PMID- 35882823
OWN - NLM
STAT- MEDLINE
DCOM- 20221206
LR  - 20221206
IS  - 2210-7711 (Electronic)
VI  - 44
IP  - 6
DP  - 2022 Dec
TI  - Bacillus coagulans TBC169 probiotics for the recovery of intestinal function 
      after gynecological laparoscopic surgery: a randomized, placebo-controlled trial.
PG  - 1287-1295
LID - 10.1007/s11096-022-01451-2 [doi]
AB  - BACKGROUND: Evidence suggests that Bacillus coagulans TBC169 can improve 
      intestinal motility. AIM: To investigate the effectiveness and safety of Bacillus 
      coagulans TBC169 probiotics in promoting the recovery of intestinal function 
      after gynecological laparoscopic surgery. METHOD: Patients who underwent 
      laparoscopic surgeries due to gynecological diseases were randomly assigned to 
      the high-dose, conventional-dose, and the placebo-control groups (1:1:1 ratio). 
      The primary outcome was the time to the first passage of flatus time (FFT). 
      Secondary outcomes were the time to the first defecation (FDT), the time to the 
      first bowel sounds (TFBS), the duration of hospital stay (DHS), and the incidence 
      of postoperative adverse events (AEs). RESULTS: Compared to the placebo-control 
      group, shorter FFT values were observed in the conventional-dose (23.15 h vs. 
      29.10 h, P < 0.05) and high-dose (19.15 h vs. 29.10 h, P < 0.001) groups. Similar 
      trends were observed regarding TFBS in the conventional-dose (18.50 h vs. 
      21.10 h, P < 0.05) and high-dose (15.20 h vs. 21.10 h, P < 0.001) groups. There 
      were no significant differences in FFT and TFBS between the intervention groups. 
      Compared to the placebo-control group, lower incidences of postoperative adverse 
      events were observed in the conventional-dose (12.50% vs. 40.00%, P < 0.05) and 
      the high-dose (5.00% vs. 40.00%, P < 0.001) groups. However, there were no 
      significant differences between these intervention groups. CONCLUSION: Bacillus 
      coagulans TBC169 probiotics can accelerate intestinal function recovery, and 
      reduce postoperative adverse events in patients after gynecological laparoscopic 
      surgery. The study protocol was registered at the Chinese Clinical Trial Registry 
      (ChiCTR2200059518).
CI  - (c) 2022. The Author(s), under exclusive licence to Springer Nature Switzerland AG.
FAU - Li, Zhihong
AU  - Li Z
AD  - Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi 
      Hospital, Third Hospital of Shanxi Medical University, Taiyuan, 030032, China.
AD  - Tongji Hospital, Tongji Medical College, Huazhong University of Science and 
      Technology, Wuhan, 430030, China.
FAU - Guan, Zhaobo
AU  - Guan Z
AD  - School of Pharmacy, Shanxi Medical University, Taiyuan, China.
AD  - Department of Pharmacy, Third Hospital of Shanxi Medical University, Shanxi 
      Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, 99 
      Longcheng Street, Taiyuan, 030032, China.
FAU - Bai, Niuniu
AU  - Bai N
AD  - School of Pharmacy, Shanxi Medical University, Taiyuan, China.
AD  - Department of Pharmacy, Third Hospital of Shanxi Medical University, Shanxi 
      Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, 99 
      Longcheng Street, Taiyuan, 030032, China.
FAU - Yan, Ya
AU  - Yan Y
AD  - School of Pharmacy, Shanxi Medical University, Taiyuan, China.
AD  - Department of Pharmacy, Third Hospital of Shanxi Medical University, Shanxi 
      Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, 99 
      Longcheng Street, Taiyuan, 030032, China.
FAU - Niu, Zhanqin
AU  - Niu Z
AD  - Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi 
      Hospital, Third Hospital of Shanxi Medical University, Taiyuan, 030032, China.
AD  - Tongji Hospital, Tongji Medical College, Huazhong University of Science and 
      Technology, Wuhan, 430030, China.
FAU - Xu, Juan
AU  - Xu J
AD  - Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi 
      Hospital, Third Hospital of Shanxi Medical University, Taiyuan, 030032, China.
AD  - Tongji Hospital, Tongji Medical College, Huazhong University of Science and 
      Technology, Wuhan, 430030, China.
FAU - Gao, Weiqi
AU  - Gao W
AD  - Department of Pharmacy, Third Hospital of Shanxi Medical University, Shanxi 
      Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, 99 
      Longcheng Street, Taiyuan, 030032, China. gaoyang0518@163.com.
FAU - Chen, Weihong
AU  - Chen W
AUID- ORCID: 0000-0002-2972-1069
AD  - School of Pharmacy, Shanxi Medical University, Taiyuan, China. whhchen@126.com.
AD  - Department of Pharmacy, Third Hospital of Shanxi Medical University, Shanxi 
      Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, 99 
      Longcheng Street, Taiyuan, 030032, China. whhchen@126.com.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20220727
PL  - Netherlands
TA  - Int J Clin Pharm
JT  - International journal of clinical pharmacy
JID - 101554912
SB  - IM
EIN - Int J Clin Pharm. 2022 Nov 2;:. PMID: 36323962
MH  - Female
MH  - Humans
MH  - *Bacillus coagulans
MH  - Gynecologic Surgical Procedures/adverse effects
MH  - *Probiotics
MH  - *Laparoscopy/adverse effects
MH  - Recovery of Function
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Bacillus coagulans
OT  - Gynecologic laparoscopy
OT  - Intestinal function
OT  - Probiotics
OT  - Randomized trial
EDAT- 2022/07/27 06:00
MHDA- 2022/12/07 06:00
CRDT- 2022/07/26 23:19
PHST- 2022/05/25 00:00 [received]
PHST- 2022/06/22 00:00 [accepted]
PHST- 2022/07/27 06:00 [pubmed]
PHST- 2022/12/07 06:00 [medline]
PHST- 2022/07/26 23:19 [entrez]
AID - 10.1007/s11096-022-01451-2 [pii]
AID - 10.1007/s11096-022-01451-2 [doi]
PST - ppublish
SO  - Int J Clin Pharm. 2022 Dec;44(6):1287-1295. doi: 10.1007/s11096-022-01451-2. Epub 
      2022 Jul 27.