PMID- 35889810
OWN - NLM
STAT- MEDLINE
DCOM- 20220728
LR  - 20220731
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 14
IP  - 14
DP  - 2022 Jul 12
TI  - Sword Bean (Canavalia gladiata) Pod Exerts Anti-Allergic and Anti-Inflammatory 
      Effects through Modulation of Th1/Th2 Cell Differentiation.
LID - 10.3390/nu14142853 [doi]
LID - 2853
AB  - Allergy is an immunoglobulin E (IgE)-mediated process, and its incidence and 
      prevalence have increased worldwide in recent years. Therapeutic agents for 
      allergic diseases are continuously being developed, but side effects follow when 
      used for a long-term use. Therefore, treatments based on natural products that 
      are safe for the body are urgently required. Sword bean (Canavalia gladiata) pod 
      (SBP) has been traditionally used to treat inflammatory diseases, but there is 
      still no scientific basis for its anti-allergic effect. Accordingly, this study 
      investigates the anti-allergic effect and its mechanism of SBP in vitro and in 
      vivo. SBP reduced the nitric oxide production and decreased mRNA and protein 
      expression of inflammatory mediates (inducible nitric oxide synthase (iNOS) and 
      cyclooxygenase-2 (COX-2)), and inhibited the phosphorylation of nuclear factor 
      kappa B (NF-kappaB), a major signaling molecule in the inflammatory response. 
      Additionally, SBP extract treatment inhibited 
      phosphatidylinositol-3-kinase/mammalian target of rapamycin (PI3K/mTOR) signaling 
      activity to further inhibit degranulation and allergy mediator generation and 
      control the balance of Th1/Th2 cells, which can induce an allergic reaction when 
      disrupted. Furthermore, the SBP extract exhibited anti-allergic effects in 
      anti-dinitrophenyl IgE-induced RBL-2H3 cells and ovalbumin-treated mice. These 
      findings have potential clinical implications for the treatment as well as 
      prevention of allergic diseases.
FAU - Hwang, Kyung-A
AU  - Hwang KA
AD  - Department of Agrofood Resources, National Institute of Agricultural Sciences, 
      Rural Development Administration, Wanju-gun 55365, Korea.
FAU - Hwang, Yu Jin
AU  - Hwang YJ
AD  - Department of Agrofood Resources, National Institute of Agricultural Sciences, 
      Rural Development Administration, Wanju-gun 55365, Korea.
FAU - Hwang, Hye-Jeong
AU  - Hwang HJ
AUID- ORCID: 0000-0002-1948-4442
AD  - Department of Agrofood Resources, National Institute of Agricultural Sciences, 
      Rural Development Administration, Wanju-gun 55365, Korea.
AD  - Department of Food and Biotechnology, Korea University, Sejong 30019, Korea.
FAU - Lee, Sang Hoon
AU  - Lee SH
AD  - Department of Food and Biotechnology, Korea University, Sejong 30019, Korea.
FAU - Kim, Young Jun
AU  - Kim YJ
AD  - Department of Food and Biotechnology, Korea University, Sejong 30019, Korea.
LA  - eng
GR  - PJ 01588401/Research Program for Agricultural Science & Technology 
      Development/
GR  - PJ 01588402/Research Program for Agricultural Science & Technology 
      Development/
PT  - Journal Article
DEP - 20220712
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 0 (Anti-Allergic Agents)
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Plant Extracts)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Animals
MH  - *Anti-Allergic Agents/pharmacology
MH  - Anti-Inflammatory Agents/pharmacology/therapeutic use
MH  - Canavalia/metabolism
MH  - Cell Differentiation
MH  - *Hypersensitivity/drug therapy
MH  - Immunoglobulin E/metabolism
MH  - Mammals/metabolism
MH  - Mice
MH  - Plant Extracts/pharmacology/therapeutic use
PMC - PMC9322724
OTO - NOTNLM
OT  - Canavalia gladiata
OT  - anti-allergic
OT  - anti-inflammatory
OT  - sword bean pod
COIS- The authors declare no conflict of interest.
EDAT- 2022/07/28 06:00
MHDA- 2022/07/29 06:00
PMCR- 2022/07/12
CRDT- 2022/07/27 01:36
PHST- 2022/06/08 00:00 [received]
PHST- 2022/06/29 00:00 [revised]
PHST- 2022/07/08 00:00 [accepted]
PHST- 2022/07/27 01:36 [entrez]
PHST- 2022/07/28 06:00 [pubmed]
PHST- 2022/07/29 06:00 [medline]
PHST- 2022/07/12 00:00 [pmc-release]
AID - nu14142853 [pii]
AID - nutrients-14-02853 [pii]
AID - 10.3390/nu14142853 [doi]
PST - epublish
SO  - Nutrients. 2022 Jul 12;14(14):2853. doi: 10.3390/nu14142853.