PMID- 35886975
OWN - NLM
STAT- MEDLINE
DCOM- 20220728
LR  - 20220731
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 23
IP  - 14
DP  - 2022 Jul 10
TI  - Differential Cellular Balance of Olfactory and Vomeronasal Epithelia in a 
      Transgenic BACHD Rat Model of Huntington's Disease.
LID - 10.3390/ijms23147625 [doi]
LID - 7625
AB  - Background. For neurodegenerative diseases such as Huntington's disease (HD), 
      early diagnosis is essential to treat patients and delay symptoms. Impaired 
      olfaction, as observed as an early symptom in Parkinson s disease, may also 
      constitute a key symptom in HD. However, there are few reports on olfactory 
      deficits in HD. Therefore, we aimed to investigate, in a transgenic rat model of 
      HD: (1) whether general olfactory impairment exists and (2) whether there are 
      disease-specific dynamics of olfactory dysfunction when the vomeronasal (VNE) and 
      main olfactory epithelium (MOE) are compared. Methods. We used male rats of 
      transgenic line 22 (TG22) of the bacterial artificial chromosome Huntington 
      disease model (BACHD), aged 3 days or 6 months. Cell proliferation, apoptosis and 
      macrophage activity were examined with immunohistochemistry in the VNE and MOE. 
      Results. No differences were observed in cellular parameters in the VNE between 
      the groups. However, the MOE of the 6-month-old HD animals showed a significantly 
      increased number of mature olfactory receptor neurons. Other cellular parameters 
      were not affected. Conclusions. The results obtained in the TG22 line suggest a 
      relative stability in the VNE, whereas the MOE seems at least temporarily 
      affected.
FAU - Krysewski, Lina-Marielle
AU  - Krysewski LM
AUID- ORCID: 0000-0003-2363-2302
AD  - Department of Anatomy, Rostock University Medical Centre, 18057 Rostock, Germany.
FAU - Power Guerra, Nicole
AU  - Power Guerra N
AD  - Department of Anatomy, Rostock University Medical Centre, 18057 Rostock, Germany.
AD  - Rudolf-Zenker-Institute for Experimental Surgery, Rostock University Medical 
      Centre, 18057 Rostock, Germany.
AD  - Smell and Taste Clinic, Department of Otorhinolaryngology, TU Dresden, 01034 
      Dresden, Germany.
FAU - Glatzel, Annika
AU  - Glatzel A
AD  - Department of Anatomy, Rostock University Medical Centre, 18057 Rostock, Germany.
FAU - Holzmann, Carsten
AU  - Holzmann C
AUID- ORCID: 0000-0001-7977-9093
AD  - Institute of Medical Genetics, Rostock University Medical Centre, 18057 Rostock, 
      Germany.
FAU - Antipova, Veronica
AU  - Antipova V
AUID- ORCID: 0000-0002-7631-9080
AD  - Department of Anatomy, Rostock University Medical Centre, 18057 Rostock, Germany.
AD  - Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, 
      Macroscopic and Clinical Anatomy, Medical University of Graz, 8010 Graz, Austria.
FAU - Schmitt, Oliver
AU  - Schmitt O
AD  - Department of Anatomy, Rostock University Medical Centre, 18057 Rostock, Germany.
AD  - Department of Anatomy, Medical School Hamburg, University of Applied Sciences and 
      Medical University, 20457 Hamburg, Germany.
FAU - Yu-Taeger, Libo
AU  - Yu-Taeger L
AD  - Department of Human Genetics, Ruhr University Bochum, 44780 Bochum, Germany.
FAU - Nguyen, Huu Phuc
AU  - Nguyen HP
AUID- ORCID: 0000-0001-6139-788X
AD  - Department of Human Genetics, Ruhr University Bochum, 44780 Bochum, Germany.
FAU - Wree, Andreas
AU  - Wree A
AD  - Department of Anatomy, Rostock University Medical Centre, 18057 Rostock, Germany.
FAU - Witt, Martin
AU  - Witt M
AUID- ORCID: 0000-0002-4538-877X
AD  - Department of Anatomy, Rostock University Medical Centre, 18057 Rostock, Germany.
LA  - eng
GR  - 889046 and 889052/FORUN (internal University grant)/
PT  - Journal Article
DEP - 20220710
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
SB  - IM
MH  - Animals
MH  - Chromosomes, Artificial, Bacterial
MH  - Disease Models, Animal
MH  - *Huntington Disease/metabolism
MH  - Male
MH  - *Olfaction Disorders/metabolism
MH  - Olfactory Mucosa/metabolism
MH  - *Olfactory Receptor Neurons/metabolism
MH  - Rats
MH  - Rats, Transgenic
PMC - PMC9316117
OTO - NOTNLM
OT  - Huntington's disease
OT  - buried pellet test
OT  - main olfactory epithelium
OT  - olfaction
OT  - transgenic rat model
OT  - vomeronasal organ
COIS- The authors declare no conflict of interest.
EDAT- 2022/07/28 06:00
MHDA- 2022/07/29 06:00
PMCR- 2022/07/10
CRDT- 2022/07/27 01:22
PHST- 2022/05/24 00:00 [received]
PHST- 2022/07/05 00:00 [revised]
PHST- 2022/07/05 00:00 [accepted]
PHST- 2022/07/27 01:22 [entrez]
PHST- 2022/07/28 06:00 [pubmed]
PHST- 2022/07/29 06:00 [medline]
PHST- 2022/07/10 00:00 [pmc-release]
AID - ijms23147625 [pii]
AID - ijms-23-07625 [pii]
AID - 10.3390/ijms23147625 [doi]
PST - epublish
SO  - Int J Mol Sci. 2022 Jul 10;23(14):7625. doi: 10.3390/ijms23147625.