PMID- 3589182
OWN - NLM
STAT- MEDLINE
DCOM- 19870717
LR  - 20180216
IS  - 0025-7931 (Print)
IS  - 0025-7931 (Linking)
VI  - 51
IP  - 2
DP  - 1987
TI  - Unchanged bronchial reactivity after killed influenza virus vaccine in adult 
      asthmatics.
PG  - 98-104
AB  - Polyvalent killed influenza virus vaccine or saline was administered 
      subcutaneously to 27 asthmatics to investigate the effect of influenza vaccine on 
      respiratory function and on airway responsiveness to inhaled histamine. The 
      patients were adults with mild to moderate asthma. Airway resistance (Raw) and 
      intrathoracic gas volume (ITGV) were measured immediately before and 2, 3 and 21 
      days after vaccine or saline injection. Raw and ITGV values were used to 
      calculate specific airway conductance (SGaw). Bronchial reactivity was expressed 
      as the provocative dose of histamine diphosphate producing a decrease of 40% in 
      SGaw (PD40). Fourteen (87%) of 16 asthmatics who received killed virus vaccine 
      displayed a significant rise in serum antibody level as measured by single radial 
      haemolysis in gel test. No significant alterations in mean Raw, ITGV and SGaw 
      values were observed after viral vaccination. The median PD40 values for 
      histamine also remained unchanged. However, an increased bronchial reactivity was 
      observed in some patients after administration of virus vaccine or saline. 
      Subclinical natural infection or allergen exposure cannot be excluded as possible 
      causes of the increased airway reactivity in these patients. The side-effects of 
      vaccination were minimal and no more harmful than those produced by saline 
      injection. We conclude that the killed influenza virus vaccine used is effective 
      in boosting serum antibody levels and is suitable for adult asthmatics when 
      prophylactic immunisation is indicated.
FAU - Kava, T
AU  - Kava T
FAU - Lindqvist, A
AU  - Lindqvist A
FAU - Karjalainen, J
AU  - Karjalainen J
FAU - Laitinen, L A
AU  - Laitinen LA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Respiration
JT  - Respiration; international review of thoracic diseases
JID - 0137356
RN  - 0 (Influenza Vaccines)
RN  - 820484N8I3 (Histamine)
SB  - IM
MH  - Adult
MH  - *Airway Resistance
MH  - Asthma/*physiopathology
MH  - Bronchial Provocation Tests
MH  - Female
MH  - Histamine
MH  - Humans
MH  - Influenza Vaccines/*pharmacology
MH  - Male
MH  - Middle Aged
EDAT- 1987/01/01 00:00
MHDA- 1987/01/01 00:01
CRDT- 1987/01/01 00:00
PHST- 1987/01/01 00:00 [pubmed]
PHST- 1987/01/01 00:01 [medline]
PHST- 1987/01/01 00:00 [entrez]
AID - 10.1159/000195173 [doi]
PST - ppublish
SO  - Respiration. 1987;51(2):98-104. doi: 10.1159/000195173.