PMID- 35886029
OWN - NLM
STAT- MEDLINE
DCOM- 20220728
LR  - 20220928
IS  - 2073-4425 (Electronic)
IS  - 2073-4425 (Linking)
VI  - 13
IP  - 7
DP  - 2022 Jul 14
TI  - Genetic Association between Different Metabolic Variants in APOA5 and PLIN1 in 
      Type 2 Diabetes Mellitus among the Western Saudi Population: Case-Control Study.
LID - 10.3390/genes13071246 [doi]
LID - 1246
AB  - Type 2 diabetes mellitus (T2DM) is a multifactorial disease with a high global 
      incidence. Hypertriglyceridemia is a major risk factor for both cardiovascular 
      disease and T2DM. In this study, we determined the allele and genotype 
      frequencies of apolipoprotein A5 (APOA5) single nucleotide polymorphism (SNP) 
      rs662799 and perilipin 1 (PLIN1) SNPs rs894160, rs6496589, and rs1052700 and 
      evaluated their association with T2DM risk in western Saudis. Only rs6496589 was 
      found to be significantly associated with T2DM risk. We determined the risk 
      allele for each SNP based on relative risk, and found that the G allele of 
      rs662799, T allele of rs894160, G allele of r6496589, and T allele of rs1052700 
      correlated with T2DM risk. The effect of each SNP on T2DM risk and five of its 
      clinical phenotypes was explored using multiple logistic regression. We found 
      significant correlations between the C/G and G/G genotypes of rs6496589 and T2DM 
      risk in the unadjusted model, whereas G/G was the only genotype that correlated 
      with the risk of T2DM in the adjusted model. There was no significant correlation 
      between rs662799, rs894160, and rs1052700 genotypes and T2DM risk. In conclusion, 
      we have identified novel risk alleles and genotypes that contribute to genetic 
      risk for T2DM in the western Saudi population.
FAU - Bakhashab, Sherin
AU  - Bakhashab S
AUID- ORCID: 0000-0003-1580-0409
AD  - Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah 
      21589, Saudi Arabia.
AD  - Center of Excellence in Genomic Medicine Research, King Abdulaziz University, 
      Jeddah 21589, Saudi Arabia.
FAU - Alsulami, Tahani
AU  - Alsulami T
AD  - Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah 
      21589, Saudi Arabia.
FAU - Gusti, Amani M T
AU  - Gusti AMT
AUID- ORCID: 0000-0003-4342-6274
AD  - Department of Medical Laboratory, Biochemistry, King Fahad Armed Forces Hospital, 
      Jeddah 21159, Saudi Arabia.
FAU - Harakeh, Steve
AU  - Harakeh S
AUID- ORCID: 0000-0001-7512-8787
AD  - King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi 
      Arabia.
AD  - Yousef Abdul Lateef Jameel Chair of Prophetic Medicine Application, Faculty of 
      Medicine, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
FAU - Al-Raddadi, Rajaa
AU  - Al-Raddadi R
AUID- ORCID: 0000-0002-8921-9628
AD  - Department of Community Medicine, Faculty of Medicine, King Abdulaziz University, 
      Jeddah 21589, Saudi Arabia.
FAU - Alwazani, Wissam A
AU  - Alwazani WA
AD  - Department of Biological Sciences, Faculty of Science, University of Jordan, 
      Amman 11953, Jordan.
FAU - Alshaibi, Huda F
AU  - Alshaibi HF
AUID- ORCID: 0000-0003-3739-8844
AD  - Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah 
      21589, Saudi Arabia.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220714
PL  - Switzerland
TA  - Genes (Basel)
JT  - Genes
JID - 101551097
RN  - 0 (APOA5 protein, human)
RN  - 0 (Apolipoprotein A-V)
RN  - 0 (PLIN1 protein, human)
RN  - 0 (Perilipin-1)
SB  - IM
MH  - Apolipoprotein A-V/genetics
MH  - Case-Control Studies
MH  - *Diabetes Mellitus, Type 2/epidemiology/genetics
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Perilipin-1/genetics
MH  - Saudi Arabia/epidemiology
PMC - PMC9316528
OTO - NOTNLM
OT  - apolipoprotein A5
OT  - perilipin 1
OT  - single nucleotide polymorphism
OT  - type 2 diabetes mellitus
COIS- The authors declare no conflict of interest.
EDAT- 2022/07/28 06:00
MHDA- 2022/07/29 06:00
PMCR- 2022/07/14
CRDT- 2022/07/27 01:17
PHST- 2022/05/15 00:00 [received]
PHST- 2022/07/03 00:00 [revised]
PHST- 2022/07/13 00:00 [accepted]
PHST- 2022/07/27 01:17 [entrez]
PHST- 2022/07/28 06:00 [pubmed]
PHST- 2022/07/29 06:00 [medline]
PHST- 2022/07/14 00:00 [pmc-release]
AID - genes13071246 [pii]
AID - genes-13-01246 [pii]
AID - 10.3390/genes13071246 [doi]
PST - epublish
SO  - Genes (Basel). 2022 Jul 14;13(7):1246. doi: 10.3390/genes13071246.