PMID- 35903442
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230308
IS  - 2296-861X (Print)
IS  - 2296-861X (Electronic)
IS  - 2296-861X (Linking)
VI  - 9
DP  - 2022
TI  - Habitual Fish Oil Supplementation and Risk of Incident Inflammatory Bowel 
      Diseases: A Prospective Population-Based Study.
PG  - 905162
LID - 10.3389/fnut.2022.905162 [doi]
LID - 905162
AB  - BACKGROUND: Inflammatory Bowel Diseases (IBDs) have been emerging in recent years 
      with the advance of global industrialization and diet pattern transformation. 
      Marine n-3 polyunsaturated fatty acids (n-3 PUFAs), enriched in fish oils, have 
      well-known human health promotion. Evidence on the association of fish oil 
      supplementation with the risk of developing IBDs was scarce. This study aimed to 
      examine the association between the use of fish oil supplements and the risk of 
      developing inflammatory bowel diseases (IBDs) among the general population. 
      METHODS: We conducted a prospective cohort study of 447,890 participants aged 
      40-69 years from the UK Biobank. A touch screen questionnaire was used to get the 
      data about fish oil intake at baseline. Incident diagnoses of IBDs were 
      ascertained by the International Classification of Diseases (ICD-9 and ICD-10) or 
      self-report. Cox proportional hazards model was applied to calculate hazard 
      ratios (HRs) and 95% confidence intervals (CIs) of developing IBDs and their 
      subtypes. RESULTS: We documented 1,646 incident cases of IBDs, including 533 
      incident cases of Crohn's disease (CD) and 1,185 incident cases of ulcerative 
      colitis (UC) during an average of 8 years of follow-up. After multivariate 
      adjustment, the use of fish oil was associated with a 12% lower risk of IBDs (HR: 
      0.88, 95% CI: 0.78-0.99, p = 0.03) compared with non-consumers. For subtypes of 
      IBDs, fish oil supplementation was inversely associated with a 15% lower risk of 
      UC (HR: 0.85, 95% CI: 0.75-0.99, p = 0.02) but was not correlated with the risk 
      of CD (p = 0.22). Besides, fish oil supplementation showed a significant inverse 
      correlation with baseline CRP levels (beta = -0.021, p < 0.001) and a positive 
      association with baseline albumin levels (beta = 0.135, p < 0.001) after adjustment 
      for multiple variates. CONCLUSION: Habitual intake of fish oil supplements was 
      associated with a lower risk of IBDs and UC. Fish oil users tended to have lower 
      baseline C-reactive protein levels and higher baseline albumin levels compared 
      with non-users. It was concluded that fish oil supplement use may be recommended 
      for the prevention and control of IBDs.
CI  - Copyright (c) 2022 Huang, Li, Zhuang, Liu, Zhang, Zhang and Jiao.
FAU - Huang, Xiaoxu
AU  - Huang X
AD  - Department of Clinical Nutrition, The Second Affiliated Hospital, Zhejiang 
      University School of Medicine, Hangzhou, China.
FAU - Li, Yin
AU  - Li Y
AD  - Department of Nutrition, School of Public Health, Department of Clinical 
      Nutrition, The Second Affiliated Hospital, Zhejiang University School of 
      Medicine, Hangzhou, China.
FAU - Zhuang, Pan
AU  - Zhuang P
AD  - Department of Food Science and Nutrition, Zhejiang Key Laboratory for Agro-Food 
      Processing, Fuli Institute of Food Science, College of Biosystems Engineering and 
      Food Science, Zhejiang University, Hangzhou, China.
FAU - Liu, Xiaohui
AU  - Liu X
AD  - Department of Nutrition, School of Public Health, Department of Clinical 
      Nutrition, The Second Affiliated Hospital, Zhejiang University School of 
      Medicine, Hangzhou, China.
FAU - Zhang, Yu
AU  - Zhang Y
AD  - Department of Food Science and Nutrition, Zhejiang Key Laboratory for Agro-Food 
      Processing, Fuli Institute of Food Science, College of Biosystems Engineering and 
      Food Science, Zhejiang University, Hangzhou, China.
FAU - Zhang, Pianhong
AU  - Zhang P
AD  - Department of Clinical Nutrition, The Second Affiliated Hospital, Zhejiang 
      University School of Medicine, Hangzhou, China.
FAU - Jiao, Jingjing
AU  - Jiao J
AD  - Department of Clinical Nutrition, The Second Affiliated Hospital, Zhejiang 
      University School of Medicine, Hangzhou, China.
AD  - Department of Nutrition, School of Public Health, Department of Clinical 
      Nutrition, The Second Affiliated Hospital, Zhejiang University School of 
      Medicine, Hangzhou, China.
LA  - eng
GR  - MC_PC_17228/MRC_/Medical Research Council/United Kingdom
GR  - MC_QA137853/MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
DEP - 20220712
PL  - Switzerland
TA  - Front Nutr
JT  - Frontiers in nutrition
JID - 101642264
PMC - PMC9315369
OTO - NOTNLM
OT  - C-reactive protein
OT  - Crohn's disease
OT  - UK Biobank
OT  - album
OT  - fish oil supplementation
OT  - inflammatory bowel diseases
OT  - ulcerative colitis
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/07/30 06:00
MHDA- 2022/07/30 06:01
PMCR- 2022/01/01
CRDT- 2022/07/29 02:01
PHST- 2022/03/26 00:00 [received]
PHST- 2022/06/13 00:00 [accepted]
PHST- 2022/07/29 02:01 [entrez]
PHST- 2022/07/30 06:00 [pubmed]
PHST- 2022/07/30 06:01 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fnut.2022.905162 [doi]
PST - epublish
SO  - Front Nutr. 2022 Jul 12;9:905162. doi: 10.3389/fnut.2022.905162. eCollection 
      2022.