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Parotid Gland/pathology/surgery
MH  - Transcription Factors/genetics
PMC - PMC9340346
OTO - NOTNLM
OT  - MAML2
OT  - Warthin's tumour
OT  - break-apart probes
OT  - fluorescence in situ hybridization
OT  - mucoepidermoid carcinoma
OT  - parotid neoplasm
COIS- Declaration of conflicting interest: The author declares that there is no 
      conflict of interest.
EDAT- 2022/07/27 06:00
MHDA- 2022/07/28 06:00
PMCR- 2022/07/25
CRDT- 2022/07/26 00:13
PHST- 2022/07/26 00:13 [entrez]
PHST- 2022/07/27 06:00 [pubmed]
PHST- 2022/07/28 06:00 [medline]
PHST- 2022/07/25 00:00 [pmc-release]
AID - 10.1177_03000605221101329 [pii]
AID - 10.1177/03000605221101329 [doi]
PST - ppublish
SO  - J Int Med Res. 2022 Jul;50(7):3000605221101329. doi: 10.1177/03000605221101329.