PMID- 35892420
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230308
IS  - 2076-3425 (Print)
IS  - 2076-3425 (Electronic)
IS  - 2076-3425 (Linking)
VI  - 12
IP  - 8
DP  - 2022 Jul 25
TI  - Retinal Thickness Correlates with Cerebral Hemodynamic Changes in Patients with 
      Carotid Artery Stenosis.
LID - 10.3390/brainsci12080979 [doi]
LID - 979
AB  - Background: We aimed to assess the retinal structural and choroidal changes in 
      carotid artery stenosis (CAS) patients and their association with cerebral 
      hemodynamic changes. Asymptomatic and symptomatic patients with unilateral CAS 
      were enrolled in our study. Material and methods: Swept-source optical coherence 
      tomography (SS-OCT) was used to image the retinal nerve fiber layer (RNFL), 
      ganglion cell-inner plexiform layer (GCIPL), while SS-OCT angiography (SS-OCTA) 
      was used to image and measure the choroidal vascular volume (CVV) and choroidal 
      vascular index (CVI). Computed Tomography Perfusion (CTP) was used to assess the 
      cerebral perfusion parameters; relative perfusion (r) was calculated as the ratio 
      of the value on the contralateral side to that on the ipsilateral side. Results: 
      Compared with contralateral eyes, ipsilateral eyes showed significantly thinner 
      RNFL (p < 0.001), GCIPL (p = 0.013) and CVV (p = 0.001). Relative cerebral blood 
      volume (rCBV) showed a significant correlation with RNFL (p < 0.001), GCIPL (p < 
      0.001) and CVI (p = 0.027), while the relative permeability surface (rPS) 
      correlated with RNFL (p < 0.001) and GCIPL (p < 0.001). Conclusions: Our report 
      suggests that retinal and choroidal changes have the potential to detect 
      hemodynamic changes in CAS patients and could predict the risk of stroke.
FAU - Kwapong, William Robert
AU  - Kwapong WR
AUID- ORCID: 0000-0001-9633-4694
AD  - Neurology Department, West China Hospital of Sichuan University, No. 37 Guo Xue 
      Xiang, Chengdu 610041, China.
FAU - Liu, Junfeng
AU  - Liu J
AD  - Neurology Department, West China Hospital of Sichuan University, No. 37 Guo Xue 
      Xiang, Chengdu 610041, China.
FAU - Wan, Jincheng
AU  - Wan J
AD  - Neurology Department, West China Hospital of Sichuan University, No. 37 Guo Xue 
      Xiang, Chengdu 610041, China.
FAU - Tao, Wendan
AU  - Tao W
AD  - Neurology Department, West China Hospital of Sichuan University, No. 37 Guo Xue 
      Xiang, Chengdu 610041, China.
FAU - Ye, Chen
AU  - Ye C
AUID- ORCID: 0000-0003-2969-5486
AD  - Neurology Department, West China Hospital of Sichuan University, No. 37 Guo Xue 
      Xiang, Chengdu 610041, China.
FAU - Wu, Bo
AU  - Wu B
AD  - Neurology Department, West China Hospital of Sichuan University, No. 37 Guo Xue 
      Xiang, Chengdu 610041, China.
LA  - eng
GR  - 81901199; 81601022/National Natural Science Foundation of China/
GR  - ZYGD18009/1.3.5 Project for Disciplines of excellence, West China Hospital, 
      Sichuan University/
PT  - Journal Article
DEP - 20220725
PL  - Switzerland
TA  - Brain Sci
JT  - Brain sciences
JID - 101598646
PMC - PMC9331379
OTO - NOTNLM
OT  - carotid artery stenosis
OT  - cerebral hemodynamics
OT  - choroid
OT  - computed tomography perfusion
OT  - retinal thickness
COIS- The authors declare no conflict of interest.
EDAT- 2022/07/28 06:00
MHDA- 2022/07/28 06:01
PMCR- 2022/07/25
CRDT- 2022/07/27 04:53
PHST- 2022/06/22 00:00 [received]
PHST- 2022/07/11 00:00 [revised]
PHST- 2022/07/22 00:00 [accepted]
PHST- 2022/07/27 04:53 [entrez]
PHST- 2022/07/28 06:00 [pubmed]
PHST- 2022/07/28 06:01 [medline]
PHST- 2022/07/25 00:00 [pmc-release]
AID - brainsci12080979 [pii]
AID - brainsci-12-00979 [pii]
AID - 10.3390/brainsci12080979 [doi]
PST - epublish
SO  - Brain Sci. 2022 Jul 25;12(8):979. doi: 10.3390/brainsci12080979.