PMID- 35883303 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20230308 IS - 2076-2615 (Print) IS - 2076-2615 (Electronic) IS - 2076-2615 (Linking) VI - 12 IP - 14 DP - 2022 Jul 8 TI - Impacts of Reducing Protein Content in Milk Replacer on Growth Performance and Health of Young Calves. LID - 10.3390/ani12141756 [doi] LID - 1756 AB - In the present study, a drinking amount of 10 L of milk replacer (MR) was allowed to dairy calves in order to approach the natural drinking behavior. The question is: how much protein is required by calves in order to achieve an intended growth rate? For this reason, sixty-eight pre-weaned Holstein calves were divided into two groups and fed with 10 L/d of MR containing either 22% protein (MR22) or 19% protein (MR19) at an almost comparable energy intake. Effects on performance, metabolic status, and health were compared. Feed intake, growth performance, and health status were monitored during the pre-transition, transition, and postweaning phase (until 157 d of age). Total feed intake, and intake of MR, body weight (BW), and average daily gain (ADG) were not significantly different between MR22 and MR19 during the entire experimental period (p > 0.05). At d 42, calves in MR19 group showed greater serum levels of growth hormone (16.2 vs. 22.2 ng/mL; p = 0.02), insulin-like growth factor 1 (262 vs. 291 ng/mL; p = 0.03), and urea (2.86 vs. 3.04 mmol/L; p < 0.01). The results of the present study suggested that when high amounts of MR are provided, the protein content in MR can be reduced to 19% without any adverse effects on growth performance as well as on health status of dairy calves. FAU - Schubert, Dana Carina AU - Schubert DC AUID- ORCID: 0000-0001-6219-9869 AD - Institute for Animal Nutrition, University of Veterinary Medicine Hannover, Foundation, Bischofsholer Damm 15, D-30173 Hannover, Germany. FAU - Chuppava, Bussarakam AU - Chuppava B AUID- ORCID: 0000-0003-2144-4930 AD - Institute for Animal Nutrition, University of Veterinary Medicine Hannover, Foundation, Bischofsholer Damm 15, D-30173 Hannover, Germany. FAU - Hoffmans, Sandra AU - Hoffmans S AD - Institute for Animal Nutrition, University of Veterinary Medicine Hannover, Foundation, Bischofsholer Damm 15, D-30173 Hannover, Germany. FAU - Pries, Martin AU - Pries M AD - Landwirtschaftskammer Nordrhein-Westfalen, Versuchs- und Bildungszentrum Landwirtschaft, Haus Riswick, D-47533 Kleve, Germany. FAU - Visscher, Christian AU - Visscher C AUID- ORCID: 0000-0003-1497-5709 AD - Institute for Animal Nutrition, University of Veterinary Medicine Hannover, Foundation, Bischofsholer Damm 15, D-30173 Hannover, Germany. FAU - Kamphues, Josef AU - Kamphues J AD - Institute for Animal Nutrition, University of Veterinary Medicine Hannover, Foundation, Bischofsholer Damm 15, D-30173 Hannover, Germany. FAU - Abd El-Wahab, Amr AU - Abd El-Wahab A AUID- ORCID: 0000-0002-2947-6737 AD - Institute for Animal Nutrition, University of Veterinary Medicine Hannover, Foundation, Bischofsholer Damm 15, D-30173 Hannover, Germany. AD - Department of Nutrition and Nutritional Deficiency Diseases, Faculty of Veterinary Medicine, Mansoura University, Mansoura 35516, Egypt. LA - eng GR - LE 824/10-1/Deutsche Forschungsgemeinschaft/ PT - Journal Article DEP - 20220708 PL - Switzerland TA - Animals (Basel) JT - Animals : an open access journal from MDPI JID - 101635614 PMC - PMC9312336 OTO - NOTNLM OT - calf nutrition OT - health OT - milk replacer OT - protein reduction COIS- The authors declare no conflict of interest. EDAT- 2022/07/28 06:00 MHDA- 2022/07/28 06:01 PMCR- 2022/07/08 CRDT- 2022/07/27 01:05 PHST- 2022/05/10 00:00 [received] PHST- 2022/07/01 00:00 [revised] PHST- 2022/07/06 00:00 [accepted] PHST- 2022/07/27 01:05 [entrez] PHST- 2022/07/28 06:00 [pubmed] PHST- 2022/07/28 06:01 [medline] PHST- 2022/07/08 00:00 [pmc-release] AID - ani12141756 [pii] AID - animals-12-01756 [pii] AID - 10.3390/ani12141756 [doi] PST - epublish SO - Animals (Basel). 2022 Jul 8;12(14):1756. doi: 10.3390/ani12141756.