PMID- 35883693
OWN - NLM
STAT- MEDLINE
DCOM- 20220728
LR  - 20221012
IS  - 2073-4409 (Electronic)
IS  - 2073-4409 (Linking)
VI  - 11
IP  - 14
DP  - 2022 Jul 20
TI  - Chaperone-Mediated Autophagy in Neurodegenerative Diseases: Molecular Mechanisms 
      and Pharmacological Opportunities.
LID - 10.3390/cells11142250 [doi]
LID - 2250
AB  - Chaperone-mediated autophagy (CMA) is a protein degradation mechanism through 
      lysosomes. By targeting the KFERQ motif of the substrate, CMA is responsible for 
      the degradation of about 30% of cytosolic proteins, including a series of 
      proteins associated with neurodegenerative diseases (NDs). The fact that 
      decreased activity of CMA is observed in NDs, and ND-associated mutant proteins, 
      including alpha-synuclein and Tau, directly impair CMA activity reveals a 
      possible vicious cycle of CMA impairment and pathogenic protein accumulation in 
      ND development. Given the intrinsic connection between CMA dysfunction and ND, 
      enhancement of CMA has been regarded as a strategy to counteract ND. Indeed, 
      genetic and pharmacological approaches to modulate CMA have been shown to promote 
      the degradation of ND-associated proteins and alleviate ND phenotypes in multiple 
      ND models. This review summarizes the current knowledge on the mechanism of CMA 
      with a focus on its relationship with NDs and discusses the therapeutic potential 
      of CMA modulation for ND.
FAU - Wang, Yi-Ting
AU  - Wang YT
AD  - State Key Laboratory of Quality Research in Chinese Medicine, Institute of 
      Chinese Medical Sciences, University of Macau, Macau SAR 999078, China.
FAU - Lu, Jia-Hong
AU  - Lu JH
AUID- ORCID: 0000-0002-1147-125X
AD  - State Key Laboratory of Quality Research in Chinese Medicine, Institute of 
      Chinese Medical Sciences, University of Macau, Macau SAR 999078, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20220720
PL  - Switzerland
TA  - Cells
JT  - Cells
JID - 101600052
SB  - IM
MH  - Autophagy/genetics
MH  - *Chaperone-Mediated Autophagy
MH  - Humans
MH  - Lysosomes/metabolism
MH  - *Neurodegenerative Diseases/metabolism
PMC - PMC9323300
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - HSC70
OT  - Huntington's disease
OT  - LAMP2A
OT  - Parkinson's disease
OT  - autophagy
OT  - chaperone-mediated autophagy
OT  - neurodegenerative disease
OT  - small molecule
OT  - alpha-synuclein
COIS- The authors declare no conflict of interest.
EDAT- 2022/07/28 06:00
MHDA- 2022/07/29 06:00
PMCR- 2022/07/20
CRDT- 2022/07/27 01:06
PHST- 2022/06/21 00:00 [received]
PHST- 2022/07/12 00:00 [revised]
PHST- 2022/07/15 00:00 [accepted]
PHST- 2022/07/27 01:06 [entrez]
PHST- 2022/07/28 06:00 [pubmed]
PHST- 2022/07/29 06:00 [medline]
PHST- 2022/07/20 00:00 [pmc-release]
AID - cells11142250 [pii]
AID - cells-11-02250 [pii]
AID - 10.3390/cells11142250 [doi]
PST - epublish
SO  - Cells. 2022 Jul 20;11(14):2250. doi: 10.3390/cells11142250.