PMID- 35898588
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220729
IS  - 2296-875X (Print)
IS  - 2296-875X (Electronic)
IS  - 2296-875X (Linking)
VI  - 9
DP  - 2022
TI  - Correlation Between Serum beta2-GPI/oxLDL and the Risk of Cerebral Infarction in 
      Patients with T2DM.
PG  - 930701
LID - 10.3389/fsurg.2022.930701 [doi]
LID - 930701
AB  - OBJECTIVE: This study aims to study the correlation between serum beta2-glycoprotein 
      I (beta2-GPI)/oxidized low-density lipoprotein (oxLDL) and the risk of cerebral 
      infarction in patients with type 2 diabetes (T2DM). METHODS: From January 2019 to 
      March 2021, 56 patients with T2DM combined with cerebral infarction were chosen 
      as a diabetic cerebral infarction (DCI) group, and 60 patients with simple T2DM 
      were chosen as a T2DM group. In addition, 60 healthy volunteers were recruited as 
      a control group. The essential information of each group was collected, and the 
      serum beta2-GPI/oxLDL and inflammatory factor levels in each group were compared. 
      The clinical factors that affect the risk of ischemic cerebral infarction in 
      patients with T2DM were analyzed by a logistic model. RESULTS: Compared with the 
      control group, the level of serum beta2-GPI/oxLDL in the T2DM and DCI groups 
      increased significantly, P < 0.001. Compared with the T2DM group, the serum 
      beta2-GPI/oxLDL level in the DCI group increased significantly, P < 0.05. The result 
      of Pearson's correlation analysis showed that serum beta2-GPI/oxLDL was positively 
      correlated with total cholesterol, triglycerides, fasting blood glucose, 2-h 
      postprandial blood glucose, glycosylated hemoglobin, interleukin-6, and tumor 
      necrosis factor (TNF)-alpha (all P's < 0.05). Serum TNF-alpha and beta2-GPI/oxLDL were 
      independent risk variates for DCI (P < 0.05). Based on the receiver operating 
      characteristic curve analysis, the values of the area under the curve for TNF-alpha, 
      serum beta2-GPI/oxLDL, and the combined diagnosis of DCI were 0.653 (0.552-0.753), 
      0.680 (0.583-0.777), 0.739 (0.647-0.831), respectively. CONCLUSION: In DCI 
      patients, the levels of serum oxLDL/beta2-GPI are significantly increased. Serum 
      oxLDL/beta2-GPI is an independent risk factor that affects the occurrence of DCI. In 
      addition, the serum beta2-GPI/oxLDL level implicates the lipid metabolism and 
      inflammatory status of the internal environment of DCI patients to a certain 
      extent.
CI  - Copyright (c) 2022 Kuang, Li, Liu, Zhang, Chen, Luo and Kuang.
FAU - Kuang, Wending
AU  - Kuang W
AD  - The Second Affiliated Hospital, Department of Neurology, Hengyang Medical School, 
      University of South China, Hengyang, China.
FAU - Li, Yi
AU  - Li Y
AD  - Department of Diagnosis, Hengyang Medical School, University of South China, 
      Hengyang, China.
FAU - Liu, Gang
AU  - Liu G
AD  - The Second Affiliated Hospital, Department of Endocrinology, Hengyang Medical 
      School, University of South China, Hengyang, China.
FAU - Zhang, Yang
AU  - Zhang Y
AD  - The Second Affiliated Hospital, Department of Neurology, Hengyang Medical School, 
      University of South China, Hengyang, China.
FAU - Chen, Gang
AU  - Chen G
AD  - The Second Affiliated Hospital, Department of Neurology, Hengyang Medical School, 
      University of South China, Hengyang, China.
FAU - Luo, Bang
AU  - Luo B
AD  - The Second Affiliated Hospital, Department of Neurology, Hengyang Medical School, 
      University of South China, Hengyang, China.
FAU - Kuang, Shuangyu
AU  - Kuang S
AD  - The Second Affiliated Hospital, Department of GCP, Hengyang Medical School, 
      University of South China, Hengyang, China.
LA  - eng
PT  - Journal Article
DEP - 20220711
PL  - Switzerland
TA  - Front Surg
JT  - Frontiers in surgery
JID - 101645127
PMC - PMC9309478
OTO - NOTNLM
OT  - T2DM
OT  - cerebral infarction
OT  - oxLDL
OT  - type 2 diabetes
OT  - beta2-GPI
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/07/29 06:00
MHDA- 2022/07/29 06:01
PMCR- 2022/07/11
CRDT- 2022/07/28 02:11
PHST- 2022/04/28 00:00 [received]
PHST- 2022/06/02 00:00 [accepted]
PHST- 2022/07/28 02:11 [entrez]
PHST- 2022/07/29 06:00 [pubmed]
PHST- 2022/07/29 06:01 [medline]
PHST- 2022/07/11 00:00 [pmc-release]
AID - 10.3389/fsurg.2022.930701 [doi]
PST - epublish
SO  - Front Surg. 2022 Jul 11;9:930701. doi: 10.3389/fsurg.2022.930701. eCollection 
      2022.