PMID- 35886009
OWN - NLM
STAT- MEDLINE
DCOM- 20220728
LR  - 20220928
IS  - 2073-4425 (Electronic)
IS  - 2073-4425 (Linking)
VI  - 13
IP  - 7
DP  - 2022 Jul 9
TI  - Unravelling the Distinct Effects of Systolic and Diastolic Blood Pressure Using 
      Mendelian Randomisation.
LID - 10.3390/genes13071226 [doi]
LID - 1226
AB  - A true discrepancy between the effect of systolic blood pressure (SBP) and 
      diastolic blood pressure (DBP) on cardiovascular (CV) outcomes remains unclear. 
      This study performed two-sample Mendelian randomization (MR) using genetic 
      instruments that exclusively predict SBP, DBP or both to dissect the independent 
      effect of SBP and DBP on a range of CV outcomes. Genetic predisposition to higher 
      SBP and DBP was associated with increased risk of coronary artery disease (CAD), 
      myocardial infarction (MI), stroke, heart failure (HF), atrial fibrillation (AF), 
      chronic kidney disease (CKD) and type 2 diabetes mellitus (T2DM). Genetically 
      proxied SBP exclusively was associated with CAD (OR 1.18, 95% CI: 1.03-1.36, per 
      10 mmHg), stroke (1.44[1.28-1.62]), ischemic stroke (1.49[1.30-1.69]), HF 
      (1.41[1.20-1.65]), AF (1.28[1.15-1.43]), and T2DM (1.2[1.13-1.46]). Genetically 
      proxied DBP exclusively was associated with stroke (1.21[1.06-1.37], per 5 mmHg), 
      ischemic stroke (1.24[1.09-1.41]), stroke small-vessel (1.35[1.10-1.65]) and CAD 
      (1.19[1.00-1.41]). Multivariable MR using exclusive SBP and DBP instruments 
      showed the predominant effect of SBP on CAD (1.23[1.05-1.44], per 10 mmHg), 
      stroke (1.39[1.20-1.60]), ischemic stroke (1.44[1.25-1.67]), HF 
      (1.42[1.18-1.71]), AF (1.26[1.10-1.43]) and T2DM (1.31[1.14-1.52]). The 
      discrepancy between effects of SBP and DBP on outcomes warrants further studies 
      on underpinning mechanisms which may be amenable to therapeutic targeting.
FAU - Le, Nhu Ngoc
AU  - Le NN
AD  - Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow 
      G12 8TA, UK.
FAU - Tran, Tran Q B
AU  - Tran TQB
AD  - Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow 
      G12 8TA, UK.
FAU - Lip, Stefanie
AU  - Lip S
AD  - Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow 
      G12 8TA, UK.
FAU - McCallum, Linsay
AU  - McCallum L
AD  - Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow 
      G12 8TA, UK.
FAU - McClure, John
AU  - McClure J
AD  - Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow 
      G12 8TA, UK.
FAU - Dominiczak, Anna F
AU  - Dominiczak AF
AD  - Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow 
      G12 8TA, UK.
FAU - Gill, Dipender
AU  - Gill D
AUID- ORCID: 0000-0001-7312-7078
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Imperial 
      College London, London W2 1PG, UK.
FAU - Padmanabhan, Sandosh
AU  - Padmanabhan S
AUID- ORCID: 0000-0003-3869-5808
AD  - Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow 
      G12 8TA, UK.
LA  - eng
PT  - Journal Article
DEP - 20220709
PL  - Switzerland
TA  - Genes (Basel)
JT  - Genes
JID - 101551097
SB  - IM
MH  - *Atrial Fibrillation/genetics
MH  - Blood Pressure
MH  - *Diabetes Mellitus, Type 2/complications/genetics
MH  - *Heart Failure
MH  - Humans
MH  - *Hypertension/drug therapy
MH  - *Ischemic Stroke
MH  - *Stroke/genetics
PMC - PMC9323763
OTO - NOTNLM
OT  - Mendelian randomization
OT  - blood pressure
OT  - diastolic
OT  - systolic
COIS- D.G. is employed part-time by Novo Nordisk. The other authors report no conflict.
EDAT- 2022/07/28 06:00
MHDA- 2022/07/29 06:00
PMCR- 2022/07/09
CRDT- 2022/07/27 01:17
PHST- 2022/06/21 00:00 [received]
PHST- 2022/07/05 00:00 [revised]
PHST- 2022/07/06 00:00 [accepted]
PHST- 2022/07/27 01:17 [entrez]
PHST- 2022/07/28 06:00 [pubmed]
PHST- 2022/07/29 06:00 [medline]
PHST- 2022/07/09 00:00 [pmc-release]
AID - genes13071226 [pii]
AID - genes-13-01226 [pii]
AID - 10.3390/genes13071226 [doi]
PST - epublish
SO  - Genes (Basel). 2022 Jul 9;13(7):1226. doi: 10.3390/genes13071226.