PMID- 35889886
OWN - NLM
STAT- MEDLINE
DCOM- 20220728
LR  - 20220731
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 14
IP  - 14
DP  - 2022 Jul 17
TI  - Anti-Obesity Effects of Aqueous Extracts of Sunbanghwalmyung-Eum in High-Fat- and 
      High-Cholesterol-Diet-Induced Obese C57BL/6J Mice.
LID - 10.3390/nu14142929 [doi]
LID - 2929
AB  - Sunbanghwalmyung-eum (SBH) is a traditional herbal medicine that exhibits various 
      pharmacological properties, such as antioxidant, anti-inflammatory, and 
      anticancer activities. In this study, we investigated the systemic anti-obesity 
      effects of an aqueous extract of SBH in the liver, adipose, and muscle tissue 
      from high-fat and high-cholesterol diet (HFHCD)-induced obese C57BL/6J mice. 
      After 6 weeks of an HFHCD, the mice were continuously fed HFHC with oral 
      administration of SBH (100 mg/kg/day), Sim (simvastatin, 5 mg/kg/day, positive 
      control), or water (HFHC only) for another 6 weeks. Our results showed that SBH 
      attenuated the HFHCD-induced body weight gain and fat accumulation in the liver, 
      and improved plasma lipid levels, such as those of triglycerides (TGs), blood 
      total cholesterol (TC), and low-density lipoprotein (LDL-c). SBH and Sim 
      inhibited the inflammation accompanied by obesity via decreasing inflammatory 
      cytokine interleukin (IL)-1beta, tumor necrosis factor alpha (TNFalpha), and monocyte 
      chemoattractant protein 1 (MCP1). Moreover, SBH downregulated the expression of 
      protein levels of adipogenic-related factors, including peroxisome 
      proliferator-activated receptor gamma (PPARgamma) and CCAAT/enhancer-binding protein alpha 
      (C/EBPalpha), in the liver, adipose, and muscle tissue. The SBH and Sim treatment 
      also significantly upregulated the phosphorylation of AMP-activated protein 
      kinase alpha (AMPKalpha) in the liver and hormone-sensitive lipase (HSL) in the adipose 
      tissue. Overall, the effects of SBH on HFHCD-induced obesity were similar to or 
      more potent than those of simvastatin. These results indicated that SBH has great 
      potential as a therapeutic herbal medicine for obesity.
FAU - Kim, Hye-Lin
AU  - Kim HL
AD  - KM Science Research Division, Korea Institute of Oriental Medicine, Daejeon 
      34054, Korea.
FAU - Ahn, You Mee
AU  - Ahn YM
AD  - KM Science Research Division, Korea Institute of Oriental Medicine, Daejeon 
      34054, Korea.
FAU - Lee, So Min
AU  - Lee SM
AUID- ORCID: 0000-0003-3833-6792
AD  - KM Convergence Research Division, Korea Institute of Oriental Medicine, Daejeon 
      34054, Korea.
FAU - Seo, Chang-Seob
AU  - Seo CS
AUID- ORCID: 0000-0002-8156-446X
AD  - KM Science Research Division, Korea Institute of Oriental Medicine, Daejeon 
      34054, Korea.
FAU - Park, Seong-Hwan
AU  - Park SH
AD  - KM Science Research Division, Korea Institute of Oriental Medicine, Daejeon 
      34054, Korea.
FAU - Bang, Ok-Sun
AU  - Bang OS
AD  - KM Science Research Division, Korea Institute of Oriental Medicine, Daejeon 
      34054, Korea.
FAU - Jung, Jeeyoun
AU  - Jung J
AUID- ORCID: 0000-0002-9213-4748
AD  - KM Science Research Division, Korea Institute of Oriental Medicine, Daejeon 
      34054, Korea.
LA  - eng
GR  - KSN2022210/Korea Institute of Oriental Medicine/
PT  - Journal Article
DEP - 20220717
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 0 (Anti-Obesity Agents)
RN  - 0 (CCAAT-Enhancer-Binding Protein-alpha)
RN  - 0 (PPAR gamma)
RN  - 0 (Plant Extracts)
RN  - 059QF0KO0R (Water)
RN  - 97C5T2UQ7J (Cholesterol)
RN  - AGG2FN16EV (Simvastatin)
RN  - EC 2.7.11.31 (AMP-Activated Protein Kinases)
SB  - IM
MH  - AMP-Activated Protein Kinases/metabolism
MH  - Adipogenesis
MH  - Adipose Tissue/metabolism
MH  - Animals
MH  - *Anti-Obesity Agents/therapeutic use
MH  - CCAAT-Enhancer-Binding Protein-alpha/metabolism
MH  - Cholesterol/metabolism
MH  - Diet, High-Fat
MH  - *Hyperlipidemias/drug therapy
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Obese
MH  - Obesity/metabolism
MH  - PPAR gamma/metabolism
MH  - Plant Extracts/therapeutic use
MH  - Simvastatin/pharmacology
MH  - Water/metabolism
PMC - PMC9318667
OTO - NOTNLM
OT  - C57BL/6J mice
OT  - Sunbanghwalmyung-eum
OT  - high-fat high-cholesterol diet
OT  - obesity
COIS- The authors declare no conflict of interest.
EDAT- 2022/07/28 06:00
MHDA- 2022/07/29 06:00
PMCR- 2022/07/17
CRDT- 2022/07/27 01:37
PHST- 2022/06/15 00:00 [received]
PHST- 2022/07/08 00:00 [revised]
PHST- 2022/07/14 00:00 [accepted]
PHST- 2022/07/27 01:37 [entrez]
PHST- 2022/07/28 06:00 [pubmed]
PHST- 2022/07/29 06:00 [medline]
PHST- 2022/07/17 00:00 [pmc-release]
AID - nu14142929 [pii]
AID - nutrients-14-02929 [pii]
AID - 10.3390/nu14142929 [doi]
PST - epublish
SO  - Nutrients. 2022 Jul 17;14(14):2929. doi: 10.3390/nu14142929.