PMID- 35892629
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220824
IS  - 2076-3921 (Print)
IS  - 2076-3921 (Electronic)
IS  - 2076-3921 (Linking)
VI  - 11
IP  - 8
DP  - 2022 Jul 22
TI  - Normal and Pathological NRF2 Signalling in the Central Nervous System.
LID - 10.3390/antiox11081426 [doi]
LID - 1426
AB  - The nuclear factor erythroid 2-related factor 2 (NRF2) was originally described 
      as a master regulator of antioxidant cellular response, but in the time since, 
      numerous important biological functions linked to cell survival, cellular 
      detoxification, metabolism, autophagy, proteostasis, inflammation, immunity, and 
      differentiation have been attributed to this pleiotropic transcription factor 
      that regulates hundreds of genes. After 40 years of in-depth research and key 
      discoveries, NRF2 is now at the center of a vast regulatory network, revealing 
      NRF2 signalling as increasingly complex. It is widely recognized that reactive 
      oxygen species (ROS) play a key role in human physiological and pathological 
      processes such as ageing, obesity, diabetes, cancer, and neurodegenerative 
      diseases. The high oxygen consumption associated with high levels of free iron 
      and oxidizable unsaturated lipids make the brain particularly vulnerable to 
      oxidative stress. A good stability of NRF2 activity is thus crucial to maintain 
      the redox balance and therefore brain homeostasis. In this review, we have 
      gathered recent data about the contribution of the NRF2 pathway in the healthy 
      brain as well as during metabolic diseases, cancer, ageing, and ageing-related 
      neurodegenerative diseases. We also discuss promising therapeutic strategies and 
      the need for better understanding of cell-type-specific functions of NRF2 in 
      these different fields.
FAU - Heurtaux, Tony
AU  - Heurtaux T
AUID- ORCID: 0000-0002-1709-5312
AD  - Department of Life Sciences and Medicine (DLSM), University of Luxembourg, 4367 
      Belvaux, Luxembourg.
AD  - Luxembourg Center of Neuropathology (LCNP), 3555 Dudelange, Luxembourg.
FAU - Bouvier, David S
AU  - Bouvier DS
AD  - Luxembourg Center of Neuropathology (LCNP), 3555 Dudelange, Luxembourg.
AD  - National Center of Pathology (NCP), Laboratoire National de Sante (LNS), 3555 
      Dudelange, Luxembourg.
AD  - Luxembourg Centre of Systems Biomedicine (LCSB), University of Luxembourg, 4367 
      Belvaux, Luxembourg.
FAU - Benani, Alexandre
AU  - Benani A
AD  - Centre des Sciences du Gout et de l'Alimentation, AgroSup Dijon, CNRS, INRAE, 
      Universite Bourgogne Franche-Comte, 21000 Dijon, France.
FAU - Helgueta Romero, Sergio
AU  - Helgueta Romero S
AD  - Department of Life Sciences and Medicine (DLSM), University of Luxembourg, 4367 
      Belvaux, Luxembourg.
AD  - Luxembourg Center of Neuropathology (LCNP), 3555 Dudelange, Luxembourg.
FAU - Frauenknecht, Katrin B M
AU  - Frauenknecht KBM
AD  - Luxembourg Center of Neuropathology (LCNP), 3555 Dudelange, Luxembourg.
AD  - National Center of Pathology (NCP), Laboratoire National de Sante (LNS), 3555 
      Dudelange, Luxembourg.
FAU - Mittelbronn, Michel
AU  - Mittelbronn M
AD  - Department of Life Sciences and Medicine (DLSM), University of Luxembourg, 4367 
      Belvaux, Luxembourg.
AD  - Luxembourg Center of Neuropathology (LCNP), 3555 Dudelange, Luxembourg.
AD  - National Center of Pathology (NCP), Laboratoire National de Sante (LNS), 3555 
      Dudelange, Luxembourg.
AD  - Luxembourg Centre of Systems Biomedicine (LCSB), University of Luxembourg, 4367 
      Belvaux, Luxembourg.
AD  - Luxembourg Institute of Health (LIH), 1526 Luxembourg, Luxembourg.
FAU - Sinkkonen, Lasse
AU  - Sinkkonen L
AD  - Department of Life Sciences and Medicine (DLSM), University of Luxembourg, 4367 
      Belvaux, Luxembourg.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20220722
PL  - Switzerland
TA  - Antioxidants (Basel)
JT  - Antioxidants (Basel, Switzerland)
JID - 101668981
PMC - PMC9394413
OTO - NOTNLM
OT  - NRF2
OT  - ageing
OT  - cancer
OT  - diet
OT  - epigenetic regulation
OT  - glial cells
OT  - neurodegeneration
OT  - reactive oxygen species
COIS- The authors declare no competing financial or non-financial interests.
EDAT- 2022/07/28 06:00
MHDA- 2022/07/28 06:01
PMCR- 2022/07/22
CRDT- 2022/07/27 04:54
PHST- 2022/05/31 00:00 [received]
PHST- 2022/07/18 00:00 [revised]
PHST- 2022/07/19 00:00 [accepted]
PHST- 2022/07/27 04:54 [entrez]
PHST- 2022/07/28 06:00 [pubmed]
PHST- 2022/07/28 06:01 [medline]
PHST- 2022/07/22 00:00 [pmc-release]
AID - antiox11081426 [pii]
AID - antioxidants-11-01426 [pii]
AID - 10.3390/antiox11081426 [doi]
PST - epublish
SO  - Antioxidants (Basel). 2022 Jul 22;11(8):1426. doi: 10.3390/antiox11081426.