PMID- 35888595
OWN - NLM
STAT- MEDLINE
DCOM- 20220728
LR  - 20230308
IS  - 1648-9144 (Electronic)
IS  - 1010-660X (Print)
IS  - 1010-660X (Linking)
VI  - 58
IP  - 7
DP  - 2022 Jun 30
TI  - TyG Index Performs Better Than HOMA-IR in Chinese Type 2 Diabetes Mellitus with a 
      BMI < 35 kg/m2: A Hyperglycemic Clamp Validated Study.
LID - 10.3390/medicina58070876 [doi]
LID - 876
AB  - Background and objectives: Chinese type 2 diabetes mellitus (T2DM) patients are 
      characterized by a low body mass index (BMI), and significant insulin resistance 
      (IR). The triglyceride glucose (TyG) index has not been studied as a means of 
      assessing IR in Chinese T2DM patients with a BMI < 35 kg/m2. Materials and 
      Methods: An open-label cross-sectional study recruited 102 Chinese T2DM patients 
      with a BMI < 35 kg/m2. The hyper-insulinemic euglycemic clamp, homeostatic model 
      assessment of IR (HOMA-IR), and TyG index were used to determine the level of IR. 
      Based on Pearson's correlations, glucose disposal rate (GDR), TyG index, and 
      HOMA-IR were analyzed. HOMA-IR and TyG index for IR were evaluated using multiple 
      linear regression and multivariate logistic regression analyses. On the basis of 
      the receiver operating characteristic (ROC) curve, the sensitivity, specificity, 
      and optimal cut-off value of HOMA-IR and the TyG index were determined. Results: 
      The mean values of GDR, HOMA-IR, and TyG index were 4.25 +/- 1.81, 8.05 +/- 7.98, and 
      8.12 +/- 0.86 mg/kg/min, respectively. Pearson's correlation coefficient was -0.418 
      between GDR and TyG index and -0.324 between GDR and HOMA-IR. ROC curve analysis 
      showed that, among both sexes, the TyG index was a better discriminator of IR 
      than HOMA-IR. The area under the ROC curve (AUC) of the TyG index (0.785, 
      0.691-0.879) was higher than that of HOMA-IR (0.73, 0.588-0.873) in all genders. 
      The optimal cut-off values of the TyG index and HOMA-IR were 7.99 and 3.39, 
      respectively. Conclusions: The TyG index showed more effectiveness in identifying 
      IR in Chinese T2DM patients with a BMI < 35 kg/m2 compared to HOMA-IR.
FAU - Luo, Ping
AU  - Luo P
AUID- ORCID: 0000-0003-4728-2415
AD  - Department of General Surgery, Third Xiangya Hospital, Central South University, 
      Changsha 410013, China.
FAU - Cao, Yaoquan
AU  - Cao Y
AD  - Department of General Surgery, Third Xiangya Hospital, Central South University, 
      Changsha 410013, China.
FAU - Li, Pengzhou
AU  - Li P
AD  - Department of General Surgery, Third Xiangya Hospital, Central South University, 
      Changsha 410013, China.
FAU - Li, Weizheng
AU  - Li W
AD  - Department of General Surgery, Third Xiangya Hospital, Central South University, 
      Changsha 410013, China.
FAU - Song, Zhi
AU  - Song Z
AD  - Department of General Surgery, Third Xiangya Hospital, Central South University, 
      Changsha 410013, China.
FAU - Fu, Zhibing
AU  - Fu Z
AD  - Department of General Surgery, Third Xiangya Hospital, Central South University, 
      Changsha 410013, China.
FAU - Zhou, Hui
AU  - Zhou H
AD  - Department of General Surgery, Third Xiangya Hospital, Central South University, 
      Changsha 410013, China.
FAU - Yi, Xianhao
AU  - Yi X
AD  - Department of General Surgery, Third Xiangya Hospital, Central South University, 
      Changsha 410013, China.
FAU - Zhu, Liyong
AU  - Zhu L
AUID- ORCID: 0000-0002-4666-8458
AD  - Department of General Surgery, Third Xiangya Hospital, Central South University, 
      Changsha 410013, China.
FAU - Zhu, Shaihong
AU  - Zhu S
AUID- ORCID: 0000-0001-6209-3132
AD  - Department of General Surgery, Third Xiangya Hospital, Central South University, 
      Changsha 410013, China.
LA  - eng
GR  - YX202102/Wisdom Accumulation and Talent Cultivation Project of the Third Xiangya 
      Hospital of Central South University/
PT  - Journal Article
DEP - 20220630
PL  - Switzerland
TA  - Medicina (Kaunas)
JT  - Medicina (Kaunas, Lithuania)
JID - 9425208
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
RN  - 0 (Triglycerides)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Biomarkers
MH  - Blood Glucose/analysis
MH  - Body Mass Index
MH  - China
MH  - Cross-Sectional Studies
MH  - *Diabetes Mellitus, Type 2/complications
MH  - Female
MH  - Glucose
MH  - Humans
MH  - *Insulin Resistance
MH  - Male
MH  - Triglycerides
PMC - PMC9325243
OTO - NOTNLM
OT  - HOMA-IR
OT  - TyG index
OT  - hyper-insulinemic euglycemic clamp
OT  - insulin resistance
OT  - type 2 diabetes mellitus
COIS- The authors declare no conflict of interest.
EDAT- 2022/07/28 06:00
MHDA- 2022/07/29 06:00
PMCR- 2022/06/30
CRDT- 2022/07/27 01:30
PHST- 2022/04/16 00:00 [received]
PHST- 2022/05/30 00:00 [revised]
PHST- 2022/06/25 00:00 [accepted]
PHST- 2022/07/27 01:30 [entrez]
PHST- 2022/07/28 06:00 [pubmed]
PHST- 2022/07/29 06:00 [medline]
PHST- 2022/06/30 00:00 [pmc-release]
AID - medicina58070876 [pii]
AID - medicina-58-00876 [pii]
AID - 10.3390/medicina58070876 [doi]
PST - epublish
SO  - Medicina (Kaunas). 2022 Jun 30;58(7):876. doi: 10.3390/medicina58070876.