PMID- 358839
OWN - NLM
STAT- MEDLINE
DCOM- 19781129
LR  - 20171213
IS  - 0002-9513 (Print)
IS  - 0002-9513 (Linking)
VI  - 235
IP  - 3
DP  - 1978 Sep
TI  - Effect of toxigenic Escherichia coli on myoelectric activity of small intestine.
PG  - E311-5
AB  - When exposed to cholera toxin (CT), distal ileal loops of the rabbit small 
      intestine showed an alteration in myoelectric activity. This alteration was 
      defined as the migrating action potential complex (MAPC). The purpose of this 
      study was to determine, using myoelectric recording techniques, the effects of 
      live toxigenic Escherichia coli (TEC) on motility. Live TEC, live nontoxigenic E. 
      coli (NTEC), and culture filtrates of these organisms were studied. Live TEC and 
      its filtrate induced MAPC activity similar to that of CT. Live TEC induced a mean 
      of 3.8 MAPCs/h, significantly greater than induced by live NTEC. TEC filtrate 
      induced a mean of 14.2 MAPCs/h, significantly greater than NTEC filtrate. Heating 
      the TEC filtrate to 100 degrees C before use resulted in a significant decrease 
      of MAPC activity. This experiment demonstrated that live TEC and its culture 
      filtrate altered ileal myoelectric activity. The effect may have been mediated by 
      a heat-labile enterotoxin. This study suggests that alterations in small 
      intestinal motility may be important in the pathogenesis of TEC diarrhea.
FAU - Burns, T W
AU  - Burns TW
FAU - Mathias, J R
AU  - Mathias JR
FAU - Carlson, G M
AU  - Carlson GM
FAU - Martin, J L
AU  - Martin JL
FAU - Shields, R P
AU  - Shields RP
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Am J Physiol
JT  - The American journal of physiology
JID - 0370511
RN  - 0 (Bacterial Toxins)
SB  - IM
MH  - Action Potentials
MH  - Animals
MH  - Bacterial Toxins/*pharmacology
MH  - *Escherichia coli
MH  - *Gastrointestinal Motility
MH  - Intestine, Small/*physiology
MH  - Male
MH  - Rabbits
EDAT- 1978/09/01 00:00
MHDA- 1978/09/01 00:01
CRDT- 1978/09/01 00:00
PHST- 1978/09/01 00:00 [pubmed]
PHST- 1978/09/01 00:01 [medline]
PHST- 1978/09/01 00:00 [entrez]
AID - 10.1152/ajpendo.1978.235.3.E311 [doi]
PST - ppublish
SO  - Am J Physiol. 1978 Sep;235(3):E311-5. doi: 10.1152/ajpendo.1978.235.3.E311.