PMID- 35904513
OWN - NLM
STAT- MEDLINE
DCOM- 20230510
LR  - 20230510
IS  - 1463-5224 (Electronic)
IS  - 1463-5216 (Linking)
VI  - 26 Suppl 1
DP  - 2023 Apr
TI  - Assessment of corneal and limbal epithelial thickness by spectral-domain optical 
      coherence tomography in brachycephalic and non-brachycephalic dogs.
PG  - 89-97
LID - 10.1111/vop.13016 [doi]
AB  - OBJECTIVE: To investigate the variance in corneal epithelial thickness (CET) and 
      limbal epithelial thickness (LET) according to the age and skull type by using 
      spectral-domain optical coherence tomography (SD-OCT) in normal dogs. ANIMALS AND 
      PROCEDURES: This study used an eye each from 46 dogs (24 brachycephalic and 22 
      non-brachycephalic dogs) assessed to have clear corneas. Each dog was classified 
      according to age into groups 1 (0-5 years), 2 (6-10 years), and 3 (>11 years). 
      OCT imaging was performed on the central cornea for CET and perpendicular to the 
      quadrant of the limbus for LET. The average of the maximum LET (maxLET) value was 
      measured in four eye quadrants. RESULTS: Corneal epithelial thickness was not 
      significantly different according to age in brachycephalic and non-brachycephalic 
      dogs. Visualization of the limbal invagination was better when the maxLET was 
      thick. Nasal and temporal maxLETs were significantly thicker than superior and 
      inferior maxLETs in non-brachycephalic dogs. In brachycephalic dogs, there was a 
      significant decrease in nasal maxLET with age (r(s)  = -0.489, p = .015). 
      Significant differences between brachycephalic and non-brachycephalic dogs were 
      observed in nasal maxLET (p = .024) and temporal maxLET (p = .011). CONCLUSIONS: 
      Invagination was better visualized in the nasal and temporal limbal quadrants of 
      non-brachycephalic dogs compared with brachycephalic dogs, and the maxLETs of the 
      regions were thicker than those of the brachycephalic dogs. CET and LET 
      measurements using SD-OCT can help in clinical assessment and research on ocular 
      surface diseases in dogs.
CI  - (c) 2022 American College of Veterinary Ophthalmologists.
FAU - Jeong, Youngseok
AU  - Jeong Y
AUID- ORCID: 0000-0002-6646-8277
AD  - Department of Veterinary Clinical Sciences, College of Veterinary Medicine and 
      Research Institute for Veterinary Science, Seoul National University, Seoul, 
      South Korea.
FAU - Kang, Seonmi
AU  - Kang S
AUID- ORCID: 0000-0001-8017-0891
AD  - Department of Veterinary Clinical Sciences, College of Veterinary Medicine and 
      Research Institute for Veterinary Science, Seoul National University, Seoul, 
      South Korea.
FAU - Ahn, Junyeong
AU  - Ahn J
AUID- ORCID: 0000-0001-6582-6100
AD  - Department of Veterinary Clinical Sciences, College of Veterinary Medicine and 
      Research Institute for Veterinary Science, Seoul National University, Seoul, 
      South Korea.
FAU - Kim, Sol
AU  - Kim S
AUID- ORCID: 0000-0003-2309-4620
AD  - Department of Veterinary Clinical Sciences, College of Veterinary Medicine and 
      Research Institute for Veterinary Science, Seoul National University, Seoul, 
      South Korea.
FAU - Kim, Hyelin
AU  - Kim H
AUID- ORCID: 0000-0002-4282-2884
AD  - Department of Veterinary Clinical Sciences, College of Veterinary Medicine and 
      Research Institute for Veterinary Science, Seoul National University, Seoul, 
      South Korea.
FAU - Park, Jisoo
AU  - Park J
AUID- ORCID: 0000-0002-8114-8570
AD  - Department of Veterinary Clinical Sciences, College of Veterinary Medicine and 
      Research Institute for Veterinary Science, Seoul National University, Seoul, 
      South Korea.
FAU - Seo, Kangmoon
AU  - Seo K
AUID- ORCID: 0000-0001-6645-7116
AD  - Department of Veterinary Clinical Sciences, College of Veterinary Medicine and 
      Research Institute for Veterinary Science, Seoul National University, Seoul, 
      South Korea.
LA  - eng
GR  - College of Veterinary Medicine, Seoul National University/
GR  - Research Institute for Veterinary Science (RIVS)/
GR  - BK21 FOUR Future Veterinary Medicine Leading Education and Research Center/
PT  - Journal Article
DEP - 20220729
PL  - England
TA  - Vet Ophthalmol
JT  - Veterinary ophthalmology
JID - 100887377
SB  - IM
MH  - Dogs
MH  - Animals
MH  - Tomography, Optical Coherence/veterinary/methods
MH  - *Epithelium, Corneal/diagnostic imaging
MH  - *Limbus Corneae/diagnostic imaging
MH  - Cornea
MH  - *Corneal Diseases/diagnostic imaging/veterinary
MH  - *Dog Diseases/diagnostic imaging
OTO - NOTNLM
OT  - SD-OCT
OT  - age
OT  - brachycephalic dogs
OT  - corneal epithelial thickness
OT  - limbal epithelial thickness
OT  - skull type
EDAT- 2022/07/30 06:00
MHDA- 2023/05/10 06:42
CRDT- 2022/07/29 10:53
PHST- 2022/07/12 00:00 [revised]
PHST- 2022/02/12 00:00 [received]
PHST- 2022/07/21 00:00 [accepted]
PHST- 2023/05/10 06:42 [medline]
PHST- 2022/07/30 06:00 [pubmed]
PHST- 2022/07/29 10:53 [entrez]
AID - 10.1111/vop.13016 [doi]
PST - ppublish
SO  - Vet Ophthalmol. 2023 Apr;26 Suppl 1:89-97. doi: 10.1111/vop.13016. Epub 2022 Jul 
      29.