PMID- 35887939
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220731
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 11
IP  - 14
DP  - 2022 Jul 19
TI  - Assessing Patients with Alpha-1 Antitrypsin Deficiency for Corneal Refractive 
      Surgery: A Review and Clinical Experience.
LID - 10.3390/jcm11144175 [doi]
LID - 4175
AB  - Alpha-1 Antitrypsin Deficiency (AATD) is an autosomal inheritable disorder that 
      impairs the protease inhibitor alpha-1 antitrypsin. This disorder presents with 
      various systemic effects, including liver cirrhosis, centrilobular emphysema, and 
      ocular manifestations. Performing corneal refractive surgery in patients with 
      AATD raises concerns regarding the increased rates of corneal erosions, corneal 
      ulcerations, potential developing descemetoceles, and other ocular 
      manifestations. Patient outcomes for laser-assisted in situ keratomileuses 
      (LASIK), photorefractive keratectomy (PRK), small incision lenticule extraction 
      (SMILE), and other ocular corrective surgeries are lacking in this population. 
      This article provides experiences performing corneal refractive surgery, 
      discusses the current understanding of AATD, including its ocular manifestations, 
      and explores factors to consider when evaluating patients for corneal procedures. 
      The aim of this paper is to address the manifestations of AATD prior to 
      performing corrective vision surgery.
FAU - Moshirfar, Majid
AU  - Moshirfar M
AUID- ORCID: 0000-0003-1024-6250
AD  - Hoopes Vision Research Center, Hoopes Vision, 11820 S. State St. #200, Draper, UT 
      84020, USA.
AD  - John A. Moran Eye Center, University of Utah School of Medicine, Salt Lake City, 
      UT 84132, USA.
AD  - Utah Lions Eye Bank, Murray, UT 84107, USA.
FAU - Kelkar, Neil
AU  - Kelkar N
AD  - College of Medicine, University of Arizona College of Medicine-Phoenix, Phoenix, 
      AZ 85004, USA.
FAU - Ronquillo, Yasmyne C
AU  - Ronquillo YC
AUID- ORCID: 0000-0002-8852-4380
AD  - Hoopes Vision Research Center, Hoopes Vision, 11820 S. State St. #200, Draper, UT 
      84020, USA.
AD  - Olivera Lab, School of Biological Sciences, University of Utah, Salt Lake City, 
      UT 84112, USA.
FAU - Hoopes, Phillip C
AU  - Hoopes PC
AUID- ORCID: 0000-0002-2567-8331
AD  - Hoopes Vision Research Center, Hoopes Vision, 11820 S. State St. #200, Draper, UT 
      84020, USA.
LA  - eng
PT  - Journal Article
DEP - 20220719
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC9317581
OTO - NOTNLM
OT  - LASIK
OT  - PRK
OT  - SMILE
OT  - alpha-1 antitrypsin
OT  - alpha-1 antitrypsin deficiency
OT  - cornea
OT  - corneal erosion
OT  - corneal ulcer
OT  - descemetocele
OT  - refractive surgery
COIS- The authors declare no conflict of interest.
EDAT- 2022/07/28 06:00
MHDA- 2022/07/28 06:01
PMCR- 2022/07/19
CRDT- 2022/07/27 01:27
PHST- 2022/06/03 00:00 [received]
PHST- 2022/06/20 00:00 [revised]
PHST- 2022/07/13 00:00 [accepted]
PHST- 2022/07/27 01:27 [entrez]
PHST- 2022/07/28 06:00 [pubmed]
PHST- 2022/07/28 06:01 [medline]
PHST- 2022/07/19 00:00 [pmc-release]
AID - jcm11144175 [pii]
AID - jcm-11-04175 [pii]
AID - 10.3390/jcm11144175 [doi]
PST - epublish
SO  - J Clin Med. 2022 Jul 19;11(14):4175. doi: 10.3390/jcm11144175.