PMID- 35902460
OWN - NLM
STAT- MEDLINE
DCOM- 20230410
LR  - 20230410
IS  - 1573-6830 (Electronic)
IS  - 0272-4340 (Linking)
VI  - 43
IP  - 4
DP  - 2023 May
TI  - Defensive and Emotional Behavior Modulation by Serotonin in the Periaqueductal 
      Gray.
PG  - 1453-1468
LID - 10.1007/s10571-022-01262-z [doi]
AB  - Serotonin 5-hydroxytryptamine (5-HT) is a key neurotransmitter for the modulation 
      and/or regulation of numerous physiological processes and psychiatric disorders 
      (e.g., behaviors related to anxiety, pain, aggressiveness, etc.). The 
      periaqueductal gray matter (PAG) is considered an integrating center for active 
      and passive defensive behaviors, and electrical stimulation of this area has been 
      shown to evoke behavioral responses of panic, fight-flight, freezing, among 
      others. The serotonergic activity in PAG is influenced by the activation of other 
      brain areas such as the medial hypothalamus, paraventricular nucleus of the 
      hypothalamus, amygdala, dorsal raphe nucleus, and ventrolateral orbital cortex. 
      In addition, activation of other receptors within PAG (i.e., CB1, Oxytocin, 
      micro-opioid receptor (MOR), and gamma-aminobutyric acid (GABA(A))) promotes serotonin 
      release. Therefore, this review aims to document evidence suggesting that the 
      PAG-evoked behavioral responses of anxiety, panic, fear, analgesia, and 
      aggression are influenced by the activation of 5-HT(1A) and 5-HT(2A/C) receptors 
      and their participation in the treatment of various mental disorders.
CI  - (c) 2022. The Author(s), under exclusive licence to Springer Science+Business 
      Media, LLC, part of Springer Nature.
FAU - Vazquez-Leon, Priscila
AU  - Vazquez-Leon P
AD  - Neuropsychopharmacology Laboratory, Psychology School. 1er Piso Edif. B. Cub 
      B001, National Autonomous University of Mexico, Avenida Universidad 3000, Colonia 
      Copilco Universidad. Alcaldia de Coyoacan, Mexico City, Mexico.
FAU - Miranda-Paez, Abraham
AU  - Miranda-Paez A
AD  - Department of Physiology, National School of Biological Sciences, National 
      Polytechnic Institute, Wilfrido Massieu esq. Manuel Stampa S/N Col. Nueva 
      Industrial Vallejo, Gustavo A. Madero, Mexico City, CP:07738, Mexico.
FAU - Valencia-Flores, Kenji
AU  - Valencia-Flores K
AD  - Neuropsychopharmacology Laboratory, Psychology School. 1er Piso Edif. B. Cub 
      B001, National Autonomous University of Mexico, Avenida Universidad 3000, Colonia 
      Copilco Universidad. Alcaldia de Coyoacan, Mexico City, Mexico.
FAU - Sanchez-Castillo, Hugo
AU  - Sanchez-Castillo H
AD  - Neuropsychopharmacology Laboratory, Psychology School. 1er Piso Edif. B. Cub 
      B001, National Autonomous University of Mexico, Avenida Universidad 3000, Colonia 
      Copilco Universidad. Alcaldia de Coyoacan, Mexico City, Mexico. 
      hugosancas@gmail.com.
AD  - Research Unit of Psychobiology and Neurosciences (UIPyN), Psychology School, 
      UNAM, CDMX Mexico, CP 04510, Mexico. hugosancas@gmail.com.
LA  - eng
GR  - Programa de Becas Posdoctorales 2022/Direccion General de Asuntos del Personal 
      Academico, Universidad Nacional Autonoma de Mexico/
GR  - IN 208722/Direccion General de Asuntos del Personal Academico, Universidad 
      Nacional Autonoma de Mexico/
PT  - Journal Article
PT  - Review
DEP - 20220728
PL  - United States
TA  - Cell Mol Neurobiol
JT  - Cellular and molecular neurobiology
JID - 8200709
RN  - 333DO1RDJY (Serotonin)
SB  - IM
MH  - Humans
MH  - *Serotonin
MH  - *Periaqueductal Gray/physiology
MH  - Emotions
MH  - Anxiety
MH  - Dorsal Raphe Nucleus
OTO - NOTNLM
OT  - Aggressiveness
OT  - Anticonception
OT  - Anxiety
OT  - Fear
OT  - Panic
OT  - Periaqueductal gray
OT  - Serotonin
EDAT- 2022/07/29 06:00
MHDA- 2023/04/10 06:41
CRDT- 2022/07/28 23:16
PHST- 2022/04/18 00:00 [received]
PHST- 2022/07/13 00:00 [accepted]
PHST- 2023/04/10 06:41 [medline]
PHST- 2022/07/29 06:00 [pubmed]
PHST- 2022/07/28 23:16 [entrez]
AID - 10.1007/s10571-022-01262-z [pii]
AID - 10.1007/s10571-022-01262-z [doi]
PST - ppublish
SO  - Cell Mol Neurobiol. 2023 May;43(4):1453-1468. doi: 10.1007/s10571-022-01262-z. 
      Epub 2022 Jul 28.