PMID- 35904275
OWN - NLM
STAT- MEDLINE
DCOM- 20230706
LR  - 20230706
IS  - 1439-7609 (Electronic)
IS  - 1439-7595 (Linking)
VI  - 33
IP  - 4
DP  - 2023 Jul 4
TI  - RS3PE syndrome: Autoinflammatory features of a rare disorder.
PG  - 640-646
LID - 10.1093/mr/roac071 [doi]
AB  - Remitting seronegative symmetrical synovitis with pitting oedema (RS3PE) syndrome 
      was first described by McCarty in 1985 and is characterized by pitting oedema and 
      an acute symmetrical synovitis of small joints. Self-directed inflammation in 
      autoimmune disorders is caused by an abnormal activation of the adaptive immune 
      system, while in autoinflammatory disorders, it is due to aberrant activation of 
      the innate immune system without autoantibodies or autoreactive T cells. The role 
      of autoimmunity in the pathogenesis of RS3PE syndrome is suggested by possible 
      associations with some autoimmune diseases and human leukocyte antigen (HLA) 
      haplotypes. However, several other features point to a possible role of 
      autoinflammation in RS3PE syndrome. In this review, the relative contributions of 
      both innate and adaptive immune systems to the pathogenesis of RS3PE syndrome are 
      discussed.
CI  - (c) Japan College of Rheumatology 2022. Published by Oxford University Press. All 
      rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
FAU - Borges, Tiago
AU  - Borges T
AUID- ORCID: 0000-0002-8271-9865
AD  - Department of Internal Medicine, Trofa Saude Gaia, Vila Nova de Gaia, Portugal.
FAU - Silva, Sergio
AU  - Silva S
AD  - Department of Internal Medicine, Trofa Saude Gaia, Vila Nova de Gaia, Portugal.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Mod Rheumatol
JT  - Modern rheumatology
JID - 100959226
SB  - IM
MH  - Humans
MH  - *Synovitis/complications
MH  - Syndrome
MH  - *Arthritis, Rheumatoid/complications
MH  - Edema
MH  - *Autoimmune Diseases/complications
OTO - NOTNLM
OT  - Arthritis
OT  - RS3PE syndrome
OT  - autoimmune disorder
OT  - autoinflammatory diseases
OT  - oedema
EDAT- 2022/07/30 06:00
MHDA- 2023/07/06 06:42
CRDT- 2022/07/29 08:22
PHST- 2022/04/14 00:00 [received]
PHST- 2022/05/28 00:00 [revised]
PHST- 2022/06/20 00:00 [accepted]
PHST- 2023/07/06 06:42 [medline]
PHST- 2022/07/30 06:00 [pubmed]
PHST- 2022/07/29 08:22 [entrez]
AID - 6651678 [pii]
AID - 10.1093/mr/roac071 [doi]
PST - ppublish
SO  - Mod Rheumatol. 2023 Jul 4;33(4):640-646. doi: 10.1093/mr/roac071.