PMID- 35896125
OWN - NLM
STAT- MEDLINE
DCOM- 20221115
LR  - 20230124
IS  - 1538-2990 (Electronic)
IS  - 0002-9629 (Linking)
VI  - 364
IP  - 6
DP  - 2022 Dec
TI  - Proton pump inhibitor use and its effect on vitamin B12 and homocysteine levels 
      among men and women: A large cross-sectional study.
PG  - 746-751
LID - S0002-9629(22)00313-5 [pii]
LID - 10.1016/j.amjms.2022.07.006 [doi]
AB  - BACKGROUND: Previous studies have demonstrated an association between proton pump 
      inhibitors (PPI) use and vitamin B12 deficiency. However, data regarding PPI use 
      and elevated serum homocysteine level, an important marker of vitamin B12 
      deficiency, are scant. METHODS: Data were collected from medical records of 
      subjects examined at a screening center in Israel. Cross sectional analysis was 
      conducted on 25,953 subjects. Levels of vitamin B12 and homocysteine were 
      compared between subjects who consumed PPI medications and those who did not. 
      RESULTS: The mean age of the study population was 45 years and 33% were females. 
      Subjects who received PPI medications had a minor higher vitamin B12 levels (320 
      pmol/L vs 300 pmol/L, p=0.024). Levels of vitamin B12 remained higher in females 
      receiving PPI medications after performing a stratified analysis according to 
      subjects' gender. Homocysteine levels were higher in subjects receiving PPI 
      medications as compared to those who did not (12.0 mumol/L vs 11.6 0 mumol/L, 
      p<0.001). Levels remained higher in female subjects after performing a stratified 
      analysis according to subjects' sex. There was no statistically significant 
      difference in the prevalence of vitamin B12 deficiency (according to two cutoffs: 
      vitamin B12</=200 or </=140 pmol/L) as well as the prevalence of hyperhomocysteinemia 
      (defined as homocysteine >15.0 mumol/L) between the two groups. CONCLUSIONS: 
      According to our study, no association was found between PPI medication use and 
      vitamin B12 deficiency or hyperhomocysteinemia. Patients receiving PPI 
      medications had slightly higher levels of vitamin B12 and homocysteine, however 
      these differences were too small to have any clinical relevance.
CI  - Copyright (c) 2022 Southern Society for Clinical Investigation. Published by 
      Elsevier Inc. All rights reserved.
FAU - Lerman, Tsahi T
AU  - Lerman TT
AD  - Department of Internal Medicine F-Recanati, Rabin Medical Center, Beilinson 
      Hospital, Petah Tiqva, Israel; Sackler Faculty of Medicine, Tel Aviv University, 
      Ramat Aviv, Tel Aviv, Israel. Electronic address: tsahilerman@gmail.com.
FAU - Cohen, Eytan
AU  - Cohen E
AD  - Department of Internal Medicine F-Recanati, Rabin Medical Center, Beilinson 
      Hospital, Petah Tiqva, Israel; Sackler Faculty of Medicine, Tel Aviv University, 
      Ramat Aviv, Tel Aviv, Israel.
FAU - Sochat, Tzippy
AU  - Sochat T
AD  - Statistical Consulting Unit, Beilinson Hospital, Rabin Medical Center, Petah 
      Tikva, Israel.
FAU - Goldberg, Elad
AU  - Goldberg E
AD  - Department of Internal Medicine F-Recanati, Rabin Medical Center, Beilinson 
      Hospital, Petah Tiqva, Israel; Sackler Faculty of Medicine, Tel Aviv University, 
      Ramat Aviv, Tel Aviv, Israel.
FAU - Goldberg, Idan
AU  - Goldberg I
AD  - Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Tel Aviv, Israel; 
      Institute of Hematology, Davidoff Cancer Center, Rabin Medical Center, Petah 
      Tikva, Israel.
FAU - Krause, Ilan
AU  - Krause I
AD  - Department of Internal Medicine F-Recanati, Rabin Medical Center, Beilinson 
      Hospital, Petah Tiqva, Israel; Sackler Faculty of Medicine, Tel Aviv University, 
      Ramat Aviv, Tel Aviv, Israel.
LA  - eng
PT  - Journal Article
DEP - 20220724
PL  - United States
TA  - Am J Med Sci
JT  - The American journal of the medical sciences
JID - 0370506
RN  - P6YC3EG204 (Vitamin B 12)
RN  - 0 (Proton Pump Inhibitors)
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - 935E97BOY8 (Folic Acid)
SB  - IM
MH  - Male
MH  - Humans
MH  - Female
MH  - Middle Aged
MH  - Vitamin B 12
MH  - Cross-Sectional Studies
MH  - *Hyperhomocysteinemia/chemically induced/epidemiology
MH  - Proton Pump Inhibitors/adverse effects
MH  - *Vitamin B 12 Deficiency/chemically induced/epidemiology
MH  - Homocysteine
MH  - Folic Acid
OTO - NOTNLM
OT  - Homocysteine
OT  - Hyperhomocysteinemia
OT  - PPI, Proton pump inhibitor
OT  - Vitamin B12
COIS- Declaration of Competing Interest Nothing to declare.
EDAT- 2022/07/28 06:00
MHDA- 2022/11/16 06:00
CRDT- 2022/07/27 19:12
PHST- 2021/10/10 00:00 [received]
PHST- 2022/03/28 00:00 [revised]
PHST- 2022/07/18 00:00 [accepted]
PHST- 2022/07/28 06:00 [pubmed]
PHST- 2022/11/16 06:00 [medline]
PHST- 2022/07/27 19:12 [entrez]
AID - S0002-9629(22)00313-5 [pii]
AID - 10.1016/j.amjms.2022.07.006 [doi]
PST - ppublish
SO  - Am J Med Sci. 2022 Dec;364(6):746-751. doi: 10.1016/j.amjms.2022.07.006. Epub 
      2022 Jul 24.