PMID- 35894768
OWN - NLM
STAT- MEDLINE
DCOM- 20221122
LR  - 20221205
IS  - 1542-474X (Electronic)
IS  - 1082-720X (Print)
IS  - 1082-720X (Linking)
VI  - 27
IP  - 6
DP  - 2022 Nov
TI  - The effects of aerobic exercise combined with resistance training on inflammatory 
      factors and heart rate variability in middle-aged and elderly women with type 2 
      diabetes mellitus.
PG  - e12996
LID - 10.1111/anec.12996 [doi]
LID - e12996
AB  - OBJECTIVE: This study investigated the effects of aerobic exercise combined with 
      resistance training on serum inflammatory factors and heart rate variability 
      (HRV) in women with type 2 diabetes mellitus (T2DM). METHODS: A total of 30 
      patients with diabetic cardiovascular autonomic neuropathy (DCAN) were randomly 
      divided into a control group (n = 15) and an exercise group (n = 15). The control 
      group was treated with routine hypoglycemic drugs, while the exercise group was 
      treated with routine hypoglycemic drugs + resistance training (AE + RT). The 
      levels of fasting plasma glucose (FBG), two-hour plasma glucose (2hPG), serum 
      inflammatory factors C-reactive protein (CRP), interleukin-6 (IL-6) and tumor 
      necrosis factor alpha (TNF-alpha) were measured before and after the intervention. 
      The HRV was evaluated by 24-h ambulatory electrocardiogram. RESULTS: After the 
      intervention, the levels of FBG, 2hPG, serum inflammatory factors, IL-6 and TNF-alpha 
      in the exercise group were significantly lower than those in the control group 
      (p < .05) with no significant differences in serum CRP (p > .05). After the 
      intervention, the HRV time domain and frequency domain indexes in the two groups 
      were significantly improved compared with those before the exercise experiment 
      (p < .01) and with no significant difference in (lnlf) (p > .05). The time-domain 
      indexes, i.e., SDNN and RMSSD, as well as the frequency domain index, i.e., 
      (lnhf), were significantly higher in the exercise group than in the control 
      group, whereas lnlf/lnhf were significantly lower than those in the control group 
      (p < .05). CONCLUSIONS: Compared with routine hypoglycemic drug therapy, 
      combining aerobic exercise and resistance training helped to reduce the level of 
      blood glucose and serum inflammatory factors in T2DM patients with DCAN, and 
      improved autonomic nerve function.
CI  - (c) 2022 The Authors. Annals of Noninvasive Electrocardiology published by Wiley 
      Periodicals LLC.
FAU - Su, Xiaoyun
AU  - Su X
AD  - Department of Nursing, Fenyang College Shanxi Medical University, Fenyang, China.
FAU - He, Jiping
AU  - He J
AUID- ORCID: 0000-0002-4472-2545
AD  - Department of Anatomy, Fenyang College Shanxi Medical University, Fenyang, China.
FAU - Cui, Jianmei
AU  - Cui J
AD  - Department of Sports, North University of China, Taiyuan, China.
FAU - Li, Hongmei
AU  - Li H
AD  - Department of Nursing, Fenyang College Shanxi Medical University, Fenyang, China.
FAU - Men, Jie
AU  - Men J
AD  - Department of Sports, Fenyang College Shanxi Medical University, Fenyang, China.
LA  - eng
GR  - GH-19211/Shanxi Province education science "13th five-year plan" project/
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20220727
PL  - United States
TA  - Ann Noninvasive Electrocardiol
JT  - Annals of noninvasive electrocardiology : the official journal of the 
      International Society for Holter and Noninvasive Electrocardiology, Inc
JID - 9607443
RN  - 0 (Blood Glucose)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (Interleukin-6)
RN  - 0 (Hypoglycemic Agents)
SB  - IM
MH  - Middle Aged
MH  - Aged
MH  - Humans
MH  - Female
MH  - Heart Rate/physiology
MH  - *Diabetes Mellitus, Type 2/complications/therapy
MH  - *Resistance Training
MH  - Blood Glucose/metabolism
MH  - Tumor Necrosis Factor-alpha
MH  - Interleukin-6
MH  - Exercise Therapy
MH  - Electrocardiography
MH  - Exercise/physiology
MH  - Hypoglycemic Agents/therapeutic use
PMC - PMC9674784
OTO - NOTNLM
OT  - aerobic exercise and resistance exercise
OT  - blood glucose
OT  - heart rate variability
OT  - inflammatory cytokines
OT  - type 2 diabetes
COIS- None of the authors had any personal, financial, commercial, or academic 
      conflicts of interest.
EDAT- 2022/07/28 06:00
MHDA- 2022/11/23 06:00
PMCR- 2022/07/27
CRDT- 2022/07/27 09:54
PHST- 2022/06/17 00:00 [revised]
PHST- 2022/05/25 00:00 [received]
PHST- 2022/07/03 00:00 [accepted]
PHST- 2022/07/28 06:00 [pubmed]
PHST- 2022/11/23 06:00 [medline]
PHST- 2022/07/27 09:54 [entrez]
PHST- 2022/07/27 00:00 [pmc-release]
AID - ANEC12996 [pii]
AID - 10.1111/anec.12996 [doi]
PST - ppublish
SO  - Ann Noninvasive Electrocardiol. 2022 Nov;27(6):e12996. doi: 10.1111/anec.12996. 
      Epub 2022 Jul 27.