PMID- 35891275
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220731
IS  - 2076-393X (Print)
IS  - 2076-393X (Electronic)
IS  - 2076-393X (Linking)
VI  - 10
IP  - 7
DP  - 2022 Jul 12
TI  - Incidence and Characteristics of Adverse Events after COVID-19 Vaccination in a 
      Population-Based Programme.
LID - 10.3390/vaccines10071111 [doi]
LID - 1111
AB  - Compliance with vaccination is linked to its safety. In Italy, a plan to identify 
      people who could be at an increased risk of adverse events (AEs) was defined so 
      they could be vaccinated in a protected setting. We conducted an audit to 
      describe the process of AE risk assessment and occurrence in the Reggio Emilia 
      Province in Italy in people who received any of the four COVID-19 vaccines 
      currently used in Italy. Incidence of AEs was calculated by dose and type of 
      vaccine and type of setting (standard vs. protected). After 182,056 first doses 
      were administered, 521 (0.3%) AEs were reported. Most of the AEs were non-serious 
      (91.4%) and non-allergic (92.7%). The percentage of AEs was similar in both 
      settings: 0.3% in the standard setting and 0.2% in the protected setting. 
      However, the incidence of AEs was higher among those who had an allergist visit 
      than among those who did not (IR 666.7 vs. 124.9). All deaths (1.6/100.000) 
      occurred in standard settings and after the Pfizer and Moderna vaccines. The 
      incidence of AEs was lower after the second dose (IR 286.2 vs. 190.3), except for 
      mRNA vaccines, for which it was higher after the second dose (IR 169.8 vs. 
      251.8). Although vaccination in a protected medical setting could reassure 
      patients with a history of allergies to be vaccinated, allergy history and other 
      anamnestic information is not useful in predicting the risk of COVID-19 
      vaccine-related AEs in the general population.
FAU - Bonzano, Laura
AU  - Bonzano L
AUID- ORCID: 0000-0002-8933-4626
AD  - Dermatology Unit, Azienda Unita Sanitaria Locale-IRCCS di Reggio Emilia, 42122 
      Reggio Emilia, Italy.
FAU - Djuric, Olivera
AU  - Djuric O
AUID- ORCID: 0000-0002-8574-5938
AD  - Epidemiology Unit, Azienda Unita Sanitaria Locale-IRCCS di Reggio Emilia, 42122 
      Reggio Emilia, Italy.
AD  - Centre for Environmental, Nutritional and Genetic Epidemiology (CREAGEN), Section 
      of Public Health, Department of Biomedical, Metabolic and Neural Sciences, 
      University of Modena and Reggio Emilia, 41125 Modena, Italy.
FAU - Mancuso, Pamela
AU  - Mancuso P
AUID- ORCID: 0000-0003-1609-2440
AD  - Epidemiology Unit, Azienda Unita Sanitaria Locale-IRCCS di Reggio Emilia, 42122 
      Reggio Emilia, Italy.
FAU - Fares, Lidia
AU  - Fares L
AD  - Pharmaceutical Department, Azienda Unita Sanitaria Locale-IRCCS di Reggio Emilia, 
      42122 Reggio Emilia, Italy.
FAU - Brancaccio, Raffaele
AU  - Brancaccio R
AD  - Dermatology Unit, Azienda Unita Sanitaria Locale-IRCCS di Reggio Emilia, 42122 
      Reggio Emilia, Italy.
FAU - Ottone, Marta
AU  - Ottone M
AUID- ORCID: 0000-0003-1302-0329
AD  - Epidemiology Unit, Azienda Unita Sanitaria Locale-IRCCS di Reggio Emilia, 42122 
      Reggio Emilia, Italy.
FAU - Bisaccia, Eufemia
AU  - Bisaccia E
AD  - Public Health Unit, Azienda Unita Sanitaria Locale-IRCCS di Reggio Emilia, 42122 
      Reggio Emilia, Italy.
FAU - Vicentini, Massimo
AU  - Vicentini M
AUID- ORCID: 0000-0002-0227-2523
AD  - Epidemiology Unit, Azienda Unita Sanitaria Locale-IRCCS di Reggio Emilia, 42122 
      Reggio Emilia, Italy.
FAU - Cocconcelli, Alessia
AU  - Cocconcelli A
AD  - Dermatology Unit, Azienda Unita Sanitaria Locale-IRCCS di Reggio Emilia, 42122 
      Reggio Emilia, Italy.
FAU - Motolese, Alfonso
AU  - Motolese A
AUID- ORCID: 0000-0002-1383-4165
AD  - Section of Dermatology, Department of Clinical and Experimental Medicine, 
      University of Messina, 98125 Messina, Italy.
FAU - Boyko, Rostyslav
AU  - Boyko R
AD  - Postgraduate School of Allergy and Clinical Immunology, University of Modena and 
      Reggio Emilia, 41125 Modena, Italy.
FAU - Giorgi Rossi, Paolo
AU  - Giorgi Rossi P
AD  - Epidemiology Unit, Azienda Unita Sanitaria Locale-IRCCS di Reggio Emilia, 42122 
      Reggio Emilia, Italy.
FAU - Motolese, Alberico
AU  - Motolese A
AD  - Dermatology Unit, Azienda Unita Sanitaria Locale-IRCCS di Reggio Emilia, 42122 
      Reggio Emilia, Italy.
LA  - eng
PT  - Journal Article
DEP - 20220712
PL  - Switzerland
TA  - Vaccines (Basel)
JT  - Vaccines
JID - 101629355
PMC - PMC9324067
OTO - NOTNLM
OT  - COVID-19 vaccine
OT  - adverse events
OT  - allergy
OT  - risk stratification
COIS- The authors declare no conflict of interest.
EDAT- 2022/07/28 06:00
MHDA- 2022/07/28 06:01
PMCR- 2022/07/12
CRDT- 2022/07/27 01:43
PHST- 2022/05/12 00:00 [received]
PHST- 2022/07/11 00:00 [revised]
PHST- 2022/07/11 00:00 [accepted]
PHST- 2022/07/27 01:43 [entrez]
PHST- 2022/07/28 06:00 [pubmed]
PHST- 2022/07/28 06:01 [medline]
PHST- 2022/07/12 00:00 [pmc-release]
AID - vaccines10071111 [pii]
AID - vaccines-10-01111 [pii]
AID - 10.3390/vaccines10071111 [doi]
PST - epublish
SO  - Vaccines (Basel). 2022 Jul 12;10(7):1111. doi: 10.3390/vaccines10071111.