PMID- 35882293
OWN - NLM
STAT- MEDLINE
DCOM- 20220913
LR  - 20220914
IS  - 1096-1186 (Electronic)
IS  - 1043-6618 (Linking)
VI  - 183
DP  - 2022 Sep
TI  - Inulin-type fructans change the gut microbiota and prevent the development of 
      diabetic nephropathy.
PG  - 106367
LID - S1043-6618(22)00312-7 [pii]
LID - 10.1016/j.phrs.2022.106367 [doi]
AB  - Diabetic nephropathy (DN) is the most common cause of end-stage renal disease, 
      and few treatment options that prevent the progressive loss of renal function are 
      available. Studies have shown that dietary fiber intake improves kidney diseases 
      and metabolism-related diseases, most likely through short-chain fatty acids 
      (SCFAs). The present study aimed to examine the protective effects of inulin-type 
      fructans (ITFs) on DN through 16 S rRNA gene sequencing, gas chromatographymass 
      spectrometry (GCMS) analysis and fecal microbiota transplantation (FMT). The 
      results showed that ITFs supplementation protected against kidney damage in db/db 
      mice and regulated the composition of the gut microbiota. Antibiotic treatment 
      and FMT experiments further demonstrated a key role of the gut microbiota in 
      mediating the beneficial effects of ITFs. The ITFs treatment-induced changes in 
      the gut microbiota led to an enrichment of SCFA-producing bacteria, especially 
      the genera Akkermansia and Candidatus Saccharimonas, which increased the fecal 
      and serum acetate concentrations. Subsequently, acetate supplementation improved 
      glomerular damage and renal fibrosis by attenuating mitochondrial dysfunction and 
      reducing toxic glucose metabolite levels. In conclusion, ITFs play a 
      renoprotective role by modulating the gut microbiota and increasing acetate 
      production. Furthermore, acetate mediates renal protection by regulating glucose 
      metabolism, decreasing glycotoxic product levels and improving mitochondrial 
      function.
CI  - Copyright (c) 2022. Published by Elsevier Ltd.
FAU - Luo, Liman
AU  - Luo L
AD  - Department of Geriatric Medicine, Tongji Hospital, Tongji Medical College, 
      Huazhong University of Science and Technology, Wuhan 430030, China; Division of 
      Endocrinology and Department of Internal Medicine, Tongji Hospital, Tongji 
      Medical College, Huazhong University of Science and Technology, Wuhan 430030, 
      China; Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological 
      Disorders, Wuhan 430030, China.
FAU - Luo, Jinlan
AU  - Luo J
AD  - Department of Geriatric Medicine, Tongji Hospital, Tongji Medical College, 
      Huazhong University of Science and Technology, Wuhan 430030, China.
FAU - Cai, Yueting
AU  - Cai Y
AD  - Division of Cardiology and Department of Internal Medicine, Tongji Hospital, 
      Tongji Medical College, Huazhong University of Science and Technology, Wuhan 
      430030, China.
FAU - Fu, Menglu
AU  - Fu M
AD  - Department of Geriatric Medicine, Tongji Hospital, Tongji Medical College, 
      Huazhong University of Science and Technology, Wuhan 430030, China.
FAU - Li, Wenhua
AU  - Li W
AD  - Department of Geriatric Medicine, Tongji Hospital, Tongji Medical College, 
      Huazhong University of Science and Technology, Wuhan 430030, China.
FAU - Shi, Lili
AU  - Shi L
AD  - Department of Geriatric Medicine, Tongji Hospital, Tongji Medical College, 
      Huazhong University of Science and Technology, Wuhan 430030, China.
FAU - Liu, Jingrui
AU  - Liu J
AD  - Division of Cardiology and Department of Internal Medicine, Tongji Hospital, 
      Tongji Medical College, Huazhong University of Science and Technology, Wuhan 
      430030, China.
FAU - Dong, Ruolan
AU  - Dong R
AD  - Institute of Integrated Traditional Chinese and Western Medicine, Tongji 
      Hospital, Tongji Medical College, Huazhong University of Science and Technology, 
      Wuhan 430030, China.
FAU - Xu, Xizhen
AU  - Xu X
AD  - Division of Cardiology and Department of Internal Medicine, Tongji Hospital, 
      Tongji Medical College, Huazhong University of Science and Technology, Wuhan 
      430030, China; Hubei Key Laboratory of Genetics and Molecular Mechanisms of 
      Cardiological Disorders, Wuhan 430030, China.
FAU - Tu, Ling
AU  - Tu L
AD  - Department of Geriatric Medicine, Tongji Hospital, Tongji Medical College, 
      Huazhong University of Science and Technology, Wuhan 430030, China; Hubei Key 
      Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders, Wuhan 
      430030, China. Electronic address: lingtu@tjh.tjmu.edu.cn.
FAU - Yang, Yan
AU  - Yang Y
AD  - Division of Endocrinology and Department of Internal Medicine, Tongji Hospital, 
      Tongji Medical College, Huazhong University of Science and Technology, Wuhan 
      430030, China. Electronic address: 763395987@qq.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220723
PL  - Netherlands
TA  - Pharmacol Res
JT  - Pharmacological research
JID - 8907422
RN  - 0 (Fatty Acids, Volatile)
RN  - 0 (Fructans)
RN  - 9005-80-5 (Inulin)
SB  - IM
MH  - Animals
MH  - Bacteria/metabolism
MH  - *Diabetes Mellitus
MH  - *Diabetic Nephropathies/drug therapy/prevention & control
MH  - Fatty Acids, Volatile/metabolism
MH  - Fructans/pharmacology/therapeutic use
MH  - *Gastrointestinal Microbiome
MH  - Inulin/metabolism/therapeutic use
MH  - Mice
OTO - NOTNLM
OT  - Acetate
OT  - Diabetic nephropathy
OT  - Dietary fiber
OT  - Gut microbiota
OT  - Inulin-type fructans
OT  - Short-chain fatty acids
EDAT- 2022/07/27 06:00
MHDA- 2022/09/14 06:00
CRDT- 2022/07/26 19:13
PHST- 2022/05/27 00:00 [received]
PHST- 2022/07/17 00:00 [revised]
PHST- 2022/07/22 00:00 [accepted]
PHST- 2022/07/27 06:00 [pubmed]
PHST- 2022/09/14 06:00 [medline]
PHST- 2022/07/26 19:13 [entrez]
AID - S1043-6618(22)00312-7 [pii]
AID - 10.1016/j.phrs.2022.106367 [doi]
PST - ppublish
SO  - Pharmacol Res. 2022 Sep;183:106367. doi: 10.1016/j.phrs.2022.106367. Epub 2022 
      Jul 23.