PMID- 35884811
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220731
IS  - 2227-9059 (Print)
IS  - 2227-9059 (Electronic)
IS  - 2227-9059 (Linking)
VI  - 10
IP  - 7
DP  - 2022 Jun 25
TI  - Non-HLA Antibodies in Kidney Transplantation: Immunity and Genetic Insights.
LID - 10.3390/biomedicines10071506 [doi]
LID - 1506
AB  - The polymorphic human leukocyte antigen (HLA) system has been considered the main 
      target for alloimmunity, but the non-HLA antibodies and autoimmunity have gained 
      importance in kidney transplantation (KT). Apart from the endothelial injury, 
      secondary self-antigen exposure and the presence of polymorphic alloantigens, 
      respectively, auto- and allo- non-HLA antibodies shared common steps in their 
      development, such as: antigen recognition via indirect pathway by recipient 
      antigen presenting cells, autoreactive T cell activation, autoreactive B cell 
      activation, T helper 17 cell differentiation, loss of self-tolerance and epitope 
      spreading phenomena. Both alloimmunity and autoimmunity play a synergic role in 
      the formation of non-HLA antibodies, and the emergence of transcriptomics and 
      genome-wide evaluation techniques has led to important progress in understanding 
      the mechanistic features. Among them, non-HLA mismatches between donors and 
      recipients provide valuable information regarding the role of genetics in non-HLA 
      antibody immunity and development.
FAU - Sorohan, Bogdan Marian
AU  - Sorohan BM
AUID- ORCID: 0000-0003-3574-4635
AD  - Department of General Medicine, Carol Davila University of Medicine and Pharmacy, 
      020021 Bucharest, Romania.
AD  - Center for Uronephrology and Kidney Transplantation, Fundeni Clinical Institute, 
      022328 Bucharest, Romania.
FAU - Baston, Catalin
AU  - Baston C
AD  - Department of General Medicine, Carol Davila University of Medicine and Pharmacy, 
      020021 Bucharest, Romania.
AD  - Center for Uronephrology and Kidney Transplantation, Fundeni Clinical Institute, 
      022328 Bucharest, Romania.
FAU - Tacu, Dorina
AU  - Tacu D
AD  - Center for Uronephrology and Kidney Transplantation, Fundeni Clinical Institute, 
      022328 Bucharest, Romania.
FAU - Bucsa, Cristina
AU  - Bucsa C
AD  - Center for Uronephrology and Kidney Transplantation, Fundeni Clinical Institute, 
      022328 Bucharest, Romania.
FAU - Tincu, Corina
AU  - Tincu C
AD  - Center for Uronephrology and Kidney Transplantation, Fundeni Clinical Institute, 
      022328 Bucharest, Romania.
FAU - Vizireanu, Paula
AU  - Vizireanu P
AD  - Center for Uronephrology and Kidney Transplantation, Fundeni Clinical Institute, 
      022328 Bucharest, Romania.
FAU - Sinescu, Ioanel
AU  - Sinescu I
AD  - Department of General Medicine, Carol Davila University of Medicine and Pharmacy, 
      020021 Bucharest, Romania.
AD  - Center for Uronephrology and Kidney Transplantation, Fundeni Clinical Institute, 
      022328 Bucharest, Romania.
FAU - Constantinescu, Ileana
AU  - Constantinescu I
AD  - Department of General Medicine, Carol Davila University of Medicine and Pharmacy, 
      020021 Bucharest, Romania.
AD  - Department of Immunogenetics, Fundeni Clinical Institute, 022328 Bucharest, 
      Romania.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20220625
PL  - Switzerland
TA  - Biomedicines
JT  - Biomedicines
JID - 101691304
PMC - PMC9312985
OTO - NOTNLM
OT  - AT1R
OT  - ETAR
OT  - antibodies
OT  - antigen
OT  - genetic
OT  - immunity
OT  - kidney transplant
OT  - mismatch
OT  - non-HLA
COIS- The authors declare no conflict of interest.
EDAT- 2022/07/28 06:00
MHDA- 2022/07/28 06:01
PMCR- 2022/06/25
CRDT- 2022/07/27 01:12
PHST- 2022/05/31 00:00 [received]
PHST- 2022/06/22 00:00 [revised]
PHST- 2022/06/24 00:00 [accepted]
PHST- 2022/07/27 01:12 [entrez]
PHST- 2022/07/28 06:00 [pubmed]
PHST- 2022/07/28 06:01 [medline]
PHST- 2022/06/25 00:00 [pmc-release]
AID - biomedicines10071506 [pii]
AID - biomedicines-10-01506 [pii]
AID - 10.3390/biomedicines10071506 [doi]
PST - epublish
SO  - Biomedicines. 2022 Jun 25;10(7):1506. doi: 10.3390/biomedicines10071506.