PMID- 35891256
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220731
IS  - 2076-393X (Print)
IS  - 2076-393X (Electronic)
IS  - 2076-393X (Linking)
VI  - 10
IP  - 7
DP  - 2022 Jul 8
TI  - A Novel Therapeutic Tumor Vaccine Targeting MUC1 in Combination with PD-L1 
      Elicits Specific Anti-Tumor Immunity in Mice.
LID - 10.3390/vaccines10071092 [doi]
LID - 1092
AB  - Dendritic cells (DCs), as professional antigen-presenting cells (APCs), play a 
      key role in the initiation and regulation of humoral and cellular immunity. DC 
      vaccines loaded with different tumor-associated antigens (TAAs) have been widely 
      used to study their therapeutic effects on cancer. A number of clinical trials 
      have shown that DCs are safe as an antitumor vaccine and can activate certain 
      anti-tumor immune responses; however, the overall clinical efficacy of DC vaccine 
      is not satisfactory, so its efficacy needs to be enhanced. MUC1 is a TAA with 
      great potential, and the immune checkpoint PD-L1 also has great potential for 
      tumor treatment. Both of them are highly expressed on the surface of various 
      tumors. In this study, we generated a novel therapeutic MUC1-Vax tumor vaccine 
      based on the method of PD-L1-Vax vaccine we recently developed; this novel 
      PD-L1-containing MUC1-Vax vaccine demonstrated an elevated persistent anti-PD-L1 
      antibody production and elicited a much stronger protective cytotoxic T 
      lymphocyte (CTL) response in immunized mice. Furthermore, the MUC1-Vax vaccine 
      exhibited a significant therapeutic anti-tumor effect, which significantly 
      inhibited tumor growth by expressing a high MUC1(+) and PD-L1(+) level of LLC and 
      Panc02 tumor cells, and prolonged the survival of cancer-bearing animals. Taken 
      together, our study provides a new immunotherapy strategy for improving the 
      cross-presentation ability of therapeutic vaccine, which may be applicable to 
      pancreatic cancer, lung cancer and for targeting other types of solid tumors that 
      highly express MUC1 and PD-L1.
FAU - Pan, Jiayi
AU  - Pan J
AD  - School of Basic Medical Sciences, The Sixth Affiliated Hospital of Guangzhou 
      Medical University, Qingyuan People's Hospital, Guangzhou Medical University, 
      Guangzhou 510182, China.
AD  - Clinical Laboratory, Guangdong Provincial People's Hospital, Guangdong Academy of 
      Medical Science, Guangzhou 510080, China.
FAU - Zeng, Wuyi
AU  - Zeng W
AD  - School of Basic Medical Sciences, The Sixth Affiliated Hospital of Guangzhou 
      Medical University, Qingyuan People's Hospital, Guangzhou Medical University, 
      Guangzhou 510182, China.
FAU - Jia, Jiangtao
AU  - Jia J
AD  - School of Basic Medical Sciences, The Sixth Affiliated Hospital of Guangzhou 
      Medical University, Qingyuan People's Hospital, Guangzhou Medical University, 
      Guangzhou 510182, China.
FAU - Shi, Yi
AU  - Shi Y
AD  - School of Basic Medical Sciences, The Sixth Affiliated Hospital of Guangzhou 
      Medical University, Qingyuan People's Hospital, Guangzhou Medical University, 
      Guangzhou 510182, China.
FAU - Wang, Danni
AU  - Wang D
AD  - School of Basic Medical Sciences, The Sixth Affiliated Hospital of Guangzhou 
      Medical University, Qingyuan People's Hospital, Guangzhou Medical University, 
      Guangzhou 510182, China.
FAU - Dong, Jun
AU  - Dong J
AD  - School of Basic Medical Sciences, The Sixth Affiliated Hospital of Guangzhou 
      Medical University, Qingyuan People's Hospital, Guangzhou Medical University, 
      Guangzhou 510182, China.
FAU - Fang, Zixuan
AU  - Fang Z
AD  - School of Basic Medical Sciences, The Sixth Affiliated Hospital of Guangzhou 
      Medical University, Qingyuan People's Hospital, Guangzhou Medical University, 
      Guangzhou 510182, China.
