PMID- 35887397
OWN - NLM
STAT- MEDLINE
DCOM- 20220728
LR  - 20230308
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 23
IP  - 14
DP  - 2022 Jul 21
TI  - Tumor-Stroma Ratio and Programmed Cell Death Ligand 1 Expression in Preoperative 
      Biopsy and Matched Laryngeal Carcinoma Surgical Specimen.
LID - 10.3390/ijms23148053 [doi]
LID - 8053
AB  - Programmed cell death ligand 1 (PD-L1) seems to rely on close relations between 
      neoplastic and immune cells in the tumor microenvironment. Tumor to stroma ratio 
      (TSR) has been associated with prognosis in different malignancies. The aims of 
      this exploratory investigation were to analyze for the first time the: (i) 
      association between TSR, PD-L1 expression and other clinical-pathological 
      features in laryngeal squamous cell carcinoma (LSCC) biopsies and paired surgical 
      specimens; (ii) prognostic and predictive role of TSR and PD-L1. TSR, PD-L1 
      expression (in terms of combined positive score [CPS]), and other 
      clinical-pathological features were analyzed in biopsies and surgical specimens 
      of 43 consecutive LSCC cases. A CPS < 1 evaluated on surgical specimens was 
      associated with a low TSR (stroma rich) on both biopsies and surgical specimens 
      (p = 0.0143 and p = 0.0063). Low TSR showed a significant negative prognostic 
      value when evaluated on both biopsies and surgical specimens (HR = 8.808, p = 
      0.0003 and HR = 11.207, p = 0.0002). CPS >/= 1 appeared to be a favorable 
      prognostic factor (HR = 0.100, p = 0.0265). The association between bioptic and 
      surgical specimen TSR and PD-L1 expression should be further investigated for a 
      potential impact on targeted treatments, also with regard to immunotherapeutic 
      protocols.
FAU - Alessandrini, Lara
AU  - Alessandrini L
AD  - Department of Medicine DIMED, University of Padova, Via Giustiniani 2, 35128 
      Padova, Italy.
FAU - Franz, Leonardo
AU  - Franz L
AD  - Department of Neuroscience DNS, Otolaryngology Section, University of Padova, Via 
      Giustiniani 2, 35128 Padova, Italy.
AD  - Guided Therapeutics (GTx) Program International Scholar, University Health 
      Network (UHN), Toronto, ON M5G2C4, Canada.
FAU - Sbaraglia, Marta
AU  - Sbaraglia M
AD  - Department of Medicine DIMED, University of Padova, Via Giustiniani 2, 35128 
      Padova, Italy.
FAU - Saccardo, Tommaso
AU  - Saccardo T
AUID- ORCID: 0000-0002-8349-9569
AD  - Department of Neuroscience DNS, Otolaryngology Section, University of Padova, Via 
      Giustiniani 2, 35128 Padova, Italy.
FAU - Cappello, Filippo
AU  - Cappello F
AD  - Department of Medicine DIMED, University of Padova, Via Giustiniani 2, 35128 
      Padova, Italy.
FAU - Drigo, Alessandro
AU  - Drigo A
AD  - Department of Neuroscience DNS, Otolaryngology Section, University of Padova, Via 
      Giustiniani 2, 35128 Padova, Italy.
FAU - Frigo, Anna Chiara
AU  - Frigo AC
AUID- ORCID: 0000-0001-9705-4459
AD  - Department of Cardiac-Thoracic-Vascular Sciences and Public Health, University of 
      Padova, Via Giustiniani 2, 35128 Padova, Italy.
FAU - Marioni, Gino
AU  - Marioni G
AUID- ORCID: 0000-0001-8751-0588
AD  - Department of Neuroscience DNS, Otolaryngology Section, University of Padova, Via 
      Giustiniani 2, 35128 Padova, Italy.
LA  - eng
GR  - No. DOR2138454/21 (G. Marioni)/University of Padua/
PT  - Journal Article
DEP - 20220721
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (B7-H1 Antigen)
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Ligands)
SB  - IM
MH  - Apoptosis
MH  - B7-H1 Antigen/metabolism
MH  - Biomarkers, Tumor/metabolism
MH  - Biopsy
MH  - *Head and Neck Neoplasms
MH  - Humans
MH  - *Laryngeal Neoplasms/surgery
MH  - Ligands
MH  - Squamous Cell Carcinoma of Head and Neck
MH  - Tumor Microenvironment
PMC - PMC9319127
OTO - NOTNLM
OT  - PD-L1
OT  - biopsy
OT  - laryngeal squamous cell carcinoma
OT  - prognosis
OT  - programmed cell death ligand 1
OT  - tumor-stroma ratio
COIS- The authors declare no conflict of interest. The funders had no role in the 
      design of the study; in the collection, analyses, or interpretation of data; in 
      the writing of the manuscript, or in the decision to publish the results.
EDAT- 2022/07/28 06:00
MHDA- 2022/07/29 06:00
PMCR- 2022/07/21
CRDT- 2022/07/27 01:25
PHST- 2022/06/12 00:00 [received]
PHST- 2022/07/15 00:00 [revised]
PHST- 2022/07/19 00:00 [accepted]
PHST- 2022/07/27 01:25 [entrez]
PHST- 2022/07/28 06:00 [pubmed]
PHST- 2022/07/29 06:00 [medline]
PHST- 2022/07/21 00:00 [pmc-release]
AID - ijms23148053 [pii]
AID - ijms-23-08053 [pii]
AID - 10.3390/ijms23148053 [doi]
PST - epublish
SO  - Int J Mol Sci. 2022 Jul 21;23(14):8053. doi: 10.3390/ijms23148053.