PMID- 35903803 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20230315 IS - 2632-7899 (Electronic) IS - 2632-7899 (Linking) VI - 3 IP - 1 DP - 2022 Jan TI - The Relationship Between Grey Matter Volume and Clinical and Functional Outcomes in People at Clinical High Risk for Psychosis. PG - sgac040 LID - 10.1093/schizbullopen/sgac040 [doi] LID - sgac040 AB - OBJECTIVE: To examine the association between baseline alterations in grey matter volume (GMV) and clinical and functional outcomes in people at clinical high risk (CHR) for psychosis. METHODS: 265 CHR individuals and 92 healthy controls were recruited as part of a prospective multi-center study. After a baseline assessment using magnetic resonance imaging (MRI), participants were followed for at least two years to determine clinical and functional outcomes, including transition to psychosis (according to the Comprehensive Assessment of an At Risk Mental State, CAARMS), level of functioning (according to the Global Assessment of Functioning), and symptomatic remission (according to the CAARMS). GMV was measured in selected cortical and subcortical regions of interest (ROI) based on previous studies (ie orbitofrontal gyrus, cingulate gyrus, gyrus rectus, inferior temporal gyrus, parahippocampal gyrus, striatum, and hippocampus). Using voxel-based morphometry, we analysed the relationship between GMV and clinical and functional outcomes. RESULTS: Within the CHR sample, a poor functional outcome (GAF < 65) was associated with relatively lower GMV in the right striatum at baseline (P < .047 after Family Wise Error correction). There were no significant associations between baseline GMV and either subsequent remission or transition to psychosis. CONCLUSIONS: In CHR individuals, lower striatal GMV was associated with a poor level of overall functioning at follow-up. This finding was not related to effects of antipsychotic or antidepressant medication. The failure to replicate previous associations between GMV and later psychosis onset, despite studying a relatively large sample, is consistent with the findings of recent large-scale multi-center studies. CI - (c) The Author(s) 2022. Published by Oxford University Press on behalf of the University of Maryland's school of medicine, Maryland Psychiatric Research Center. FAU - Tognin, Stefania AU - Tognin S AUID- ORCID: 0000-0002-1983-9135 AD - Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK. FAU - Richter, Anja AU - Richter A AUID- ORCID: 0000-0002-0253-6111 AD - Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK. FAU - Kempton, Matthew J AU - Kempton MJ AD - Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK. FAU - Modinos, Gemma AU - Modinos G AUID- ORCID: 0000-0002-7870-066X AD - Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK. FAU - Antoniades, Mathilde AU - Antoniades M AD - Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK. FAU - Azis, Matilda AU - Azis M AUID- ORCID: 0000-0001-8164-0357 AD - Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK. FAU - Allen, Paul AU - Allen P AD - Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK. FAU - Bossong, Matthijs G AU - Bossong MG AD - Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK. FAU - Perez, Jesus AU - Perez J AD - CAMEO Early Intervention in Psychosis Services, Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, UK. FAU - Pantelis, Christos AU - Pantelis C AUID- ORCID: 0000-0002-9565-0238 AD - Department of Psychiatry, Melbourne Neuropsychiatry Centre, University of Melbourne & Melbourne Health, Carlton South, Victoria, Australia. FAU - Nelson, Barnaby AU - Nelson B AD - Orygen, Parkville, Victoria, Australia. FAU - Amminger, Paul AU - Amminger P AD - Orygen, Parkville, Victoria, Australia. FAU - Riecher-Rossler, Anita AU - Riecher-Rossler A AUID- ORCID: 0000-0001-6361-8789 AD - University of Basel, Faculty of Medicine, Basel, Switzerland. FAU - Barrantes-Vidal, Neus AU - Barrantes-Vidal N AUID- ORCID: 0000-0002-8671-1238 AD - Departament de Psicologia Clinica i de la Salut (Universitat Autonoma de Barcelona), Fundacio Sanitaria Sant Pere Claver (Spain), Center for Biomedical Research in Mental Health (CIBERSAM), Madrid, Spain. FAU - Krebs, Marie-Odile AU - Krebs MO AD - University of Paris, GHU-Paris, Sainte-Anne, C'JAAD, Hospitalo-Universitaire department SHU, Inserm U1266, Institut de Psychiatrie (CNRS 3557), Paris, France. FAU - Glenthoj, Birte AU - Glenthoj B AD - Center for Neuropsychiatric Schizophrenia Research, CNSR, and Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research, CINS, Mental Health Services Capital Region of Denmark, Mental Health Center Glostrup, Glostrup, Denmark. FAU - Ruhrmann, Stephan AU - Ruhrmann S AD - Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital University of Cologne, Cologne, Germany. FAU - Sachs, Gabriele AU - Sachs G AUID- ORCID: 0000-0002-8359-9877 AD - Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria. FAU - Rutten, Bart P F AU - Rutten BPF AD - Department of Psychiatry and Neuropsychology, Faculty of Health, Medicine and Life Sciences, School for Mental Health and Neuroscience (MHeNS), Maastricht University, Maastricht, The Netherlands. FAU - de Haan, Lieuwe AU - de Haan L AD - Early Psychosis Department, Amsterdam UMC, Amsterdam, The Netherlands. FAU - van der Gaag, Mark AU - van der Gaag M AD - Department of Clinical Psychology and Amsterdam Public Mental Health Research Institute, Faculty of Behavioural and Movement Sciences, VU University, Amsterdam, The Netherlands. CN - EU-GEI High Risk Study Group FAU - Valmaggia, Lucia R AU - Valmaggia LR AD - Department of Psychology, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK. FAU - McGuire, Philip AU - McGuire P AD - Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK. LA - eng GR - MR/J008915/1/MRC_/Medical Research Council/United Kingdom PT - Journal Article DEP - 20220620 PL - United States TA - Schizophr Bull Open JT - Schizophrenia bulletin open JID - 101770329 PMC - PMC9309497 OTO - NOTNLM OT - clinical high risk for psychosis OT - clinical outcomes OT - functioning OT - grey matter volume OT - remission OT - structural magnetic resonance imaging OT - transition to psychosis FIR - McGuire, Philip IR - McGuire P FIR - Valmaggia, Lucia R IR - Valmaggia LR FIR - Calem, Maria IR - Calem M FIR - Antoniades, Mathilde IR - Antoniades M FIR - Pisani, Sara IR - Pisani S FIR - Modinos, Gemma IR - Modinos G FIR - de Haan, Lieuwe IR - de Haan L FIR - van der Gaag, Mark IR - van der Gaag M FIR - Velthorst, Eva IR - Velthorst E FIR - Kraan, Tamar C IR - Kraan TC FIR - van Dam, Daniella S IR - van Dam DS FIR - Burger, Nadine IR - Burger N FIR - Nelson, Barnaby IR - Nelson B FIR - McGorry, Patrick IR - McGorry P FIR - Amminger, G Paul IR - Amminger GP FIR - Pantelis, Christos IR - Pantelis C FIR - Politis, Athena IR - Politis A FIR - Goodall, Joanne IR - Goodall J FIR - Riecher-Rossler, Anita IR - Riecher-Rossler A FIR - Borgwardt, Stefan IR - Borgwardt S FIR - Studerus, Erich IR - Studerus E FIR - Bressan, Rodrigo IR - Bressan R FIR - Gadelha, Ary IR - Gadelha A FIR - Brietzke, Elisa IR - Brietzke E FIR - Asevedo, Graccielle IR - Asevedo G FIR - Asevedo, Elson IR - Asevedo E FIR - Zugman, Andre IR - Zugman A FIR - Barrantes-Vidal, Neus IR - Barrantes-Vidal N FIR - Dominguez-Martinez, Tecelli IR - Dominguez-Martinez T FIR - Racciopi, Anna IR - Racciopi A FIR - Kwapil, Thomas R IR - Kwapil TR FIR - Monsonet, Manel IR - Monsonet M FIR - Hinojosa, Lidia IR - Hinojosa L FIR - Kazes, Mathilde IR - Kazes M FIR - Daban, Claire IR - Daban C FIR - Bourgin, Julie IR - Bourgin J FIR - Gay, Olivier IR - Gay O FIR - Mam-Lam-Fook, Celia IR - Mam-Lam-Fook C FIR - Krebs, Marie-Odile IR - Krebs MO FIR - Nordholm, Dorte IR - Nordholm D FIR - Randers, Lasse IR - Randers L FIR - Krakauer, Kristine IR - Krakauer K FIR - Glenthoj, Louise IR - Glenthoj L FIR - Glenthoj, Birte IR - Glenthoj B FIR - Nordentoft, Merete IR - Nordentoft M FIR - Ruhrmann, Stephan IR - Ruhrmann S FIR - Gebhard, Dominika IR - Gebhard D FIR - Arnhold, Julia IR - Arnhold J FIR - Klosterkotter, Joachim IR - Klosterkotter J FIR - Sachs, Gabriele IR - Sachs G FIR - Lasser, Iris IR - Lasser I FIR - Winklbaur, Bernadette IR - Winklbaur B FIR - Aschauer, Harald IR - Aschauer H FIR - Delespaul, Philippe A IR - Delespaul PA FIR - Rutten, Bart P IR - Rutten BP FIR - van Os, Jim IR - van Os J EDAT- 2022/07/30 06:00 MHDA- 2022/07/30 06:01 PMCR- 2022/06/20 CRDT- 2022/07/29 02:08 PHST- 2022/07/29 02:08 [entrez] PHST- 2022/07/30 06:00 [pubmed] PHST- 2022/07/30 06:01 [medline] PHST- 2022/06/20 00:00 [pmc-release] AID - sgac040 [pii] AID - 10.1093/schizbullopen/sgac040 [doi] PST - epublish SO - Schizophr Bull Open. 2022 Jun 20;3(1):sgac040. doi: 10.1093/schizbullopen/sgac040. eCollection 2022 Jan.