PMID- 35893348
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220731
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 11
IP  - 15
DP  - 2022 Jul 22
TI  - Does Aerobic plus Machine-Assisted Resistance Training Improve Vascular Function 
      in Type 2 Diabetes? A Systematic Review and Meta-Analysis of Randomized 
      Controlled Trials with Trial Sequential Analysis.
LID - 10.3390/jcm11154257 [doi]
LID - 4257
AB  - Type 2 diabetes mellitus (T2DM) is a chronic disease characterized by 
      hyperglycemia, insulin resistance, and pancreatic B cell dysfunction. 
      Hyperglycemia can cause several complications, including nephrological, 
      neurological, ophthalmological, and vascular complications. Many modalities, such 
      as medication, physical therapies, and exercise, are developed against vascular 
      disorders. Among all exercise forms, aerobic plus machine-assisted resistance 
      training is widely applied. However, whether this intervention can significantly 
      improve vascular conditions remains controversial. In this study, an electronic 
      search was processed for the Pubmed, Embase, and Cochrane libraries for 
      randomized controlled trials (RCTs) comparing the efficacy of aerobic plus 
      machine-assisted resistance training with no exercise (control) on patients with 
      T2DM. Pulse wave velocity (PWV), the index of arterial stiffness, was chosen as 
      primary outcome. The reliability of the pooled outcome was tested by trial 
      sequential analysis (TSA). Secondary outcomes included systolic blood pressure 
      (SBP) and hemoglobin A1c (HbA1c). Finally, five RCTs with a total of 328 patients 
      were included. Compared with control, aerobic plus machine-assisted resistance 
      training failed to provide significant improvement on PWV (MD -0.54 m/s, 95% CI 
      [-1.69, 0.60], p = 0.35). On the other hand, TSA indicated that this results till 
      needs more verifications. Additionally, this training protocol did not 
      significantly decrease SBP (MD -1.05 mmHg, 95% CI [-3.71, 1.61], p = 0.44), but 
      significantly reduced the level of HbA1c (MD -0.55%, 95% CI [-0.88, -0.22], p = 
      0.001). In conclusion, this meta-analysis failed to detect a direct benefit of 
      aerobic plus machine-assisted resistance training on vascular condition in T2DM 
      population. Yet the improvement in HbA1c implied a potential of this training 
      method in mitigating vascular damage. More studies are needed to verify the 
      benefit.
FAU - Guo, Xianshan
AU  - Guo X
AD  - Department of Endocrinology, Xinxiang Central Hospital/The Fourth Clinical 
      College of Xinxiang Medical University, Xinxiang 453000, China.
FAU - Guo, Shizhe
AU  - Guo S
AD  - Department of Endocrinology, Yangpu Hospital, School of Medicine, Tongji 
      University, No. 450 Tengyue Road, Yangpu District, Shanghai 200090, China.
FAU - Zhang, Hongmei
AU  - Zhang H
AD  - Yangpu Mental Health Center, No. 585 Jungong Road, Yangpu District, Shanghai 
      900093, China.
FAU - Li, Zhen
AU  - Li Z
AD  - Department of General Surgery, Yangpu Hospital, School of Medicine, Tongji 
      University, No. 450 Tengyue Road, Yangpu District, Shanghai 200090, China.
LA  - eng
GR  - 2020-14/Chenguang Plan of Yangpu Hospital, Tongji University/
GR  - [2019] No. 108/Fund for psychosomatic medicine, key discipline of district level 
      of Shanghai Yangpu District mental health center/
PT  - Journal Article
PT  - Review
DEP - 20220722
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC9331013
OTO - NOTNLM
OT  - aerobic training
OT  - diabetes mellitus
OT  - meta-analysis
OT  - resistance training
OT  - vascular function
COIS- The authors declare no conflict of interest.
EDAT- 2022/07/28 06:00
MHDA- 2022/07/28 06:01
PMCR- 2022/07/22
CRDT- 2022/07/27 04:59
PHST- 2022/05/17 00:00 [received]
PHST- 2022/06/13 00:00 [revised]
PHST- 2022/07/04 00:00 [accepted]
PHST- 2022/07/27 04:59 [entrez]
PHST- 2022/07/28 06:00 [pubmed]
PHST- 2022/07/28 06:01 [medline]
PHST- 2022/07/22 00:00 [pmc-release]
AID - jcm11154257 [pii]
AID - jcm-11-04257 [pii]
AID - 10.3390/jcm11154257 [doi]
PST - epublish
SO  - J Clin Med. 2022 Jul 22;11(15):4257. doi: 10.3390/jcm11154257.