PMID- 35890217 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20220731 IS - 1999-4923 (Print) IS - 1999-4923 (Electronic) IS - 1999-4923 (Linking) VI - 14 IP - 7 DP - 2022 Jun 22 TI - Stimuli-Responsive Gold Nanocages for Cancer Diagnosis and Treatment. LID - 10.3390/pharmaceutics14071321 [doi] LID - 1321 AB - With advances in nanotechnology, various new drug delivery systems (DDSs) have emerged and played a key role in the diagnosis and treatment of cancers. Over the last two decades, gold nanocages (AuNCs) have been attracting considerable attention because of their outstanding properties. This review summarizes current advancements in endogenous, exogenous, and dual/multi-stimuli responsive AuNCs in drug delivery. This review focuses on the properties, clinical translation potential, and limitations of stimuli-responsive AuNCs for cancer diagnosis and treatment. FAU - Li, Chunming AU - Li C AD - Department of Pharmacy, Chongqing University Cancer Hospital, No. 181 Hanyu Road, Chongqing 400030, China. FAU - Zhao, Tengyue AU - Zhao T AD - School of Pharmaceutical Sciences, Zhengzhou University, No. 100 Kexue Avenue, Zhengzhou 450001, China. FAU - Li, Lixian AU - Li L AD - Department of Pharmacy, Chongqing University Cancer Hospital, No. 181 Hanyu Road, Chongqing 400030, China. FAU - Hu, Xiaogang AU - Hu X AD - Department of Pharmacy, Chongqing University Cancer Hospital, No. 181 Hanyu Road, Chongqing 400030, China. FAU - Li, Chao AU - Li C AD - Department of Pharmacy, Chongqing University Cancer Hospital, No. 181 Hanyu Road, Chongqing 400030, China. FAU - Chen, Wanyi AU - Chen W AD - Department of Pharmacy, Chongqing University Cancer Hospital, No. 181 Hanyu Road, Chongqing 400030, China. FAU - Hu, Yurong AU - Hu Y AUID- ORCID: 0000-0002-0354-7939 AD - School of Pharmaceutical Sciences, Zhengzhou University, No. 100 Kexue Avenue, Zhengzhou 450001, China. LA - eng GR - cstc2019jcyj-msxmX0035/the Natural Science Foundation of Chongqing, China/ GR - have no number/the Chongqing Clinical Pharmacy Key Specialties Construction Project/ GR - 81272563/the National Natural Science Foundation of China/ PT - Journal Article PT - Review DEP - 20220622 PL - Switzerland TA - Pharmaceutics JT - Pharmaceutics JID - 101534003 PMC - PMC9318695 OTO - NOTNLM OT - cancer OT - controlled release OT - diagnosis OT - gold nanocages OT - stimuli-responsive OT - treatment COIS- The authors declare no conflict of interest. EDAT- 2022/07/28 06:00 MHDA- 2022/07/28 06:01 PMCR- 2022/06/22 CRDT- 2022/07/27 01:38 PHST- 2022/05/26 00:00 [received] PHST- 2022/06/15 00:00 [revised] PHST- 2022/06/18 00:00 [accepted] PHST- 2022/07/27 01:38 [entrez] PHST- 2022/07/28 06:00 [pubmed] PHST- 2022/07/28 06:01 [medline] PHST- 2022/06/22 00:00 [pmc-release] AID - pharmaceutics14071321 [pii] AID - pharmaceutics-14-01321 [pii] AID - 10.3390/pharmaceutics14071321 [doi] PST - epublish SO - Pharmaceutics. 2022 Jun 22;14(7):1321. doi: 10.3390/pharmaceutics14071321.