PMID- 35903571
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220731
IS  - 2168-8184 (Print)
IS  - 2168-8184 (Electronic)
IS  - 2168-8184 (Linking)
VI  - 14
IP  - 6
DP  - 2022 Jun
TI  - Light Chain Deposition Disease: A Morphological Case Report.
PG  - e26357
LID - 10.7759/cureus.26357 [doi]
LID - e26357
AB  - Light chain deposition disease (LCDD) is a rare condition associated with the 
      overproduction and deposition of monoclonal light chain immunoglobulins. The 
      kidneys are universally affected in LCDD, with the development of renal failure 
      with nephrotic syndrome, microscopic hematuria, and proteinuria. Most cases are 
      associated with a plasma cell neoplasm (multiple myeloma or plasmacytoma) or 
      other lymphoproliferative disorders, with a reasonable number of cases also being 
      idiopathic. Other organs can be affected in rare cases, without producing 
      significant symptoms, predominantly the liver and heart. In this report, 
      we discuss a case of a 72-year-old female presenting with the aforementioned 
      symptoms. Percutaneous ultrasound-guided kidney biopsy revealed nodular sclerosis 
      with periodic acid-Schiff stain (PAS)-positive, Congo red-negative, silver 
      impregnation weakly-positive, and Masson's trichrome-positive (red reaction) 
      deposits with ribbon-like changes together with light chain deposits in the 
      tubular basement membranes. As LCDD was diagnosed, the patient was subjected to 
      further tests, with multiple myeloma of the thoracic vertebrae also being 
      diagnosed. The patient was started on myeloma treatment; however, she 
      subsequently developed a severe lower limb infection that required amputation, 
      after which she developed sepsis and expired.
CI  - Copyright (c) 2022, Popov et al.
FAU - Popov, Hristo
AU  - Popov H
AD  - General and Clinical Pathology/Forensic Medicine and Deontology, Medical 
      University of Varna, Varna, BGR.
FAU - Stoyanov, George S
AU  - Stoyanov GS
AD  - General and Clinical Pathology, St. Marina University Hospital, Varna, BGR.
AD  - General and Clinical Pathology/Forensic Medicine and Deontology, Medical 
      University of Varna, Varna, BGR.
FAU - Ghenev, Peter
AU  - Ghenev P
AD  - General and Clinical Pathology/Forensic Medicine and Deontology, Medical 
      University of Varna, Varna, BGR.
LA  - eng
PT  - Case Reports
DEP - 20220627
PL  - United States
TA  - Cureus
JT  - Cureus
JID - 101596737
PMC - PMC9326408
OTO - NOTNLM
OT  - case report
OT  - kidney
OT  - light chain deposition disease
OT  - monoclonal immunoglobulin deposition disease
OT  - multiple myeloma
OT  - nephropathology
COIS- The authors would like to disclose that one of the authors (George Stoyanov, MD, 
      Ph.D.) was a member of the editorial approval board of the journal (Cureus 
      Journal of Medical Science) at the time of the manuscript submission. The authors 
      affirm that this in no way, shape, or form resulted in manipulating the reviewer 
      selection process, reviews themselves, or the initial or final editorial 
      decision.
EDAT- 2022/07/30 06:00
MHDA- 2022/07/30 06:01
PMCR- 2022/06/27
CRDT- 2022/07/29 02:04
PHST- 2022/06/26 00:00 [accepted]
PHST- 2022/07/29 02:04 [entrez]
PHST- 2022/07/30 06:00 [pubmed]
PHST- 2022/07/30 06:01 [medline]
PHST- 2022/06/27 00:00 [pmc-release]
AID - 10.7759/cureus.26357 [doi]
PST - epublish
SO  - Cureus. 2022 Jun 27;14(6):e26357. doi: 10.7759/cureus.26357. eCollection 2022 
      Jun.