PMID- 35887636
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230308
IS  - 2075-4426 (Print)
IS  - 2075-4426 (Electronic)
IS  - 2075-4426 (Linking)
VI  - 12
IP  - 7
DP  - 2022 Jul 14
TI  - Evaluation of Subclinical Vascular Disease in Diabetic Kidney Disease: A Tool for 
      Personalization of Management of a High-Risk Population.
LID - 10.3390/jpm12071139 [doi]
LID - 1139
AB  - Background: Patients with diabetic kidney disease (DKD) are at increased risk for 
      cardiovascular events but traditional risk factors do not fully explain this 
      association. Evaluation of subclinical vascular disease might improve risk 
      stratification and management of these patients. The aim of the study was to 
      compare the prevalence of markers of arterial stiffness, carotid atherosclerosis 
      and peripheral arterial disease between patients with DKD and patients with type 
      2 diabetes mellitus (T2DM) and preserved kidney function. Methods: We 
      prospectively enrolled patients with DKD and age- and gender-matched patients 
      with T2DM but without DKD (estimated glomerular filtration rate < and >/=60 
      mL/min/1.73 m2, respectively). The presence of arterial stiffness was evaluated 
      by measuring pulse wave velocity (PWV), augmentation index (AIx), AIx adjusted to 
      a heart rate of 75 beats/min (AIx@75) and central systolic, diastolic, pulse and 
      mean blood pressure. The presence of carotid atherosclerosis was evaluated by 
      measuring carotid stenosis, carotid intima-media thickness and maximal plaque 
      thickness. The presence of PAD was evaluated with the measurement of 
      ankle-brachial index (ABI). Results: Forty patients with T2DM were included in 
      the study (mean age 71.6 +/- 8.9 years). The prevalence of cardiovascular risk 
      factors was similar in patients with and without DKD. PWV was higher in the 
      former (9.8 +/- 5.5 and 6.6 +/- 4.4 m/s, respectively; p < 0.05) and carotid stenosis 
      of the left carotid artery was also greater in patients with DKD (36.5 +/- 12.6 and 
      22.1 +/- 17.2%, respectively; p < 0.05). Other markers of arterial stiffness and 
      carotid atherosclerosis and ABI did not differ between patients with DKD and 
      those without DKD. Conclusions: Patients with DKD appear to have more pronounced 
      arterial stiffness and carotid atherosclerosis than patients with T2DM and 
      preserved kidney function despite the similar prevalence of traditional 
      cardiovascular risk factors in the two groups. Therefore, evaluating the presence 
      of subclinical vascular disease in these patients could be a useful tool for the 
      personalization of their management.
FAU - Kourtidou, Christodoula
AU  - Kourtidou C
AD  - First Propedeutic Department of Internal Medicine, Medical School, Aristotle 
      University of Thessaloniki, AHEPA Hospital, 1 Stilponos Kyriakidi Street, 54636 
      Thessaloniki, Greece.
FAU - Rafailidis, Vasileios
AU  - Rafailidis V
AUID- ORCID: 0000-0002-0284-4106
AD  - Department of Radiology, Medical School, Aristotle University of Thessaloniki, 
      AHEPA Hospital, 54636 Thessaloniki, Greece.
FAU - Varouktsi, Garyfallia
AU  - Varouktsi G
AD  - Department of Nephrology, Medical School, Aristotle University of Thessaloniki, 
      AHEPA Hospital, 54636 Thessaloniki, Greece.
FAU - Kanakis, Efthimios
AU  - Kanakis E
AD  - First Propedeutic Department of Internal Medicine, Medical School, Aristotle 
      University of Thessaloniki, AHEPA Hospital, 1 Stilponos Kyriakidi Street, 54636 
      Thessaloniki, Greece.
FAU - Liakopoulos, Vassilios
AU  - Liakopoulos V
AUID- ORCID: 0000-0002-7564-2724
AD  - Department of Nephrology, Medical School, Aristotle University of Thessaloniki, 
      AHEPA Hospital, 54636 Thessaloniki, Greece.
FAU - Vyzantiadis, Timoleon-Achilleas
AU  - Vyzantiadis TA
AUID- ORCID: 0000-0002-2915-6098
AD  - First Department of Microbiology, Medical School, Aristotle University of 
      Thessaloniki, 54124 Thessaloniki, Greece.
FAU - Stangou, Maria
AU  - Stangou M
AUID- ORCID: 0000-0003-2496-9863
AD  - Department of Nephrology, Medical School, Aristotle University of Thessaloniki, 
      Hippokration Hospital, 54642 Thessaloniki, Greece.
FAU - Marinaki, Smaragdi
AU  - Marinaki S
AD  - Department of Nephrology and Renal Transplantation, Medical School, National and 
      Kapodistrian University of Athens, Laiko Hospital, 11527 Athens, Greece.
FAU - Tziomalos, Konstantinos
AU  - Tziomalos K
AUID- ORCID: 0000-0002-3172-1594
AD  - First Propedeutic Department of Internal Medicine, Medical School, Aristotle 
      University of Thessaloniki, AHEPA Hospital, 1 Stilponos Kyriakidi Street, 54636 
      Thessaloniki, Greece.
LA  - eng
PT  - Journal Article
DEP - 20220714
PL  - Switzerland
TA  - J Pers Med
JT  - Journal of personalized medicine
JID - 101602269
PMC - PMC9319005
OTO - NOTNLM
OT  - ankle-brachial index
OT  - arterial stiffness
OT  - cardiovascular disease
OT  - carotid atherosclerosis
OT  - diabetic kidney disease
OT  - diabetic nephropathy
OT  - peripheral arterial disease
OT  - personalization
OT  - pulse wave velocity
OT  - type 2 diabetes mellitus
COIS- The authors declare no conflict of interest.
EDAT- 2022/07/28 06:00
MHDA- 2022/07/28 06:01
PMCR- 2022/07/14
CRDT- 2022/07/27 01:26
PHST- 2022/06/19 00:00 [received]
PHST- 2022/07/01 00:00 [revised]
PHST- 2022/07/08 00:00 [accepted]
PHST- 2022/07/27 01:26 [entrez]
PHST- 2022/07/28 06:00 [pubmed]
PHST- 2022/07/28 06:01 [medline]
PHST- 2022/07/14 00:00 [pmc-release]
AID - jpm12071139 [pii]
AID - jpm-12-01139 [pii]
AID - 10.3390/jpm12071139 [doi]
PST - epublish
SO  - J Pers Med. 2022 Jul 14;12(7):1139. doi: 10.3390/jpm12071139.