PMID- 35906156
OWN - NLM
STAT- MEDLINE
DCOM- 20220907
LR  - 20220907
IS  - 1875-2128 (Electronic)
IS  - 1875-2128 (Linking)
VI  - 115
IP  - 8-9
DP  - 2022 Aug-Sep
TI  - Determinants of left atrioventricular coupling index: The Multi-Ethnic Study of 
      Atherosclerosis (MESA).
PG  - 414-425
LID - S1875-2136(22)00134-6 [pii]
LID - 10.1016/j.acvd.2022.04.011 [doi]
AB  - BACKGROUND: Recent studies have described a novel left atrioventricular coupling 
      index (LACI), which had a better prognostic value in predicting cardiovascular 
      events than individual left atrial (LA) or left ventricular (LV) variables. AIMS: 
      To identify determinants of LACI and its 10-year annual change (DeltaLACI), measured 
      by cardiac magnetic resonance (CMR), and to better understand the variables 
      governing this left atrioventricular coupling. METHODS: In the Multi-Ethnic Study 
      of Atherosclerosis, 2112 study participants, free from cardiovascular disease at 
      baseline, had LACI assessed by CMR imaging at baseline (LACI(Baseline); 
      2000-2002) and 10 years later (2010-2012). The LACI was defined as the ratio of 
      LA to LV end-diastolic volumes. Linear regression analyses were performed to 
      identify independent determinants of LACI(Baseline) and DeltaLACI. RESULTS: In the 
      2112 participants (mean age 58.8+/-9.1 years; 46.6% male), after adjustment for all 
      covariates, age was independently associated with LACI(Baseline) (R(2)=0.10, 
      slope=0.16) and DeltaLACI (R(2)=0.15, slope=0.008; both P<0.001). African Americans 
      had the highest LACI(Baseline) value (18.0+/-7.7%). Although there was no 
      difference in LACI(Baseline) between women and men (P=0.19), DeltaLACI was higher in 
      women (1.0+/-1.1 vs 0.8+/-1.1%/year; P<0.001). Diabetes and higher body mass index 
      (BMI) were independently associated with LACI(Baseline) (both P<0.001). 
      LACI(Baseline) was independently associated with LV myocardial fibrosis markers 
      (native T1: R(2)=0.11, slope=0.09 [P=0.038]; extracellular volume: R(2)=0.08, 
      slope=0.28 [P=0.035]) and N-terminal prohormone of B-type natriuretic peptide 
      (NT-proBNP) concentration (R(2)=0.10, slope=-1.11; P<0.001), but was not 
      associated with interleukin 6 or high-sensitivity C-reactive protein. 
      CONCLUSIONS: Age, sex, ethnicity, diabetes and BMI were independent determinants 
      of LACI. LACI was independently associated with myocardial fibrosis markers and 
      NT-proBNP concentration.
CI  - Copyright (c) 2022 Elsevier Masson SAS. All rights reserved.
FAU - Pezel, Theo
AU  - Pezel T
AD  - Division of Cardiology, Johns Hopkins Hospital, School of Medicine, Johns Hopkins 
      University, 600 North Wolfe Street, Baltimore, MD 21287, USA; Department of 
      Cardiology, Lariboisiere Hospital, AP-HP, INSERM UMRS 942, University of Paris, 
      75010 Paris, France.
FAU - Venkatesh, Bharath Ambale
AU  - Venkatesh BA
AD  - Division of Cardiology, Johns Hopkins Hospital, School of Medicine, Johns Hopkins 
      University, 600 North Wolfe Street, Baltimore, MD 21287, USA.
FAU - Vasconcellos, Henrique Doria De
AU  - Vasconcellos HD
AD  - Division of Cardiology, Johns Hopkins Hospital, School of Medicine, Johns Hopkins 
      University, 600 North Wolfe Street, Baltimore, MD 21287, USA.
FAU - Kato, Yoko
AU  - Kato Y
AD  - Division of Cardiology, Johns Hopkins Hospital, School of Medicine, Johns Hopkins 
      University, 600 North Wolfe Street, Baltimore, MD 21287, USA.
FAU - Post, Wendy S
AU  - Post WS
AD  - Division of Cardiology, Johns Hopkins Hospital, School of Medicine, Johns Hopkins 
      University, 600 North Wolfe Street, Baltimore, MD 21287, USA.
FAU - Wu, Colin O
AU  - Wu CO
AD  - Division of Intramural Research, National Heart, Lung, and Blood Institute, 
      Bethesda, MD 20892, USA.
FAU - Heckbert, Susan R
AU  - Heckbert SR
AD  - Department of Epidemiology, University of Washington, Seattle, WA 98195, USA.
FAU - Bluemke, David A
AU  - Bluemke DA
AD  - University of Wisconsin School of Medicine and Public Health, Madison, WI 53726, 
      USA.
FAU - Cohen-Solal, Alain
AU  - Cohen-Solal A
AD  - Department of Cardiology, Lariboisiere Hospital, AP-HP, INSERM UMRS 942, 
      University of Paris, 75010 Paris, France.
FAU - Logeart, Damien
AU  - Logeart D
AD  - Department of Cardiology, Lariboisiere Hospital, AP-HP, INSERM UMRS 942, 
      University of Paris, 75010 Paris, France.
FAU - Henry, Patrick
AU  - Henry P
AD  - Department of Cardiology, Lariboisiere Hospital, AP-HP, INSERM UMRS 942, 
      University of Paris, 75010 Paris, France.
FAU - Lima, Joao A C
AU  - Lima JAC
AD  - Division of Cardiology, Johns Hopkins Hospital, School of Medicine, Johns Hopkins 
      University, 600 North Wolfe Street, Baltimore, MD 21287, USA. Electronic address: 
      jlima@jhmi.edu.
LA  - eng
PT  - Journal Article
DEP - 20220716
PL  - Netherlands
TA  - Arch Cardiovasc Dis
JT  - Archives of cardiovascular diseases
JID - 101465655
RN  - 0 (Biomarkers)
SB  - IM
MH  - Aged
MH  - *Atherosclerosis
MH  - Biomarkers
MH  - *Diabetes Mellitus
MH  - Ethnicity
MH  - Female
MH  - Fibrosis
MH  - Heart Ventricles
MH  - Humans
MH  - Male
MH  - Middle Aged
OTO - NOTNLM
OT  - Cardiac magnetic resonance
OT  - Couplage
OT  - Coupling
OT  - Imagerie par resonance magnetique cardiaque
OT  - Left atrium
OT  - Left ventricle
OT  - Multi-Ethnic Study of Atherosclerosis (MESA)
OT  - Oreillette gauche
OT  - Ventricule gauche
OT  - Etude Multi-Ethnique de l'Atherosclerose (MESA)
EDAT- 2022/07/30 06:00
MHDA- 2022/09/08 06:00
CRDT- 2022/07/29 22:05
PHST- 2021/12/31 00:00 [received]
PHST- 2022/04/11 00:00 [revised]
PHST- 2022/04/11 00:00 [accepted]
PHST- 2022/07/30 06:00 [pubmed]
PHST- 2022/09/08 06:00 [medline]
PHST- 2022/07/29 22:05 [entrez]
AID - S1875-2136(22)00134-6 [pii]
AID - 10.1016/j.acvd.2022.04.011 [doi]
PST - ppublish
SO  - Arch Cardiovasc Dis. 2022 Aug-Sep;115(8-9):414-425. doi: 
      10.1016/j.acvd.2022.04.011. Epub 2022 Jul 16.