PMID- 35889874
OWN - NLM
STAT- MEDLINE
DCOM- 20221230
LR  - 20221230
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 14
IP  - 14
DP  - 2022 Jul 16
TI  - Healthberry 865((R)) and a Subset of Its Single Anthocyanins Attenuate Oxidative 
      Stress in Human Endothelial In Vitro Models.
LID - 10.3390/nu14142917 [doi]
LID - 2917
AB  - Oxidative stress and inflammation play a pivotal role in the development of 
      cardiovascular diseases, an ever-growing worldwide problem. As a 
      non-pharmacological approach, diet, especially a flavonoid-rich diet, showed 
      promising results in the reduction of cardiovascular diseases and alleviation of 
      their symptoms. In this study, in vitro systems based on human microvascular 
      endothelial cells (hmvEC) and human umbilical cord endothelial cells (HUVEC) were 
      established to determine the effect of Healthberry 865((R)) (HB) and ten of its 
      relating single anthocyanins on oxidative stress. Furthermore, five metabolites 
      were used in order to examine the effect of anthocyanin's most common breakdown 
      molecules. The results showed an effect of HB in both models after 24 h, as well 
      as most of its single anthocyanins. Cyanidin-rutinoside, peonidin-galactoside, 
      and petunidin-glucoside had a model-specific effect. For the metabolites, 
      phloroglucinaldeyhde (PGA) showed an effect in both models, while vanillic acid 
      (VA) only had an effect in HUVEC. When combined, a combination of several 
      anthocyanins did not have a cumulative effect, except for combining glucosides in 
      hmvEC. The combination of PGA and VA even revealed an inhibitive behavior. 
      Overall, the study demonstrates the antioxidative effect of HB and several of its 
      single anthocyanins and metabolites, which are partially model specific, and 
      coincides with animal studies.
FAU - Ockermann, Philipp
AU  - Ockermann P
AD  - Institute for Tissue Engineering and Regenerative Medicine, University Hospital 
      Wuerzburg, Roentgenring 11, 97070 Wuerzburg, Germany.
FAU - Lizio, Rosario
AU  - Lizio R
AD  - Evonik Operations GmbH, 63457 Hanau, Germany.
FAU - Hansmann, Jan
AU  - Hansmann J
AD  - Institute for Tissue Engineering and Regenerative Medicine, University Hospital 
      Wuerzburg, Roentgenring 11, 97070 Wuerzburg, Germany.
LA  - eng
GR  - none/Evonik Operations GmbH/
PT  - Journal Article
DEP - 20220716
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 0 (Anthocyanins)
RN  - 0 (Glucosides)
SB  - IM
MH  - Animals
MH  - Humans
MH  - *Anthocyanins/metabolism/pharmacology
MH  - *Cardiovascular Diseases
MH  - Endothelial Cells/metabolism
MH  - Glucosides/pharmacology
MH  - Oxidative Stress
PMC - PMC9325219
OTO - NOTNLM
OT  - HUVEC
OT  - anthocyanins
OT  - microvascular endothelial cells
OT  - reactive oxygen species
COIS- Rosario Lizio is employed at the Evonik Operations GmbH, which provided 
      Healthberry865(R) and the anthocyanins. The presented data were raised in 
      cooperation between Evonik Operations GmbH, and the university chair. This does 
      not alter the authors' adherence to all the MDPI policies on sharing data and 
      materials, as detailed online in the guide for authors. This did also not 
      influence the authors' adherence to good scientific practice or the choice of 
      publications for this review.
EDAT- 2022/07/28 06:00
MHDA- 2022/07/29 06:00
PMCR- 2022/07/16
CRDT- 2022/07/27 01:37
PHST- 2022/06/19 00:00 [received]
PHST- 2022/07/11 00:00 [revised]
PHST- 2022/07/14 00:00 [accepted]
PHST- 2022/07/27 01:37 [entrez]
PHST- 2022/07/28 06:00 [pubmed]
PHST- 2022/07/29 06:00 [medline]
PHST- 2022/07/16 00:00 [pmc-release]
AID - nu14142917 [pii]
AID - nutrients-14-02917 [pii]
AID - 10.3390/nu14142917 [doi]
PST - epublish
SO  - Nutrients. 2022 Jul 16;14(14):2917. doi: 10.3390/nu14142917.