PMID- 35884341
OWN - NLM
STAT- MEDLINE
DCOM- 20220728
LR  - 20220731
IS  - 2079-6374 (Electronic)
IS  - 2079-6374 (Linking)
VI  - 12
IP  - 7
DP  - 2022 Jul 20
TI  - Development of Nanomaterial-Modified Impedimetric Aptasensor-A Single-Step 
      Strategy for 3,4-Methylenedioxymethylamphetamine Detection.
LID - 10.3390/bios12070538 [doi]
LID - 538
AB  - Developing rapid, sensitive detection methods for 
      3,4-Methylenedioxymethylamphetamine (MDMA) is crucial to reduce its current 
      misuse in the world population. With that aim, we developed an aptamer-modified 
      tin nanoparticle (SnNP)-based nanoarchitecture as an electrochemical sensor in 
      this study. This platform exhibited a high electron transfer rate with enhanced 
      conductivity arising from its large surface area in comparison to the bare 
      electrode. This observation was explained by the 40-fold higher electroactive 
      surface area of SnNPs@Au, which provided a large space for 1.0 muM Apt(MDMA) (0.68 
      +/- 0.36 x 10(12) molecule/cm(2)) immobilization and yielded a significant 
      electrochemical response in the presence of MDMA. Furthermore, the 
      Apt(MDMA)-modified SnNPs@Au sensing platform proved to be a simple yet 
      ultrasensitive analytical device for MDMA detection in spiked biological and 
      water samples. This novel electrochemical aptasensor showed good linearity in the 
      range of 0.01-1.0 nM for MDMA (R(2) = 0.97) with a limit of detection of 0.33 nM 
      and a sensitivity of 0.54 ohm/nM. In addition, the device showed high accuracy 
      and stability along with signal recoveries in the range of 92-96.7% (Relative 
      Standard Deviation, RSD, 1.1-2.18%). In conclusion, the proposed aptasensor 
      developed here is the first to combine SnNPs and aptamers for illicit compound 
      detection, and it offers a reliable platform for recreational drug detection.
FAU - Soni, Shringika
AU  - Soni S
AD  - Amity Institute of Nanotechnology (AINT), Amity University Uttar Pradesh (AUUP), 
      Sector-125, Noida 201313, Uttar Pradesh, India.
FAU - Jain, Utkarsh
AU  - Jain U
AD  - Amity Institute of Nanotechnology (AINT), Amity University Uttar Pradesh (AUUP), 
      Sector-125, Noida 201313, Uttar Pradesh, India.
FAU - Burke, Donald H
AU  - Burke DH
AUID- ORCID: 0000-0001-6513-8391
AD  - Department of Molecular Microbiology and Immunology, Department of Biochemistry, 
      and Bond Life Sciences Center, University of Missouri, Columbia, MO 65211, USA.
FAU - Chauhan, Nidhi
AU  - Chauhan N
AD  - Amity Institute of Nanotechnology (AINT), Amity University Uttar Pradesh (AUUP), 
      Sector-125, Noida 201313, Uttar Pradesh, India.
LA  - eng
GR  - EMR/2016/007564/Science and Engineering Research Board/
GR  - TDP/BDTD/33/2019/Department of Science and Technology/
PT  - Journal Article
DEP - 20220720
PL  - Switzerland
TA  - Biosensors (Basel)
JT  - Biosensors
JID - 101609191
RN  - 0 (Aptamers, Nucleotide)
RN  - 7440-57-5 (Gold)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - *Aptamers, Nucleotide/chemistry
MH  - *Biosensing Techniques/methods
MH  - Electrochemical Techniques/methods
MH  - Gold/chemistry
MH  - Limit of Detection
MH  - *Metal Nanoparticles/chemistry
MH  - *N-Methyl-3,4-methylenedioxyamphetamine
MH  - *Nanostructures
PMC - PMC9312850
OTO - NOTNLM
OT  - 3,4-methylenedioxymethylamphetamine
OT  - aptamer
OT  - electrochemical sensor
OT  - forensic
OT  - recreational drugs
OT  - tin nanoparticles
COIS- The authors have no conflict of interest.
EDAT- 2022/07/28 06:00
MHDA- 2022/07/29 06:00
PMCR- 2022/07/20
CRDT- 2022/07/27 01:09
PHST- 2022/06/19 00:00 [received]
PHST- 2022/07/10 00:00 [revised]
PHST- 2022/07/13 00:00 [accepted]
PHST- 2022/07/27 01:09 [entrez]
PHST- 2022/07/28 06:00 [pubmed]
PHST- 2022/07/29 06:00 [medline]
PHST- 2022/07/20 00:00 [pmc-release]
AID - bios12070538 [pii]
AID - biosensors-12-00538 [pii]
AID - 10.3390/bios12070538 [doi]
PST - epublish
SO  - Biosensors (Basel). 2022 Jul 20;12(7):538. doi: 10.3390/bios12070538.