PMID- 35898550 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20220729 IS - 2297-1769 (Print) IS - 2297-1769 (Electronic) IS - 2297-1769 (Linking) VI - 9 DP - 2022 TI - Research Progress on the NSP9 Protein of Porcine Reproductive and Respiratory Syndrome Virus. PG - 872205 LID - 10.3389/fvets.2022.872205 [doi] LID - 872205 AB - Porcine reproductive and respiratory syndrome (PRRS) is a contagious disease caused by the porcine reproductive and respiratory syndrome virus (PRRSV). PRRS is also called "blue ear disease" because of the characteristic blue ear in infected sows and piglets. Its main clinical features are reproductive disorders of sows, breathing difficulties in piglets, and fattening in pigs, which cause considerable losses to the swine industry. NSP9, a non-structural protein of PRRSV, plays a vital role in PRRSV replication and virulence because of its RNA-dependent RNA polymerase (RdRp) structure. The NSP9 sequence is highly conserved and contains T cell epitopes, which are beneficial for the development of future vaccines. NSP9 acts as the protein interaction hub between virus and host during PRRSV infection, especially in RNA replication and transcription. Herein, we comprehensively review the application of NSP9 in terms of genetic evolution analysis, interaction with host proteins that affect virus replication, interaction with other viral proteins, pathogenicity, regulation of cellular immune response, antiviral drugs, vaccines, and detection methods. This review can therefore provide innovative ideas and strategies for PRRSV prevention and control. CI - Copyright (c) 2022 Sha, Zhang, Chen, Huang, Zhao and Wang. FAU - Sha, Huiyang AU - Sha H AD - Department of Veterinary Medicine, School of Life Science and Engineering, Foshan University, Foshan, China. AD - Veterinary Teaching Hospital, Foshan University, Foshan, China. FAU - Zhang, Hang AU - Zhang H AD - Department of Veterinary Medicine, School of Life Science and Engineering, Foshan University, Foshan, China. AD - Veterinary Teaching Hospital, Foshan University, Foshan, China. FAU - Chen, Yao AU - Chen Y AD - Department of Veterinary Medicine, School of Life Science and Engineering, Foshan University, Foshan, China. AD - Veterinary Teaching Hospital, Foshan University, Foshan, China. FAU - Huang, Liangzong AU - Huang L AD - Department of Veterinary Medicine, School of Life Science and Engineering, Foshan University, Foshan, China. AD - Veterinary Teaching Hospital, Foshan University, Foshan, China. FAU - Zhao, Mengmeng AU - Zhao M AD - Department of Veterinary Medicine, School of Life Science and Engineering, Foshan University, Foshan, China. AD - Veterinary Teaching Hospital, Foshan University, Foshan, China. FAU - Wang, Nina AU - Wang N AD - Department of Veterinary Medicine, School of Life Science and Engineering, Foshan University, Foshan, China. AD - Veterinary Teaching Hospital, Foshan University, Foshan, China. LA - eng PT - Journal Article PT - Review DEP - 20220711 PL - Switzerland TA - Front Vet Sci JT - Frontiers in veterinary science JID - 101666658 PMC - PMC9309524 OTO - NOTNLM OT - NSP9 OT - PRRSV OT - RdRp OT - pathogenicity OT - protein interaction COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2022/07/29 06:00 MHDA- 2022/07/29 06:01 PMCR- 2022/01/01 CRDT- 2022/07/28 02:10 PHST- 2022/02/09 00:00 [received] PHST- 2022/06/20 00:00 [accepted] PHST- 2022/07/28 02:10 [entrez] PHST- 2022/07/29 06:00 [pubmed] PHST- 2022/07/29 06:01 [medline] PHST- 2022/01/01 00:00 [pmc-release] AID - 10.3389/fvets.2022.872205 [doi] PST - epublish SO - Front Vet Sci. 2022 Jul 11;9:872205. doi: 10.3389/fvets.2022.872205. eCollection 2022.