PMID- 35883835
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220731
IS  - 2076-3921 (Print)
IS  - 2076-3921 (Electronic)
IS  - 2076-3921 (Linking)
VI  - 11
IP  - 7
DP  - 2022 Jul 8
TI  - 7-O-Methylluteolin Suppresses the 2,4-Dinitrochlorobenzene-Induced Nrf2/HO-1 
      Pathway and Atopic Dermatitis-like Lesions.
LID - 10.3390/antiox11071344 [doi]
LID - 1344
AB  - 7-O-methylluteolin (7-ML) is a flavonoid isolated from the aerial parts of 
      Wikstroemia ganpi (W. ganpi). We describe the anti-atopic dermatitis (AD) effects 
      of 7-ML in tert-butyl hydroperoxide (tBHP)-induced HepG2 cells and 
      2,4-dinitrochlorobenzene (DNCB)-induced SKH-1 hairless mice. Results demonstrated 
      that 7-ML dose-dependently inhibited the activation of Nrf2 (nuclear 
      factor-erythroid 2-related factor 2) in tBHP-induced HepG2 cells. 7-ML applied 
      topically to our DNCB-induced mouse model upregulated the antioxidant protein 
      expression (phosphorylated Nrf2 (pNrf2), Nrf2, and heme oxygenase-1 (HO-1)) in 
      skin tissues, improved epidermal thickness, and reduced mast cell infiltration 
      into the skin. In addition, 7-ML reduced the serum levels of immunoglobulin E 
      (IgE) and interleukin-4 (IL-4) and improved skin barrier functions. These results 
      suggest that 7-ML should be considered a novel antioxidant and anti-AD agent.
FAU - Kim, Tae-Young
AU  - Kim TY
AD  - Department of Pharmacy, College of Pharmacy, Pusan National University, Busan 
      46241, Korea.
FAU - Park, No-June
AU  - Park NJ
AD  - Natural Products Research Institute, Korea Institute of Science and Technology, 
      Gangneung 25451, Korea.
FAU - Jo, Beom-Geun
AU  - Jo BG
AD  - Department of Pharmacy, College of Pharmacy, Pusan National University, Busan 
      46241, Korea.
FAU - Paik, Jin-Hyub
AU  - Paik JH
AD  - International Biological Material Research Center, Korea Research Institute of 
      Bioscience and Biotechnology, Daejeon 34141, Korea.
FAU - Choi, Sangho
AU  - Choi S
AD  - International Biological Material Research Center, Korea Research Institute of 
      Bioscience and Biotechnology, Daejeon 34141, Korea.
FAU - Kim, Su-Nam
AU  - Kim SN
AD  - Natural Products Research Institute, Korea Institute of Science and Technology, 
      Gangneung 25451, Korea.
FAU - Yang, Min Hye
AU  - Yang MH
AD  - Department of Pharmacy, College of Pharmacy, Pusan National University, Busan 
      46241, Korea.
LA  - eng
GR  - KGM4582221/Korea Research Institute of Bioscience and Biotechnology (KRIBB) 
      Research Initiative Program/
GR  - NRF-2019M3A9I3080265, NRF-2019M3A9I3080266 and NRF-2022R1A2C1003088/National 
      Research Foundation of Korea/
PT  - Journal Article
DEP - 20220708
PL  - Switzerland
TA  - Antioxidants (Basel)
JT  - Antioxidants (Basel, Switzerland)
JID - 101668981
PMC - PMC9311504
OTO - NOTNLM
OT  - 7-O-methylluteolin
OT  - Wikstroemia ganpi
OT  - anti-inflammation
OT  - antioxidant
OT  - atopic dermatitis
COIS- The authors declare no conflict of interest.
EDAT- 2022/07/28 06:00
MHDA- 2022/07/28 06:01
PMCR- 2022/07/08
CRDT- 2022/07/27 01:07
PHST- 2022/06/13 00:00 [received]
PHST- 2022/07/05 00:00 [revised]
PHST- 2022/07/05 00:00 [accepted]
PHST- 2022/07/27 01:07 [entrez]
PHST- 2022/07/28 06:00 [pubmed]
PHST- 2022/07/28 06:01 [medline]
PHST- 2022/07/08 00:00 [pmc-release]
AID - antiox11071344 [pii]
AID - antioxidants-11-01344 [pii]
AID - 10.3390/antiox11071344 [doi]
PST - epublish
SO  - Antioxidants (Basel). 2022 Jul 8;11(7):1344. doi: 10.3390/antiox11071344.