PMID- 35897757
OWN - NLM
STAT- MEDLINE
DCOM- 20220729
LR  - 20220731
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 23
IP  - 15
DP  - 2022 Jul 25
TI  - Biomedical Polyurethanes for Anti-Cancer Drug Delivery Systems: A Brief, 
      Comprehensive Review.
LID - 10.3390/ijms23158181 [doi]
LID - 8181
AB  - With the intensive development of polymeric biomaterials in recent years, 
      research using drug delivery systems (DDSs) has become an essential strategy for 
      cancer therapy. Various DDSs are expected to have more advantages in 
      anti-neoplastic effects, including easy preparation, high pharmacology 
      efficiency, low toxicity, tumor-targeting ability, and high drug-controlled 
      release. Polyurethanes (PUs) are a very important kind of polymers widely used in 
      medicine, pharmacy, and biomaterial engineering. Biodegradable and 
      non-biodegradable PUs are a significant group of these biomaterials. PUs can be 
      synthesized by adequately selecting building blocks (a polyol, a di- or 
      multi-isocyanate, and a chain extender) with suitable physicochemical and 
      biological properties for applications in anti-cancer DDSs technology. Currently, 
      there are few comprehensive reports on a summary of polyurethane DDSs (PU-DDSs) 
      applied for tumor therapy. This study reviewed state-of-the-art PUs designed for 
      anti-cancer PU-DDSs. We studied successful applications and prospects for further 
      development of effective methods for obtaining PUs as biomaterials for oncology.
FAU - Sobczak, Marcin
AU  - Sobczak M
AUID- ORCID: 0000-0002-7362-8881
AD  - Department of Biomaterials Chemistry, Chair of Analytical Chemistry and 
      Biomaterials, Faculty of Pharmacy, Medical University of Warsaw, 1 Banacha St., 
      02-097 Warsaw, Poland.
AD  - Military Institute of Hygiene and Epidemiology, 4 Kozielska St., 01-163 Warsaw, 
      Poland.
FAU - Kedra, Karolina
AU  - Kedra K
AD  - Institute of Physical Chemistry, Polish Academy of Sciences, 44/52 Kasprzaka St., 
      01-224 Warsaw, Poland.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20220725
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Biocompatible Materials)
RN  - 0 (Polyurethanes)
SB  - IM
MH  - Biocompatible Materials/chemistry
MH  - Drug Delivery Systems
MH  - Humans
MH  - *Neoplasms/drug therapy
MH  - *Polyurethanes/chemistry
MH  - Suppuration
PMC - PMC9329922
OTO - NOTNLM
OT  - anti-cancer drug delivery systems
OT  - biodegradable polyurethanes
OT  - biomaterials
OT  - biomedical polyurethanes
OT  - drug delivery systems
OT  - polyurethane chemistry
COIS- The authors declare no conflict of interest. The authors declare no competing 
      financial interest or personal relationships that could have appeared to 
      influence the work reported in this paper.
EDAT- 2022/07/29 06:00
MHDA- 2022/07/30 06:00
PMCR- 2022/07/25
CRDT- 2022/07/28 01:09
PHST- 2022/07/01 00:00 [received]
PHST- 2022/07/20 00:00 [revised]
PHST- 2022/07/22 00:00 [accepted]
PHST- 2022/07/28 01:09 [entrez]
PHST- 2022/07/29 06:00 [pubmed]
PHST- 2022/07/30 06:00 [medline]
PHST- 2022/07/25 00:00 [pmc-release]
AID - ijms23158181 [pii]
AID - ijms-23-08181 [pii]
AID - 10.3390/ijms23158181 [doi]
PST - epublish
SO  - Int J Mol Sci. 2022 Jul 25;23(15):8181. doi: 10.3390/ijms23158181.