PMID- 35887078
OWN - NLM
STAT- MEDLINE
DCOM- 20220728
LR  - 20220731
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 23
IP  - 14
DP  - 2022 Jul 13
TI  - Dietary Glucose Ameliorates Impaired Intestinal Development and Immune 
      Homeostasis Disorders Induced by Chronic Cold Stress in Pig Model.
LID - 10.3390/ijms23147730 [doi]
LID - 7730
AB  - Endotherms are easily challenged by chronic cold stress. In this study, the 
      development and injury of the small intestine in the Min pig model and Yorkshire 
      pig model under chronic cold stress, and the molecular mechanisms by which 
      glucose supplementation reduces small intestinal mucosal damage were 
      investigated. The results showed that morphological structure lesions of the 
      jejunal mucosa and ileal mucosa were visible in Yorkshire pigs under chronic cold 
      stress. Meanwhile, the Occludin mRNA and protein expression in jejunal mucosa of 
      Yorkshire pigs was decreased. Chronic cold stress enhanced the expression of 
      Toll-like receptor 4 (TLR4), the myeloid differentiation main response 88 
      (MyD88), nucleotide-binding domain and leucine-rich repeat protein 3 (NLRP3), 
      cleaved caspase-1, mature-IL-1beta, and high-mobility group box 1 (HMGB 1) mRNA and 
      protein expression in jejunal mucosa of Yorkshire pigs, whereas the mRNA and 
      protein of Bax was triggered in ileal mucosa. In Min pigs, no such deleterious 
      consequences were observed. Dietary glucose supplementation ameliorates small 
      intestinal mucosal injury, declined TLR4 and MyD88 expression in jejunal mucosa. 
      In conclusion, chronic cold stress induced the small intestinal mucosa damage in 
      Yorkshire pigs, whereas glucose supplementation mitigated the deleterious effects 
      of chronic cold stress on the small intestine.
FAU - Sun, Guodong
AU  - Sun G
AUID- ORCID: 0000-0002-6225-9910
AD  - Institute of Animal Nutrition, Northeast Agricultural University, Harbin 150030, 
      China.
FAU - Song, Xin
AU  - Song X
AD  - Institute of Animal Nutrition, Northeast Agricultural University, Harbin 150030, 
      China.
FAU - Zou, Yingbin
AU  - Zou Y
AD  - Institute of Animal Nutrition, Northeast Agricultural University, Harbin 150030, 
      China.
FAU - Teng, Teng
AU  - Teng T
AUID- ORCID: 0000-0003-0747-5933
AD  - Institute of Animal Nutrition, Northeast Agricultural University, Harbin 150030, 
      China.
FAU - Jiang, Lin
AU  - Jiang L
AD  - Institute of Animal Nutrition, Northeast Agricultural University, Harbin 150030, 
      China.
FAU - Shi, Baoming
AU  - Shi B
AUID- ORCID: 0000-0001-8560-4564
AD  - Institute of Animal Nutrition, Northeast Agricultural University, Harbin 150030, 
      China.
LA  - eng
GR  - 2021YFD1300403/National Key R&D Program of China/
GR  - 2021ZX12B08-02/Major Program of Heilongjiang Province of China/
PT  - Journal Article
DEP - 20220713
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Myeloid Differentiation Factor 88)
RN  - 0 (RNA, Messenger)
RN  - 0 (Toll-Like Receptor 4)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Animals
MH  - Cold-Shock Response
MH  - Glucose/metabolism
MH  - Homeostasis
MH  - Intestinal Mucosa/metabolism
MH  - *Myeloid Differentiation Factor 88/metabolism
MH  - RNA, Messenger/metabolism
MH  - Swine
MH  - *Toll-Like Receptor 4/genetics/metabolism
PMC - PMC9317271
OTO - NOTNLM
OT  - TLR4/MyD88 signal pathway
OT  - chronic cold stress
OT  - glucose
OT  - pyroptosis
OT  - small intestinal mucosa
COIS- The authors declare no conflict of interest. The funders had no role in the 
      design of the study; in the collection, analyses, or interpretation of data; in 
      the writing of the manuscript; or in the decision to publish the results.
EDAT- 2022/07/28 06:00
MHDA- 2022/07/29 06:00
PMCR- 2022/07/13
CRDT- 2022/07/27 01:23
PHST- 2022/06/22 00:00 [received]
PHST- 2022/07/11 00:00 [revised]
PHST- 2022/07/11 00:00 [accepted]
PHST- 2022/07/27 01:23 [entrez]
PHST- 2022/07/28 06:00 [pubmed]
PHST- 2022/07/29 06:00 [medline]
PHST- 2022/07/13 00:00 [pmc-release]
AID - ijms23147730 [pii]
AID - ijms-23-07730 [pii]
AID - 10.3390/ijms23147730 [doi]
PST - epublish
SO  - Int J Mol Sci. 2022 Jul 13;23(14):7730. doi: 10.3390/ijms23147730.