FAU - He, Jiashan
AU  - He J
AD  - School of Basic Medical Sciences, The Sixth Affiliated Hospital of Guangzhou 
      Medical University, Qingyuan People's Hospital, Guangzhou Medical University, 
      Guangzhou 510182, China.
FAU - Yang, Xinyu
AU  - Yang X
AD  - School of Basic Medical Sciences, The Sixth Affiliated Hospital of Guangzhou 
      Medical University, Qingyuan People's Hospital, Guangzhou Medical University, 
      Guangzhou 510182, China.
FAU - Zhang, Rong
AU  - Zhang R
AD  - School of Basic Medical Sciences, The Sixth Affiliated Hospital of Guangzhou 
      Medical University, Qingyuan People's Hospital, Guangzhou Medical University, 
      Guangzhou 510182, China.
FAU - He, Menghua
AU  - He M
AD  - School of Basic Medical Sciences, The Sixth Affiliated Hospital of Guangzhou 
      Medical University, Qingyuan People's Hospital, Guangzhou Medical University, 
      Guangzhou 510182, China.
FAU - Huang, Maoping
AU  - Huang M
AD  - School of Basic Medical Sciences, The Sixth Affiliated Hospital of Guangzhou 
      Medical University, Qingyuan People's Hospital, Guangzhou Medical University, 
      Guangzhou 510182, China.
FAU - Fu, Bishi
AU  - Fu B
AD  - School of Basic Medical Sciences, The Sixth Affiliated Hospital of Guangzhou 
      Medical University, Qingyuan People's Hospital, Guangzhou Medical University, 
      Guangzhou 510182, China.
AD  - The State Key Laboratory of Respiratory Disease, Guangdong Provincial Key 
      Laboratory of Allergy & Clinical Immunology, Guangzhou 510260, China.
FAU - Zhong, Bei
AU  - Zhong B
AD  - School of Basic Medical Sciences, The Sixth Affiliated Hospital of Guangzhou 
      Medical University, Qingyuan People's Hospital, Guangzhou Medical University, 
      Guangzhou 510182, China.
FAU - Liu, Hui
AU  - Liu H
AUID- ORCID: 0000-0002-3770-7902
AD  - School of Basic Medical Sciences, The Sixth Affiliated Hospital of Guangzhou 
      Medical University, Qingyuan People's Hospital, Guangzhou Medical University, 
      Guangzhou 510182, China.
AD  - The State Key Laboratory of Respiratory Disease, Guangdong Provincial Key 
      Laboratory of Allergy & Clinical Immunology, Guangzhou 510260, China.
LA  - eng
GR  - 31770183/National Natural Science Foundation of China/
GR  - JCXKJS2021B04/Guangzhou Medical University/
GR  - 15001019002204/Guangzhou Medical University/
PT  - Journal Article
DEP - 20220708
PL  - Switzerland
TA  - Vaccines (Basel)
JT  - Vaccines
JID - 101629355
PMC - PMC9325010
OTO - NOTNLM
OT  - MUC1
OT  - PD-L1
OT  - dendritic cells
OT  - immunotherapy
OT  - tumor vaccine
COIS- The authors declare no conflict of interest.
EDAT- 2022/07/28 06:00
MHDA- 2022/07/28 06:01
PMCR- 2022/07/08
CRDT- 2022/07/27 01:43
PHST- 2022/05/19 00:00 [received]
PHST- 2022/06/26 00:00 [revised]
PHST- 2022/06/27 00:00 [accepted]
PHST- 2022/07/27 01:43 [entrez]
PHST- 2022/07/28 06:00 [pubmed]
PHST- 2022/07/28 06:01 [medline]
PHST- 2022/07/08 00:00 [pmc-release]
AID - vaccines10071092 [pii]
AID - vaccines-10-01092 [pii]
AID - 10.3390/vaccines10071092 [doi]
PST - epublish
SO  - Vaccines (Basel). 2022 Jul 8;10(7):1092. doi: 10.3390/vaccines10071092.