PMID- 35900803
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231103
IS  - 2049-3614 (Print)
IS  - 2049-3614 (Electronic)
IS  - 2049-3614 (Linking)
VI  - 11
IP  - 9
DP  - 2022 Sep 1
TI  - Cardiovascular risk factors in mild adrenal autonomous cortisol secretion in a 
      Caucasian population.
LID - e220074 [pii]
LID - 10.1530/EC-22-0074 [doi]
AB  - Cardiovascular risk factors could be present in mild adrenal autonomous cortisol 
      secretion (MACS). However, the most frequent cardiovascular risk factors in MACS 
      have not been established. The aim of the presseent study was to analyse the 
      difference in cardiovascular risk factors in patients with MACS in comparison to 
      those with non-functioning adrenal tumour (NFAT). A total of 295 patients with 
      adrenal incidentaloma were included in this retrospective study. We divided our 
      group into those who showed suppression in 1 mg overnight dexamethasone 
      suppression test (DST) (NFAT) (serum cortisol level </=1.8 mug/dL) and those who did 
      not show suppression in the DST (MACS) (serum concentration of cortisol > 1.8 
      mug/dL and </=5 mug/dL). In the studied groups, we analysed the presence of 
      cardiovascular risk factors, such as obesity, prediabetes, type 2 diabetes 
      mellitus (T2DM), hypertension, hyperlipidaemia, chronic kidney disease and 
      cardiovascular events. In our study, 18.9% of patients were defined as MACS. 
      Importantly, T2DM was diagnosed in 41% of MACS vs 23% of NFAT (P < 0.01) and 
      higher frequency of occurrence of hyperlipidaemia in NFAT (72.4%) vs MACS (53.6%) 
      (P = 0.01) was observed. We did not observed differences in the frequency of 
      obesity, hypertension, chronic kidney disease, prediabetes, atrial fibrillation, 
      stroke, ST and non-ST elevation myocardial infarction and coronary angioplasty 
      between patients with MACS and NFAT (all P > 0.05; respectively). In MACS, T2DM 
      is more prevalent than in NFAT; hyperlipidaemia is more prevalent in NFAT. 
      Accordingly, no differences were found in the incidence of obesity, hypertension, 
      prediabetes, chronic kidney disease between studied groups as well as 
      cardiovascular events.
FAU - Adamska, Agnieszka
AU  - Adamska A
AUID- ORCID: 0000-0002-2544-130X
AD  - Department of Endocrinology, Diabetology and Internal Medicine, Medical 
      University of Bialystok, Bialystok, Poland.
FAU - Ulychnyi, Vitalii
AU  - Ulychnyi V
AD  - Department of Endocrinology, Diabetology and Internal Medicine, Medical 
      University of Bialystok, Bialystok, Poland.
FAU - Siewko, Katarzyna
AU  - Siewko K
AD  - Department of Endocrinology, Diabetology and Internal Medicine, Medical 
      University of Bialystok, Bialystok, Poland.
FAU - Poplawska-Kita, Anna
AU  - Poplawska-Kita A
AD  - Department of Endocrinology, Diabetology and Internal Medicine, Medical 
      University of Bialystok, Bialystok, Poland.
FAU - Szelachowska, Malgorzata
AU  - Szelachowska M
AD  - Department of Endocrinology, Diabetology and Internal Medicine, Medical 
      University of Bialystok, Bialystok, Poland.
FAU - Adamski, Marcin
AU  - Adamski M
AD  - Faculty of Computer Science, Bialystok University of Technology, Bialystok, 
      Poland.
FAU - Buczynska, Angelika
AU  - Buczynska A
AD  - Clinical Research Centre, Medical University of Bialystok, Bialystok, Poland.
FAU - Kretowski, Adam Jacek
AU  - Kretowski AJ
AD  - Department of Endocrinology, Diabetology and Internal Medicine, Medical 
      University of Bialystok, Bialystok, Poland.
AD  - Clinical Research Centre, Medical University of Bialystok, Bialystok, Poland.
LA  - eng
PT  - Journal Article
DEP - 20220804
PL  - England
TA  - Endocr Connect
JT  - Endocrine connections
JID - 101598413
PMC - PMC9422244
OTO - NOTNLM
OT  - adrenal incidentaloma
OT  - hyperlipidaemia
OT  - type 2 diabetes
EDAT- 2022/07/29 06:00
MHDA- 2022/07/29 06:01
PMCR- 2022/07/12
CRDT- 2022/07/28 11:44
PHST- 2022/05/22 00:00 [received]
PHST- 2022/07/12 00:00 [accepted]
PHST- 2022/07/29 06:00 [pubmed]
PHST- 2022/07/29 06:01 [medline]
PHST- 2022/07/28 11:44 [entrez]
PHST- 2022/07/12 00:00 [pmc-release]
AID - e220074 [pii]
AID - EC-22-0074 [pii]
AID - 10.1530/EC-22-0074 [doi]
PST - epublish
SO  - Endocr Connect. 2022 Aug 4;11(9):e220074. doi: 10.1530/EC-22-0074. Print 2022 Sep 
      1.