PMID- 3590225
OWN - NLM
STAT- MEDLINE
DCOM- 19870710
LR  - 20190819
IS  - 0378-4274 (Print)
IS  - 0378-4274 (Linking)
VI  - 37
IP  - 1
DP  - 1987 Jun
TI  - Dermal absorption of the antioxidant 4,4'-thiobis(6-tert-butyl-m-cresol) in 
      Sencar mice and Fischer rats.
PG  - 13-9
AB  - The dermal absorption of 14C-labeled 4,4'-thiobis(6-tert-butyl-m-cresol) (TBBC) 
      was studied in female Sencar mice and male Fischer rats. Dermal application 
      resulted in about 20% absorption in mice with more than 70% of the initial body 
      burden (IBB) remaining on the treated skin site 3 days after treatment. In rats, 
      less than 2% of a dermal dose was absorbed. This is in agreement with previous in 
      vitro percutaneous absorption studies which have demonstrated that mouse skin is 
      more permeable than rat skin to certain chemicals. Absorption did not increase 
      linearly as the dose increased. Oral and i.v. exposures were conducted in the 
      Sencar mice and compared to previously published rat oral and i.v. data. The 
      disposition was similar between rats and mice after these routes of exposures, 
      and the major route of elimination of absorbed TBBC was the feces in both 
      species.
FAU - Birnbaum, L S
AU  - Birnbaum LS
FAU - Heaney, S M
AU  - Heaney SM
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Netherlands
TA  - Toxicol Lett
JT  - Toxicology letters
JID - 7709027
RN  - 0 (Antioxidants)
RN  - 0 (Cresols)
RN  - 96-69-5 (4,4'-thiobis(6-tert-butyl-3-cresol))
SB  - IM
MH  - Administration, Cutaneous
MH  - Administration, Oral
MH  - Animals
MH  - Antioxidants/administration & dosage/*metabolism
MH  - Body Burden
MH  - Cresols/administration & dosage/*metabolism
MH  - Dose-Response Relationship, Drug
MH  - Feces/analysis
MH  - Female
MH  - Injections, Intravenous
MH  - Male
MH  - Mice
MH  - Rats
MH  - Rats, Inbred F344
MH  - *Skin Absorption
MH  - Species Specificity
EDAT- 1987/06/01 00:00
MHDA- 1987/06/01 00:01
CRDT- 1987/06/01 00:00
PHST- 1987/06/01 00:00 [pubmed]
PHST- 1987/06/01 00:01 [medline]
PHST- 1987/06/01 00:00 [entrez]
AID - 0378-4274(87)90161-5 [pii]
AID - 10.1016/0378-4274(87)90161-5 [doi]
PST - ppublish
SO  - Toxicol Lett. 1987 Jun;37(1):13-9. doi: 10.1016/0378-4274(87)90161-5.