PMID- 35895219
OWN - NLM
STAT- MEDLINE
DCOM- 20220822
LR  - 20220830
IS  - 2092-9293 (Electronic)
IS  - 1976-9571 (Linking)
VI  - 44
IP  - 9
DP  - 2022 Sep
TI  - Genetic polymorphism of HLA-DRA and alcohol consumption affect hepatitis 
      development in the Korean population.
PG  - 1109-1116
LID - 10.1007/s13258-022-01286-1 [doi]
AB  - BACKGROUND: Hepatitis is an inflammation of the liver that has several potential 
      causes; however, the genetic association has recently begun to be studied. 
      OBJECTIVES: Human leukocyte antigen (HLA) is an essential component of the immune 
      response, and in this study, we conducted a correlation analysis to determine 
      whether genetic polymorphisms of HLA and drinking habits affect hepatitis 
      development. METHODS: Genetic polymorphisms of HLA were investigated using Korean 
      genomic and epidemiological data. A gene association study was performed using 
      PLINK version 1.07. Other statistical analyses and multivariate logistic 
      regression analyses were performed using PASW Statistics version 18.0. RESULTS: 
      Thirteen single nucleotide polymorphisms (SNPs) in HLA-DRA showed significant 
      statistical correlations with hepatitis. In particular, rs9268645 showed the 
      highest statistical association with hepatitis (P = 3.97 x 10(-5), odds ratio 
      [OR] = 0.72, 95% confidence interval [CI] = 0.61-0.84). In multivariate logistic 
      regression analysis, when considering only genetic factors, the A allele of 
      rs9268644 showed a reduced hepatitis OR of approximately 0.52-fold. However, the 
      group carrying the minor A allele (AA + AC) with alcohol consumption had an 
      approximately 1.58-fold OR of hepatitis compared to that of the group carrying 
      the same allele with no alcohol consumption. This implies that the A allele of 
      rs9268644 has a protective effect on hepatitis by genetic factors and shows 
      sensitivity to alcohol. CONCLUSIONS: Our results showed that hepatitis is 
      influenced by both genetic and external factors (drinking habits), which can 
      provide new guidelines for the prevention or treatment of hepatitis.
CI  - (c) 2022. The Author(s) under exclusive licence to The Genetics Society of Korea.
FAU - Hong, Mijin
AU  - Hong M
AD  - Department of Biomedical Laboratory Science, College of Life and Health Sciences, 
      Hoseo University, Asan, Chungnam, 31499, South Korea.
FAU - Jung, Jaemee
AU  - Jung J
AD  - Department of Biomedical Laboratory Science, College of Life and Health Sciences, 
      Hoseo University, Asan, Chungnam, 31499, South Korea.
FAU - Jin, Hyun-Seok
AU  - Jin HS
AUID- ORCID: 0000-0002-3673-9806
AD  - Department of Biomedical Laboratory Science, College of Life and Health Sciences, 
      Hoseo University, Asan, Chungnam, 31499, South Korea. jinhs@hoseo.edu.
FAU - Hwang, Dahyun
AU  - Hwang D
AUID- ORCID: 0000-0003-1605-8509
AD  - Department of Biomedical Laboratory Science, College of Life and Health Sciences, 
      Hoseo University, Asan, Chungnam, 31499, South Korea. hdh@hoseo.edu.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220727
PL  - Korea (South)
TA  - Genes Genomics
JT  - Genes & genomics
JID - 101481027
RN  - 0 (HLA-DR alpha-Chains)
SB  - IM
MH  - Case-Control Studies
MH  - HLA-DR alpha-Chains/*genetics
MH  - *Hepatitis/genetics
MH  - Humans
MH  - *Polymorphism, Single Nucleotide
MH  - Republic of Korea
OTO - NOTNLM
OT  - Alcohol consumption
OT  - HLA-DRA
OT  - Hepatitis
OT  - Korean population
OT  - Single nucleotide polymorphism
EDAT- 2022/07/28 06:00
MHDA- 2022/08/23 06:00
CRDT- 2022/07/27 11:58
PHST- 2021/12/25 00:00 [received]
PHST- 2022/07/10 00:00 [accepted]
PHST- 2022/07/28 06:00 [pubmed]
PHST- 2022/08/23 06:00 [medline]
PHST- 2022/07/27 11:58 [entrez]
AID - 10.1007/s13258-022-01286-1 [pii]
AID - 10.1007/s13258-022-01286-1 [doi]
PST - ppublish
SO  - Genes Genomics. 2022 Sep;44(9):1109-1116. doi: 10.1007/s13258-022-01286-1. Epub 
      2022 Jul 27.