PMID- 35898457
OWN - NLM
STAT- MEDLINE
DCOM- 20220729
LR  - 20220729
IS  - 1664-2392 (Print)
IS  - 1664-2392 (Electronic)
IS  - 1664-2392 (Linking)
VI  - 13
DP  - 2022
TI  - Bioinformatics Analysis Identifies Potential Ferroptosis Key Gene in Type 2 
      Diabetic Islet Dysfunction.
PG  - 904312
LID - 10.3389/fendo.2022.904312 [doi]
LID - 904312
AB  - BACKGROUND: Islet beta cells dysfunction (IBCD) is a cortical component in 
      pathogenesis of type 2 diabetic mellitus (T2DM). However, the relationship of 
      ferroptosis and IBCD remains unknown. This study was aimed to screen potential 
      ferroptosis key genes to reveal latent physiological and pathological process of 
      IBCD in T2DM. METHODS: Firstly, T2DM key genes were screened by combining with 
      differentially expressed genes (DEGs) analysis and WGCNA. Then, 
      ferroptosis-related genes (FRGs) in IBCD of T2DM were identified by taking the 
      intersection between T2DM key genes and FRGs. Finally, T2DM-FRGs were validated 
      in another T2DM dataset as well as islet single-cell RNA sequencing dataset and 
      the miRNA regulated T2DM-FRG was predicted by using four miRNA databases. 
      RESULTS: 89 T2DM key genes were identified between DEGs and WGCNA. Then, 3 
      T2DM-FRGs were screened by taking the intersection of T2DM key genes and FRGs, 
      namely ITGA6, MGST1 and ENO2. At last, MGST1 were validated as the T2DM-FRG in 
      another T2DM islet issues dataset and islet single-cell RNA sequencing dataset. 
      CONCLUSION: MGST1 may be the potential ferroptosis key gene of IBCD in T2DM.
CI  - Copyright (c) 2022 Ye, Wang, Wei, Wang, Zhang and Wang.
FAU - Ye, Haowen
AU  - Ye H
AD  - Department of Endocrinology and Metabolism, First Affiliated Hospital of Jinan 
      University, Guangzhou, China.
FAU - Wang, Ruxin
AU  - Wang R
AD  - Department of Endocrinology and Metabolism, First Affiliated Hospital of Jinan 
      University, Guangzhou, China.
FAU - Wei, Jinjing
AU  - Wei J
AD  - Department of Endocrinology and Metabolism, First Affiliated Hospital of Jinan 
      University, Guangzhou, China.
FAU - Wang, Ying
AU  - Wang Y
AD  - Department of Endocrinology and Metabolism, First Affiliated Hospital of Jinan 
      University, Guangzhou, China.
FAU - Zhang, Xiaofang
AU  - Zhang X
AD  - Clinical Experimental Center, First Affiliated Hospital of Jinan University, 
      Guangzhou, China.
FAU - Wang, Lihong
AU  - Wang L
AD  - Department of Endocrinology and Metabolism, First Affiliated Hospital of Jinan 
      University, Guangzhou, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220711
PL  - Switzerland
TA  - Front Endocrinol (Lausanne)
JT  - Frontiers in endocrinology
JID - 101555782
RN  - 0 (MicroRNAs)
SB  - IM
MH  - Computational Biology
MH  - *Diabetes Mellitus, Type 2/genetics
MH  - *Ferroptosis/genetics
MH  - Gene Expression Profiling
MH  - Humans
MH  - *MicroRNAs/genetics
PMC - PMC9309693
OTO - NOTNLM
OT  - T2DM
OT  - WGCNA
OT  - bioinformatic
OT  - ferroptosis
OT  - islet beta cell
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/07/29 06:00
MHDA- 2022/07/30 06:00
PMCR- 2022/01/01
CRDT- 2022/07/28 02:08
PHST- 2022/03/25 00:00 [received]
PHST- 2022/06/10 00:00 [accepted]
PHST- 2022/07/28 02:08 [entrez]
PHST- 2022/07/29 06:00 [pubmed]
PHST- 2022/07/30 06:00 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fendo.2022.904312 [doi]
PST - epublish
SO  - Front Endocrinol (Lausanne). 2022 Jul 11;13:904312. doi: 
      10.3389/fendo.2022.904312. eCollection 2022.