PMID- 35887659
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220731
IS  - 2075-4426 (Print)
IS  - 2075-4426 (Electronic)
IS  - 2075-4426 (Linking)
VI  - 12
IP  - 7
DP  - 2022 Jul 18
TI  - Allergic Asthma in the Era of Personalized Medicine.
LID - 10.3390/jpm12071162 [doi]
LID - 1162
AB  - Allergic asthma is the most common asthma phenotype and is characterized by IgE 
      sensitization to airborne allergens and subsequent typical asthmatic symptoms 
      after exposure. A form of type 2 (T2) airway inflammation underlies allergic 
      asthma. It usually arises in childhood and is accompanied by multimorbidity 
      presenting with the occurrence of other atopic diseases, such as atopic 
      dermatitis and allergic rhinitis. Diagnosis of the allergic endotype is based on 
      in vivo (skin prick tests) and/or in vitro (allergen-specific IgE levels, 
      component-resolved diagnosis (CRD)) documentation of allergic sensitization. 
      Biomarkers identifying patients with allergic asthma include total immunoglobulin 
      E (IgE) levels, fractional exhaled nitric oxide (FeNO) and serum eosinophil 
      counts. The treatment of allergic asthma is a complex procedure and requires a 
      patient-tailored approach. Besides environmental control involving allergen 
      avoidance measurements and cornerstone pharmacological interventions based on 
      inhaled drugs, allergen-specific immunotherapy (AIT) and biologics are now at the 
      forefront when it comes to personalized management of asthma. The current review 
      aims to shed light on the distinct phenotype of allergic asthma, ranging over its 
      current definition, clinical characteristics, pathophysiology and biomarkers, as 
      well as its treatment options in the era of precision medicine.
FAU - Papapostolou, Niki
AU  - Papapostolou N
AUID- ORCID: 0000-0003-3950-3089
AD  - Allergy Unit, 2nd Department of Dermatology and Venereology, Medical School, 
      National and Kapodistrian University of Athens, "Attikon" University Hospital, 
      12462 Athens, Greece.
FAU - Makris, Michael
AU  - Makris M
AD  - Allergy Unit, 2nd Department of Dermatology and Venereology, Medical School, 
      National and Kapodistrian University of Athens, "Attikon" University Hospital, 
      12462 Athens, Greece.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20220718
PL  - Switzerland
TA  - J Pers Med
JT  - Journal of personalized medicine
JID - 101602269
PMC - PMC9321181
OTO - NOTNLM
OT  - allergen-specific immunotherapy
OT  - allergic asthma
OT  - allergic phenotype
OT  - asthma
OT  - biomarkers
COIS- The authors declare no conflict of interest.
EDAT- 2022/07/28 06:00
MHDA- 2022/07/28 06:01
PMCR- 2022/07/18
CRDT- 2022/07/27 01:26
PHST- 2022/06/06 00:00 [received]
PHST- 2022/07/08 00:00 [revised]
PHST- 2022/07/13 00:00 [accepted]
PHST- 2022/07/27 01:26 [entrez]
PHST- 2022/07/28 06:00 [pubmed]
PHST- 2022/07/28 06:01 [medline]
PHST- 2022/07/18 00:00 [pmc-release]
AID - jpm12071162 [pii]
AID - jpm-12-01162 [pii]
AID - 10.3390/jpm12071162 [doi]
PST - epublish
SO  - J Pers Med. 2022 Jul 18;12(7):1162. doi: 10.3390/jpm12071162.