PMID- 35895636
OWN - NLM
STAT- MEDLINE
DCOM- 20221103
LR  - 20221103
IS  - 1873-474X (Electronic)
IS  - 0736-5748 (Linking)
VI  - 82
IP  - 7
DP  - 2022 Nov
TI  - The study of functional connectivity of attention cognitive impairment in 
      children with nocturnal enuresis.
PG  - 646-653
LID - 10.1002/jdn.10218 [doi]
AB  - We aimed to explore the brain functional connectivity mechanism of attention 
      cognitive impairment in children with nocturnal enuresis (NE). Children with NE 
      often show attention cognitive deficit, but its brain mechanism remains unclear. 
      Most previous studies have only focused on a single brain region, without 
      involving the association among brain regions. In this study, 26 NE and 26 normal 
      children were selected. Functional magnetic resonance imaging (fMRI) and 
      integrated visual and auditory continuous performance test (IVA-CPT) were 
      performed. The 12 key brain regions of the dorsal attention network (DAN), 
      default mode network (DMN) and ventral attention network (VAN) were selected as 
      areas of interest, and 66 groups of functional connectivity (FC) were analysed 
      among these 12 brain regions. The correlation between FC and IVA-CPT in the two 
      groups was analysed. The FC values showed that the groups with significant 
      differences between NE and normal children were lFEF-aMPFC, rFEF-lIFG, rFEF-rIPS 
      and lAG-VFC (P < 0.05), and the FC value of lAG-VFC was positively correlated 
      with the Full-Scale Attention Quotient (FAQ). Our results showed that attention 
      deficit in children with NE was associated with all three networks and was 
      relative to the FC among the three attention networks. DAN was the brain network 
      most related to attention cognition in children with NE, and most of the brain 
      regions with abnormal connectivity in NE were related to the prefrontal lobe. The 
      lAG was also an important brain region in attention impairment in NE.
CI  - (c) 2022 International Society for Developmental Neuroscience.
FAU - Jiang, Kaihua
AU  - Jiang K
AUID- ORCID: 0000-0001-7125-5535
AD  - Department of Nephrology and Immunology, Children's Hospital of Soochow 
      University, Suzhou, China.
AD  - Institute of Pediatric Research, Children's Hospital of Soochow University, 
      Suzhou, China.
AD  - Department of Pediatrics, Affiliated Changzhou Children's Hospital of Nantong 
      University, Changzhou, China.
FAU - Liu, Liangqing
AU  - Liu L
AD  - Department of Radiology, Affiliated WuJin Hospital of Jiangsu University, 
      Changzhou, China.
FAU - Pan, Chenzhu
AU  - Pan C
AD  - Department of Pediatrics, Affiliated Changzhou Children's Hospital of Nantong 
      University, Changzhou, China.
FAU - Ge, Yawen
AU  - Ge Y
AD  - Department of Pediatrics, Affiliated Changzhou Children's Hospital of Nantong 
      University, Changzhou, China.
FAU - Zheng, Aibin
AU  - Zheng A
AD  - Department of Pediatrics, Affiliated Changzhou Children's Hospital of Nantong 
      University, Changzhou, China.
FAU - Li, Yamin
AU  - Li Y
AD  - Department of Pediatrics, Affiliated Changzhou Children's Hospital of Nantong 
      University, Changzhou, China.
FAU - Li, Yanhong
AU  - Li Y
AD  - Department of Nephrology and Immunology, Children's Hospital of Soochow 
      University, Suzhou, China.
AD  - Institute of Pediatric Research, Children's Hospital of Soochow University, 
      Suzhou, China.
LA  - eng
GR  - ZD202122/Major science and technology projects of Changzhou Commission of Health/
GR  - H2019005/Medical Research Projects of Jiangsu Commission of Health/
PT  - Journal Article
DEP - 20220809
PL  - United States
TA  - Int J Dev Neurosci
JT  - International journal of developmental neuroscience : the official journal of the 
      International Society for Developmental Neuroscience
JID - 8401784
SB  - IM
MH  - Child
MH  - Humans
MH  - Brain Mapping
MH  - Nerve Net
MH  - *Nocturnal Enuresis
MH  - *Cognitive Dysfunction
MH  - Magnetic Resonance Imaging/methods
MH  - Brain
OTO - NOTNLM
OT  - attention
OT  - functional connectivity
OT  - nocturnal enuresis
EDAT- 2022/07/28 06:00
MHDA- 2022/11/04 06:00
CRDT- 2022/07/27 13:34
PHST- 2022/07/19 00:00 [revised]
PHST- 2022/06/14 00:00 [received]
PHST- 2022/07/20 00:00 [accepted]
PHST- 2022/07/28 06:00 [pubmed]
PHST- 2022/11/04 06:00 [medline]
PHST- 2022/07/27 13:34 [entrez]
AID - 10.1002/jdn.10218 [doi]
PST - ppublish
SO  - Int J Dev Neurosci. 2022 Nov;82(7):646-653. doi: 10.1002/jdn.10218. Epub 2022 Aug 
      9.