PMID- 35887264
OWN - NLM
STAT- MEDLINE
DCOM- 20220728
LR  - 20220731
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 23
IP  - 14
DP  - 2022 Jul 18
TI  - CaMKII Splice Variants in Vascular Smooth Muscle Cells: The Next Step or 
      Redundancy?
LID - 10.3390/ijms23147916 [doi]
LID - 7916
AB  - Vascular smooth muscle cells (VSMCs) help to maintain the normal physiological 
      contractility of arterial vessels to control blood pressure; they can also 
      contribute to vascular disease such as atherosclerosis. 
      Ca(2+)/calmodulin-dependent kinase II (CaMKII), a multifunctional enzyme with 
      four isoforms and multiple alternative splice variants, contributes to numerous 
      functions within VSMCs. The role of these isoforms has been widely studied across 
      numerous tissue types; however, their functions are still largely unknown within 
      the vasculature. Even more understudied is the role of the different splice 
      variants of each isoform in such signaling pathways. This review evaluates the 
      role of the different CaMKII splice variants in vascular pathological and 
      physiological mechanisms, aiming to show the need for more research to highlight 
      both the deleterious and protective functions of the various splice variants.
FAU - Roberts-Craig, Finn T
AU  - Roberts-Craig FT
AD  - Department of Medicine, University of Otago, Dunedin 9016, New Zealand.
AD  - Department of Physiology, School of Biomedical Sciences, University of Otago, 
      Dunedin 9016, New Zealand.
FAU - Worthington, Luke P
AU  - Worthington LP
AUID- ORCID: 0000-0002-6884-9348
AD  - Department of Physiology, School of Biomedical Sciences, University of Otago, 
      Dunedin 9016, New Zealand.
AD  - HeartOtago, University of Otago, Dunedin 9016, New Zealand.
FAU - O'Hara, Samuel P
AU  - O'Hara SP
AD  - Department of Physiology, School of Biomedical Sciences, University of Otago, 
      Dunedin 9016, New Zealand.
AD  - HeartOtago, University of Otago, Dunedin 9016, New Zealand.
FAU - Erickson, Jeffrey R
AU  - Erickson JR
AUID- ORCID: 0000-0001-5918-1991
AD  - Department of Physiology, School of Biomedical Sciences, University of Otago, 
      Dunedin 9016, New Zealand.
AD  - HeartOtago, University of Otago, Dunedin 9016, New Zealand.
FAU - Heather, Alison K
AU  - Heather AK
AD  - Department of Physiology, School of Biomedical Sciences, University of Otago, 
      Dunedin 9016, New Zealand.
AD  - HeartOtago, University of Otago, Dunedin 9016, New Zealand.
FAU - Ashley, Zoe
AU  - Ashley Z
AUID- ORCID: 0000-0001-8563-5600
AD  - Department of Physiology, School of Biomedical Sciences, University of Otago, 
      Dunedin 9016, New Zealand.
AD  - HeartOtago, University of Otago, Dunedin 9016, New Zealand.
LA  - eng
GR  - 1772/National Heart Foundation New Zealand/
GR  - FRC/University of Otago, Medical School Dean's research scholarship/
PT  - Journal Article
PT  - Review
DEP - 20220718
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Protein Isoforms)
RN  - EC 2.7.11.17 (Calcium-Calmodulin-Dependent Protein Kinase Type 2)
SB  - IM
MH  - *Calcium-Calmodulin-Dependent Protein Kinase Type 2/genetics/metabolism
MH  - *Muscle, Smooth, Vascular/metabolism
MH  - Myocytes, Smooth Muscle/metabolism
MH  - Protein Isoforms/genetics/metabolism
MH  - Signal Transduction/physiology
PMC - PMC9318135
OTO - NOTNLM
OT  - CaMKII delta
OT  - CaMKII gamma
OT  - vascular
COIS- The authors declare no conflict of interest. The funders had no role in the 
      writing of the manuscript or in the decision to publish it.
EDAT- 2022/07/28 06:00
MHDA- 2022/07/29 06:00
PMCR- 2022/07/18
CRDT- 2022/07/27 01:24
PHST- 2022/06/21 00:00 [received]
PHST- 2022/07/11 00:00 [revised]
PHST- 2022/07/12 00:00 [accepted]
PHST- 2022/07/27 01:24 [entrez]
PHST- 2022/07/28 06:00 [pubmed]
PHST- 2022/07/29 06:00 [medline]
PHST- 2022/07/18 00:00 [pmc-release]
AID - ijms23147916 [pii]
AID - ijms-23-07916 [pii]
AID - 10.3390/ijms23147916 [doi]
PST - epublish
SO  - Int J Mol Sci. 2022 Jul 18;23(14):7916. doi: 10.3390/ijms23147916.