PMID- 35905658
OWN - NLM
STAT- MEDLINE
DCOM- 20220919
LR  - 20220927
IS  - 1872-7603 (Electronic)
IS  - 0165-0378 (Linking)
VI  - 153
DP  - 2022 Sep
TI  - Soluble HLA-G blood levels are not increased during ongoing pregnancy in women 
      with a history of recurrent pregnancy loss.
PG  - 103665
LID - S0165-0378(22)00194-2 [pii]
LID - 10.1016/j.jri.2022.103665 [doi]
AB  - Recurrent pregnancy loss (RPL) affects 1-2 % of couples who are trying to 
      conceive. At some point, some couples do maintain a healthy pregnancy to term, 
      but the underlying mechanism of RPL remains elusive. Human leukocyte antigen 
      (HLA)-G is an immune modulatory molecule. Our group previously showed increased 
      HLA-G levels in the decidua of term pregnancies after RPL, while other studies 
      showed reduced soluble HLA-G (sHLA-G) blood levels in women with RPL. This led us 
      to investigate sHLA-G levels in blood of women with RPL who had either a 
      subsequent pregnancy loss (RPL-pregnancy loss) or a healthy term pregnancy 
      (RPL-live birth), and compare these to healthy control pregnancies and 
      non-pregnant controls. Soluble HLA-G concentrations were quantified by ELISA. 
      Women with healthy term pregnancy had increased sHLA-G levels compared to 
      non-pregnant controls. In contrast, RPL-live birth women at term did not have 
      increased blood sHLA-G levels. Soluble HLA-G levels remained stable between first 
      and third trimester. Interestingly, when comparing first trimester samples of 
      RPL-live birth to RPL-pregnancy loss, sHLA-G levels also did not significantly 
      differ. High sHLA-G levels in blood seem not to be crucial for an ongoing healthy 
      pregnancy after RPL. However, since it was previously shown that women with 
      RPL-live birth have increased HLA-G levels in term decidua compared to control 
      pregnancies, the current data suggest that local and systemic immune regulation 
      are not necessarily in concert. Further study of the contribution of 
      fetus-derived HLA-G and HLA-G of maternal origin may provide more insight in the 
      pathophysiology of RPL.
CI  - Copyright (c) 2022 The Authors. Published by Elsevier B.V. All rights reserved.
FAU - Krop, J
AU  - Krop J
AD  - Department of Immunology, Leiden University Medical Centre, Leiden, the 
      Netherlands.
FAU - Van Der Keur, C
AU  - Van Der Keur C
AD  - Department of Immunology, Leiden University Medical Centre, Leiden, the 
      Netherlands.
FAU - Kapsenberg, J M
AU  - Kapsenberg JM
AD  - Department of Immunology, Leiden University Medical Centre, Leiden, the 
      Netherlands.
FAU - Den Hollander, F
AU  - Den Hollander F
AD  - Department of Immunology, Leiden University Medical Centre, Leiden, the 
      Netherlands.
FAU - Van Der Hoorn, M L P
AU  - Van Der Hoorn MLP
AD  - Department of Obstetrics, Leiden University Medical Centre, Leiden, the 
      Netherlands.
FAU - Heidt, S
AU  - Heidt S
AD  - Department of Immunology, Leiden University Medical Centre, Leiden, the 
      Netherlands.
FAU - Claas, F H J
AU  - Claas FHJ
AD  - Department of Immunology, Leiden University Medical Centre, Leiden, the 
      Netherlands.
FAU - Eikmans, M
AU  - Eikmans M
AD  - Department of Immunology, Leiden University Medical Centre, Leiden, the 
      Netherlands. Electronic address: m.eikmans@lumc.nl.
LA  - eng
PT  - Journal Article
DEP - 20220720
PL  - Ireland
TA  - J Reprod Immunol
JT  - Journal of reproductive immunology
JID - 8001906
RN  - 0 (HLA-G Antigens)
SB  - IM
MH  - *Abortion, Habitual
MH  - Female
MH  - Fetus
MH  - *HLA-G Antigens
MH  - Humans
MH  - Pregnancy
MH  - Pregnancy Trimester, First
MH  - Pregnancy Trimester, Third
OTO - NOTNLM
OT  - BMI
OT  - HLA-G polymorphisms
OT  - RPL with subsequent ongoing pregnancy
OT  - Recurrent Pregnancy Loss
OT  - Soluble HLA-G
EDAT- 2022/07/30 06:00
MHDA- 2022/09/20 06:00
CRDT- 2022/07/29 18:23
PHST- 2022/01/13 00:00 [received]
PHST- 2022/05/30 00:00 [revised]
PHST- 2022/07/11 00:00 [accepted]
PHST- 2022/07/30 06:00 [pubmed]
PHST- 2022/09/20 06:00 [medline]
PHST- 2022/07/29 18:23 [entrez]
AID - S0165-0378(22)00194-2 [pii]
AID - 10.1016/j.jri.2022.103665 [doi]
PST - ppublish
SO  - J Reprod Immunol. 2022 Sep;153:103665. doi: 10.1016/j.jri.2022.103665. Epub 2022 
      Jul 20.