PMID- 35887379
OWN - NLM
STAT- MEDLINE
DCOM- 20220728
LR  - 20220731
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 23
IP  - 14
DP  - 2022 Jul 21
TI  - Different Roles of Dendritic Cells for Chronic Rhinosinusitis Treatment According 
      to Phenotype.
LID - 10.3390/ijms23148032 [doi]
LID - 8032
AB  - Dendritic cells (DCs) are antigen-presenting cells derived from the bone marrow 
      that play an important role in the association between the innate and adaptive 
      immune responses. The onset and development of chronic rhinosinusitis (CRS) 
      involve a serious imbalance in immune regulation and mechanical dysfunction 
      caused by an abnormal remodeling process. Recent studies have shown that an 
      increase in DCs in CRS and their function of shaping the nasal mucosal immune 
      response may play an important role in the pathogenesis of CRS. In this review, 
      we discuss DC subsets in mice and humans, as well as the function of DCs in the 
      nasal sinus mucosa. In addition, the mechanism by which DCs can be used as 
      targets for therapeutic intervention for CRS and potential future research 
      directions are also discussed.
FAU - Tai, Junhu
AU  - Tai J
AUID- ORCID: 0000-0003-1491-9889
AD  - Department of Otorhinolaryngology-Head & Neck Surgery, College of Medicine, Korea 
      University, Seoul 02841, Korea.
FAU - Kwak, Jiwon
AU  - Kwak J
AD  - Department of Otorhinolaryngology-Head & Neck Surgery, College of Medicine, Korea 
      University, Seoul 02841, Korea.
FAU - Han, Munsoo
AU  - Han M
AUID- ORCID: 0000-0003-1359-6248
AD  - Department of Otorhinolaryngology-Head & Neck Surgery, College of Medicine, Korea 
      University, Seoul 02841, Korea.
AD  - Mucosal Immunology Institute, College of Medicine, Korea University, Seoul 02841, 
      Korea.
FAU - Kim, Tae Hoon
AU  - Kim TH
AD  - Department of Otorhinolaryngology-Head & Neck Surgery, College of Medicine, Korea 
      University, Seoul 02841, Korea.
AD  - Mucosal Immunology Institute, College of Medicine, Korea University, Seoul 02841, 
      Korea.
LA  - eng
GR  - 2017R1A2B2003575 and NRF-2020R1A2C1006398/Ministry of Science ICT and Future 
      Planning/
GR  - IITP-2022-2020-0-01819/ICT Creative Consilience program/
GR  - HI17C0387/Korea Health Technology R&D Project/
PT  - Journal Article
PT  - Review
DEP - 20220721
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
SB  - IM
MH  - Animals
MH  - Chronic Disease
MH  - Dendritic Cells
MH  - Humans
MH  - Mice
MH  - Phenotype
MH  - *Rhinitis/genetics
MH  - *Sinusitis/genetics
PMC - PMC9323853
OTO - NOTNLM
OT  - chronic rhinosinusitis
OT  - dendritic cells
OT  - immunity
OT  - phenotype
COIS- The authors declare no conflict of interest.
EDAT- 2022/07/28 06:00
MHDA- 2022/07/29 06:00
PMCR- 2022/07/21
CRDT- 2022/07/27 01:25
PHST- 2022/06/29 00:00 [received]
PHST- 2022/07/20 00:00 [revised]
PHST- 2022/07/20 00:00 [accepted]
PHST- 2022/07/27 01:25 [entrez]
PHST- 2022/07/28 06:00 [pubmed]
PHST- 2022/07/29 06:00 [medline]
PHST- 2022/07/21 00:00 [pmc-release]
AID - ijms23148032 [pii]
AID - ijms-23-08032 [pii]
AID - 10.3390/ijms23148032 [doi]
PST - epublish
SO  - Int J Mol Sci. 2022 Jul 21;23(14):8032. doi: 10.3390/ijms23148032.